DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dyl and dy

DIOPT Version :9

Sequence 1:NP_647890.2 Gene:dyl / 38531 FlyBaseID:FBgn0066365 Length:611 Species:Drosophila melanogaster
Sequence 2:NP_511130.2 Gene:dy / 32130 FlyBaseID:FBgn0004511 Length:699 Species:Drosophila melanogaster


Alignment Length:646 Identity:258/646 - (39%)
Similarity:321/646 - (49%) Gaps:205/646 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 LPLEHRAGYGPPAP----IYGAPQGP--------------------------------------- 59
            :||.....:|||.|    .|..|..|                                       
  Fly   159 IPLSFGQPFGPPPPPGAQFYKGPPPPQLQQRPQPPPQLQLQVQPQQQQQQQQQHTQQQGQQQQVQ 223

  Fly    60 ---LSTGATNDVSEEAWPLASTNDSPQIKHLQVQCEKTHMRVNIEFDRPFYGMIFSKGFYSDPHC 121
               ||.|.::  :.|.| .|...|.|:|..|.|:|||..|:|.::||:||.|::||||.||:.:|
  Fly   224 VPDLSVGGSS--NNEIW-AAPVQDMPKIVSLDVKCEKNGMKVFVQFDKPFNGIVFSKGHYSNMNC 285

  Fly   122 VHLKPGTGHLSATFEIFLNSCGMTSSANHNAAGYG---APTPSGSYVENTIIIQYDPYVQEVWDQ 183
            |||..|.|..||:|:|.|:.||...:.::...|||   ..|.:|:|.||.|:|||||.|||||||
  Fly   286 VHLPSGLGRSSASFDIGLHECGTAGNTDNYGQGYGHEAGSTGAGTYFENIIVIQYDPQVQEVWDQ 350

  Fly   184 ARKLRCTWYDFYEKAVTFRPFQVDMLHAVTANFLGDNLQCWMQIQVGKGPWASEVSGIVKIGQTM 248
            ||||||||:|.|||:||||||.||||..|.|:|.|||:.||||||||||||||||||:|||||||
  Fly   351 ARKLRCTWHDQYEKSVTFRPFPVDMLDVVRADFAGDNVGCWMQIQVGKGPWASEVSGLVKIGQTM 415

  Fly   249 TMVLAIKDDENKFDMLVRNCVAHDGKRAPIQLVDQNGCVVRPKIMSKFQKIKNFGPSASVVSFAY 313
            |||||||||::||||||||||||||||||||||||.|||.|||:||:|.||||||.||||:|:|:
  Fly   416 TMVLAIKDDDSKFDMLVRNCVAHDGKRAPIQLVDQRGCVTRPKLMSRFTKIKNFGASASVLSYAH 480

  Fly   314 FQAFKFPDSMNVHFQCVIQVCRYNCPEPKCGPGLPGGEYGLP-----QIGANGLSEEYGPPEAYE 373
            ||||||||||.|||||.||:|||:||| :|     ..|..|.     |:|.   ..:|||     
  Fly   481 FQAFKFPDSMEVHFQCTIQICRYHCPE-QC-----SAETNLQDVHHLQVGP---ESQYGP----- 531

  Fly   374 RNDFALGGPGVLPPAAYPDPRHPASDATGAYSENQPDVVPSPQAQTSAAVPTADSGTVSGPASSQ 438
                        ||..:.|..|.|| |.|                                    
  Fly   532 ------------PPQLHVDAYHVAS-AIG------------------------------------ 547

  Fly   439 SPQPQPTGSNELGLPPPPLPGQSGQYSTVKRKDDLSAGGNLVSLGGRPRSVEGLDDLRGVRRRRD 503
                                         ||:|:                       |.|:||..
  Fly   548 -----------------------------KRRDE-----------------------RRVQRRAR 560

  Fly   504 TMDIVVKPQRIYKRNAQEMTDVNTSRIIQVVAPGDVNFALNSNASNETVVIQSARSA-------- 560
            .   |.:||            |..:|||:||:.||:.||::..|.........|.|.        
  Fly   561 A---VAEPQ------------VGLNRIIKVVSSGDLTFAIDDQAGGNGSSTNGANSGVDRSPQTM 610

  Fly   561 -----DAETICMSVPSFVGGLVMLLLVLAVASLVAAFLFVRVRHF-----DRKGAGMAYVN 611
                 :...|||:.|.|...|::||.:|..:.|.:|.|:||:|.|     ..|...:|:.|
  Fly   611 VFPLREEGLICMTTPGFAITLIVLLGILVTSCLTSAVLYVRLRPFSSFAGSAKERAVAFTN 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dylNP_647890.2 ZP 90..345 CDD:214579 181/257 (70%)
PHA03378 <339..494 CDD:223065 21/159 (13%)
dyNP_511130.2 ZP 254..513 CDD:214579 181/264 (69%)
Zona_pellucida <403..510 CDD:278526 90/112 (80%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45473234
Domainoid 1 1.000 82 1.000 Domainoid score I5383
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D245041at33208
OrthoFinder 1 1.000 - - FOG0005923
OrthoInspector 1 1.000 - - otm14807
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR46560
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X161
87.950

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