DRSC/TRiP Functional Genomics Resources

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Protein Alignment PMP34 and SLC25A17

DIOPT Version :9

Sequence 1:NP_001246615.1 Gene:PMP34 / 38532 FlyBaseID:FBgn0052250 Length:314 Species:Drosophila melanogaster
Sequence 2:NP_006349.1 Gene:SLC25A17 / 10478 HGNCID:10987 Length:307 Species:Homo sapiens


Alignment Length:320 Identity:155/320 - (48%)
Similarity:208/320 - (65%) Gaps:30/320 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LSQVLSYQNFVHAVSGAAGGCIAMSTFYPLDTVRSRLQLEEAGDVRSTRQVIKEIVLGEGFQSLY 71
            ::.||||::.||||:||.|...||:.|:||||.|.|||::|....::|..|:.||:..||..:.|
Human     1 MASVLSYESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPY 65

  Fly    72 RGLGPVLQSLCISNFVYFYTFHALKAVASGGSPSQHSAL-KDLLLGSIAGIINVLTTTPFWVVNT 135
            ||..||:.|||.|||||||||::|||:...|   |||.. |||::|.:||::|||.|||.|||||
Human    66 RGWFPVISSLCCSNFVYFYTFNSLKALWVKG---QHSTTGKDLVVGFVAGVVNVLLTTPLWVVNT 127

  Fly   136 RLRMRNVA-GTSDEVNKHYKNLLEGLKYVAEKEGIAGLWSGTIPSLMLVSNPALQFMMYEMLKRN 199
            ||:::... ...|.|..:||.:::....:...|||:.||:||.|||:||.|||:|||.||.|||.
Human   128 RLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPAIQFMFYEGLKRQ 192

  Fly   200 IMRFTGGEMGSLSFFFIGAIAKAFATVLTYPLQLVQT---KQRHRSKESDSKPSTSAGSTPRTES 261
            ::: ...::.||..|.|||:|||.||.:|||||.||:   ..|||....:           ||..
Human   193 LLK-KRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPEN-----------RTLG 245

  Fly   262 TLELMISILQHQ-----GIRGLFRGLEAKILQTVLTAALMFMAYEKIAG---TVGMLLKR 313
            :|..::.:| ||     ||.||::|||||:|||||||||||:.|||:..   || |.|||
Human   246 SLRNILYLL-HQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAATFTV-MGLKR 303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PMP34NP_001246615.1 Mito_carr 15..96 CDD:278578 42/80 (53%)
Mito_carr 105..202 CDD:278578 49/98 (50%)
Mito_carr 214..303 CDD:278578 47/96 (49%)
SLC25A17NP_006349.1 Necessary for targeting to peroxisomes and interaction with PEX19 1..147 74/148 (50%)
Mito_carr 10..95 CDD:278578 45/84 (54%)
Mito_carr 97..197 CDD:278578 49/100 (49%)
Solcar 2 99..192 46/92 (50%)
Peroxisome localization signal 190..199 2/9 (22%)
Mito_carr 199..291 CDD:278578 49/103 (48%)
Solcar 3 200..294 50/105 (48%)
Necessary for targeting to peroxisomes and interaction with PEX19 244..307 33/62 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 101 1.000 Domainoid score I6993
eggNOG 1 0.900 - - E1_COG4266
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4637
Inparanoid 1 1.050 263 1.000 Inparanoid score I3093
Isobase 1 0.950 - 0 Normalized mean entropy S2275
OMA 1 1.010 - - QHG53601
OrthoDB 1 1.010 - - D1186395at2759
OrthoFinder 1 1.000 - - FOG0007252
OrthoInspector 1 1.000 - - oto91447
orthoMCL 1 0.900 - - OOG6_103707
Panther 1 1.100 - - LDO PTHR45939
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5749
SonicParanoid 1 1.000 - - X6128
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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