DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dyl and MATN2

DIOPT Version :9

Sequence 1:	NP_647890.2	Gene:	dyl / 38531	FlyBaseID:	FBgn0066365	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_002371.3	Gene:	MATN2 / 4147	HGNCID:	6908	Length:	956	Species:	Homo sapiens

Alignment Length:	182	Identity:	38/182 - (20%)
Similarity:	59/182 - (32%)	Gaps:	59/182 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VLNTQHLSVHGDASHIESAALPLEHRAGYGPPAPIYGAPQGPLSTGATNDV------------SE 70
            |.|...|......|.:|.|...:.|                 ||||....:            :|
Human   105 VKNEFSLKTFKRKSEVERAVKRMRH-----------------LSTGTMTGLAIQYALNIAFSEAE 152

  Fly    71 EAWPLAS---------TNDSPQ--IKHLQVQCEKTHMRV------NIEFDRPFYGMIFSKGFYSD 118
            .|.||..         |:..||  :..:..:...|.:.:      .::|:.       .|...|:
Human   153 GARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNT-------LKSIGSE 210

  Fly   119 PHCVHLKPGTGH-----LSATFEIFLNSCGMTSSANHNAAGYGAPTPSGSYV 165
            ||..|:......     |::.|:..|.:..|.|:..||.|.:....| ||||
Human   211 PHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIP-GSYV 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dyl	NP_647890.2	ZP	90..345	CDD:214579	20/87 (23%)
dyl	NP_647890.2	PHA03378	<339..494	CDD:223065
MATN2	NP_002371.3	vWA_Matrilin	54..276	CDD:238752	38/182 (21%)
		FXa_inhibition	283..318	CDD:291342
		FXa_inhibition	324..359	CDD:291342
		FXa_inhibition	365..400	CDD:291342
		FXa_inhibition	406..441	CDD:291342
		vWFA	<438..481	CDD:294047
		FXa_inhibition	488..523	CDD:291342
		vWFA	<520..563	CDD:294047
		vWFA	<561..603	CDD:294047
		vWFA	<602..644	CDD:294047
		vWA_Matrilin	652..892	CDD:238752
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..863
		Matrilin_ccoil	911..953	CDD:287378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910