Protein Alignment KRT6A and krt5

DIOPT Version :9

• Sequence 1: NP_005545.1
• Gene: KRT6A / 3853
• HGNCID: 6443
• Length: 564
• Species: Homo sapiens
• Sequence 2: NP_571231.2
• Gene: krt5 / 797351
• ZFINID: ZDB-GENE-991110-23
• Length: 566
• Species: Danio rerio
• Alignment Length: 593
• Identity: 348/593 - (58%)
• Similarity: 426/593 - (71%)
• Gaps: 63/593 - (10%)

Human     5 STTIRSHSSS---------------RRGFSA-NSARLPGVSRSGFSSVSVSRSRGSGGLGGACGG 53
            ||:.::.:||               |:.||: :::.:|..||   ||||..||.|.|      ||
Zfish     2 STSFKTFTSSGSMSGGMGGGMGGGIRKNFSSMSTSAVPMGSR---SSVSFRRSGGGG------GG 57

Human    54 AGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGSYGFGGA-GSGFGFGGGAGIGFG--LGGG 115
            .|||:    |.|||...|:|||    .||.||..||.:|.||. |||.|||||||.|.|  .|||
Zfish    58 GGFGA----GSGGSFSYSMGGG----GGGGGSGFGGGFGSGGGFGSGGGFGGGAGFGGGSAYGGG 114

Human   116 AGLAGGFGGPGFPVCPPGG---IQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASF 177
            ||..||||        |||   |..|||||:||.||||:|||.||.||.:|:||||||||:||||
Zfish   115 AGFGGGFG--------PGGVVPITAVTVNQNLLAPLNLEIDPNIQVVRTQEKEQIKTLNNRFASF 171

Human   178 IDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGM 242
            ||||||||||||||||||:|||||  .|.|.|::.:||.||.|||||||.:..|:.:|:.||:.|
Zfish   172 IDKVRFLEQQNKVLETKWSLLQEQ--TTTRSNIDAMFEAYIANLRRQLDGLGNEKMKLEGELKNM 234

Human   243 QDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELS 307
            |:||||||||||||||||.|.|||||.|||||||||||||||:||.|:|.||||||||:::.||.
Zfish   235 QNLVEDFKNKYEDEINKRAAVENEFVLLKKDVDAAYMNKVELEAKVDSLQDEINFLRAIFEEELR 299

Human   308 QMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGD 372
            ::|:.|.|||||:.|||:||||:|:|:|||:||||:||.||||||||||:.|:||:|.:||::||
Zfish   300 ELQSQIKDTSVVVEMDNSRNLDMDAIVAEVRAQYEDIANRSRAEAESWYKQKFEEMQSSAGKYGD 364

Human   373 DLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKA 437
            ||||||.|||::||||.||::||:.||.|.|||:|.||:||:|||:|:||||.:::.||||||:|
Zfish   365 DLRNTKAEIADLNRMISRLQNEIEAVKGQRANLEAQIAEAEERGELAVKDAKLRIKDLEDALQRA 429

Human   438 KQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSS------- 495
            |||:||.::|||||||||||||:|||||||||||||.|: ..|.....|.:.:|:.||
Zfish   430 KQDMARQVREYQELMNVKLALDIEIATYRKLLEGEESRI-ASGGNTATIHIQESSSSSGGGGGGF 493

Human   496 GYGGASGVGSGLGLGGGSSYSYGSGLGVGGGF--SSSSGRAIGG--GLSSVGGGSSTIKYTTTS- 555
            ||||.||.|.|.|.||||.|..|||.|.|.||  ...||.:|||  |:|..|||...|..:.:|
Zfish   494 GYGGGSGYGGGSGFGGGSGYGGGSGFGGGSGFGYGGGSGMSIGGGSGMSMSGGGGGQISMSRSSI 558

Human   556 -SSSRKSY 562
             ||.::.:
Zfish   559 VSSQKRRF 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT6A	NP_005545.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		7/33 (21%)
		Head	2..162		83/178 (47%)
		Keratin_2_head	<59..159	CDD:318448	58/105 (55%)
		Filament	162..475	CDD:306535	224/312 (72%)
		Coil 1A	163..198		31/34 (91%)
		Linker 1	199..217		8/17 (47%)
		Coil 1B	218..309		65/90 (72%)
		Linker 12	310..333		15/22 (68%)
		Coil 2	334..472		98/137 (72%)
		Tail	473..564		42/103 (41%)
krt5	NP_571231.2	Keratin_2_head	<129..153	CDD:292825	17/23 (74%)
		Filament	156..467	CDD:278467	224/312 (72%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I21828
eggNOG	1	0.900	-	-		E1_28N6C
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	622	1.000	Inparanoid score	I5034
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X62
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.960