DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dyl and cutl-12

DIOPT Version :9

Sequence 1:	NP_647890.2	Gene:	dyl / 38531	FlyBaseID:	FBgn0066365	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001309578.1	Gene:	cutl-12 / 188735	WormBaseID:	WBGene00011928	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	582	Identity:	120/582 - (20%)
Similarity:	205/582 - (35%)	Gaps:	130/582 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 QVQCEKTHMRVNIEFDRPFYGMIFSKGFYSDPHCVHLKPGTGHLSATFEI---FLNSCGMTSSAN 149
            :::|....:|::|.....|.|.::.:||:....| ||...|...:....:   |...|.:....|
Worm    35 KLECGSEGIRLHINPTGTFGGHVYVRGFFPQTVC-HLNYCTRLTNRPIVMDLPFRGPCNVRRRRN 98

  Fly   150 HNAAGYGAPTPSGSYVENTIIIQYDPYVQEVWDQARKLRCTWYDFYEKAVTFRPFQVDMLHAVTA 214
                  .|| ||.|| :.|:|||:.|.....:|:|.:|.|    .|.:..:....::::....:.
Worm    99 ------VAP-PSISY-DVTVIIQHHPLFVTSFDKAYRLNC----IYRQQESTLQQRINVSDIPST 151

  Fly   215 NFLGDNL-QCWMQIQVG--KGPWASEVSGIVKIGQTMTMVLAIKDDENKFDMLVRNCVAHDGKRA 276
            .....|. :|...:..|  .||    |.....:|.  .:|.....|.::|..:|.:||..|....
Worm   152 ALQSKNAPKCRYDVLSGSLNGP----VVRFANVGD--VVVHKWTCDSDRFGFVVHSCVVRDESGK 210

  Fly   277 PIQLVDQNGCVVRPKIMSKFQKIKNFGPSASVVSFAYFQAFKFPDSMNVHFQCVIQVCRYNCPEP 341
            ..|.:|:.|||..   .|.|.::.......|  :|...:||::.|.:.|||.|.|..|:..
Worm   211 DFQFIDERGCVTD---FSLFPEVSYSDDLKS--AFTAVRAFRYADQVMVHFSCQITTCQKQ---- 266

  Fly   342 KCGPGLPGGEYGLPQIGANGLSE------EYGPPEA----YERNDFAL---GGPGVLPP------ 387
                          :.|..|:|.      :.||.:.    :|:|....   ||...|||
Worm   267 --------------ENGCEGISPPICRPMDLGPIKVHYVKHEKNGEKFDEGGGVETLPPRTENTS 317

  Fly   388 ----------------AAYPDPRHPASDA------TGAYSENQPDVVPSPQAQTSAAVPTADSGT 430
                            .|:....|..:.:      |....|:.....||.:.:.....|..:||.
Worm   318 EGSTTTVRSTTTRERAQAFSTTTHKTTTSSSLQLKTVQRDEDNNSFSPSSKFRNGYNFPNVESGE 382

  Fly   431 VSGPASSQSPQPQPTGSNELGLPPPPLPGQSGQYSTVKRKDDLSAGGNLVSLGGRPRSVEGLDDL 495
            ..|..::.          |.|:..........:|.....||:..|..|.:||...|..:...:..
Worm   383 GVGQDNTA----------EFGVKRKSSDAGVNEYGIEIAKDESQAKQNKISLVAEPEKLPKREVF 437

  Fly   496 RGVRRRRDTMDIVVKP--------------QRIYKR---NAQEMTDVNTSRIIQVVAPGDVNFAL 543
            . |.....|||..::|              .|.:||   :|....:|.|::|:          .|
Worm   438 H-VETISKTMDSELEPLPYPTKASVYQHRSPRSHKRVLEDANITLEVETTKIM----------IL 491

  Fly   544 NSNASNETVVIQSAR--SADAETICMSVPSFVGGLVMLLLVLAVASLVAAFLFVRVRHFDRK 603
            .:..|.|...:..||  |......|.:..::|.. .:||..|.|..:::....:..|.:.:|
Worm   492 ENEPSAEKFRLGEAREQSGPEPMKCTTSENYVSN-TLLLTTLGVLQVISILALITQRFYYKK 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dyl	NP_647890.2	ZP	90..345	CDD:214579	62/260 (24%)
dyl	NP_647890.2	PHA03378	<339..494	CDD:223065	32/195 (16%)
cutl-12	NP_001309578.1	ZP	37..281	CDD:214579	65/285 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107918
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810