DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dyl and COL21A1

DIOPT Version :9

Sequence 1:	NP_647890.2	Gene:	dyl / 38531	FlyBaseID:	FBgn0066365	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001305680.1	Gene:	COL21A1 / 81578	HGNCID:	17025	Length:	957	Species:	Homo sapiens

Alignment Length:	192	Identity:	46/192 - (23%)
Similarity:	65/192 - (33%)	Gaps:	61/192 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 PGLPG-----GEYGLPQIGAN----GLSEEYGPPEAYERNDFALGGPGVLPPAAYP-DPRHPASD 399
            ||.||     ||.|:|....|    |...|.||| ..:....|.|.||::.....| .|..|.|.
Human   592 PGAPGQDGTRGEPGIPGFPGNRGLMGQKGEIGPP-GQQGKKGAPGMPGLMGSNGSPGQPGTPGSK 655

  Fly   400 ATGAYSENQPDVVPSPQAQTSAAVPTADSGTVSGPASSQSP-QPQPTGSNELGLP---------- 453
            .    |:.:|.:...|.|          ||....|.::.|| :|     ..:|||
Human   656 G----SKGEPGIQGMPGA----------SGLKGEPGATGSPGEP-----GYMGLPGIQGKKGDKG 701

  Fly   454 ---------------PPPLPGQ---SGQYSTVKRKDDLSAGGNLVSLGGRPRSVEGLDDLRG 497
                           ...:|||   .|.:.....:.:....|...::|.:..|  |:|.|.|
Human   702 NQGEKGIQGQKGENGRQGIPGQQGIQGHHGAKGERGEKGEPGVRGAIGSKGES--GVDGLMG 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dyl	NP_647890.2	ZP	90..345	CDD:214579	46/192 (24%)
dyl	NP_647890.2	PHA03378	<339..494	CDD:223065	43/187 (23%)
COL21A1	NP_001305680.1	vWFA	34..254	CDD:320736
		LamG	230..412	CDD:328935
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..786		46/192 (24%)
		Glutenin_hmw	<454..>764	CDD:281191	46/192 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	825..938
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910