DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dyl and AgaP_AGAP007100

DIOPT Version :9

Sequence 1:	NP_647890.2	Gene:	dyl / 38531	FlyBaseID:	FBgn0066365	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_308658.4	Gene:	AgaP_AGAP007100 / 1270003	VectorBaseID:	AGAP007100	Length:	1504	Species:	Anopheles gambiae

Alignment Length:	540	Identity:	107/540 - (19%)
Similarity:	178/540 - (32%)	Gaps:	162/540 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 CEKTHMRVNIEFDRPFYGMIFSKGFYSDPHCVHLKPGTGHLSATFEIFLNSCGMTSSANHNAAGY 155
            |.:..|...:.....|.|.|::.|||.  .|                |....|.|.:....:...
Mosquito   981 CNEDGMEFTLRTPEGFVGRIYAYGFYD--RC----------------FFRGNGGTVNVLRISGPQ 1027

  Fly   156 GAPTPS----GSYVENTIIIQYDPYVQEVWDQARKLRCTWYDFYEKAVTF--------RPFQVDM 208
            |.|...    |..:.|.|::|:...||...|:...|.|.:....|..||.        .|..::.
Mosquito  1028 GYPECGTQRYGDTMTNIIVVQFSDNVQTGRDKRFNLTCMFRGPGEAVVTSGYIGAGSGSPIPIEY 1092

  Fly   209 LHAVTANFLGDNLQCWMQIQVGKGPWASEVSGIVKIGQTMTMVLAIKDD-ENKFDMLVRNCVAHD 272
            |.|  .|.:.:.::..:..|       ...:..:.:|..:|..|..:|. .:..|:...|.||.|
Mosquito  1093 LPA--ENSMSNKVRLMILYQ-------GRPTTTIAVGDPLTFRLESQDGYSHATDIFATNVVARD 1148

  Fly   273 ---GKRAPIQLVDQNGCVVRPKIMSKFQKIKNFGPSASVVSFAYFQAFKFPDSMNVHFQCVIQVC 334
               |:  .:||:|..||.|...:..:..:.::     :....|.|.|||.|:|..:.|:..::.|
Mosquito  1149 PYSGR--SVQLIDNYGCPVDSLVFPELGRSRD-----NDALEARFNAFKIPESNFLVFEATVRTC 1206

  Fly   335 RYNCPEPKCGPGLPGGEYGLPQIGANGLSEEYGPPEAYERNDFALGGPGVLPP--AAYPDPRHPA 397
            |..|....| || |.|. ..|..|....|.|.|....           |...|  ||.|||....
Mosquito  1207 RGGCQPAYC-PG-PSGR-SEPSFGRRKRSLENGTETI-----------GTAEPLVAANPDPVDDE 1257

  Fly   398 SDATGAYSENQPDVVPSPQAQTSAAVPTADSGTVSGPASSQSPQPQPTGSNELGLPPPPLPGQSG 462
            .|.....:....:     :..|||....|...|::..|.:.||...|....|:
Mosquito  1258 DDEVSIVNGTMVN-----ENATSAKTRDASGDTITAEADTTSPTEMPEQVREM------------ 1305

  Fly   463 QYSTVKRKDDLSAGGNLVSLGGRPRSVEGLDDLRGVRRRRDTMDIVVKPQRIYKRNAQEMTDVNT 527
                                               :..|      ..:|.::: ::.:||.....
Mosquito  1306 -----------------------------------IESR------YFRPLQVF-QSREEMQQDTV 1328

  Fly   528 SRIIQVVAPGDVNFALNSNASNETVVIQSARSADAETICMSVPSFVG--GLVMLLLVLAVASLVA 590
            :|  ::|||                         .|::|::...:.|  ..|:||::|.::...|
Mosquito  1329 AR--KMVAP-------------------------IESVCLTHAEYYGLISAVILLIILLISITFA 1366

  Fly   591 AFL--------FVRVRHFDR 602
            |.:        |::.|..||
Mosquito  1367 AGIVYRSYWKVFIKNRTLDR 1386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dyl	NP_647890.2	ZP	90..345	CDD:214579	59/269 (22%)
dyl	NP_647890.2	PHA03378	<339..494	CDD:223065	28/156 (18%)
AgaP_AGAP007100	XP_308658.4	PAN_AP_HGF	153..234	CDD:238532
		PAN_AP_HGF	247..>306	CDD:238532
		PAN_AP_HGF	352..427	CDD:238532
		PROL5-SMR	<626..703	CDD:292254
		PAN_AP_HGF	878..964	CDD:238532
		ZP	981..1219	CDD:214579	61/273 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910