DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hexo1 and hexb

DIOPT Version :9

Sequence 1:	NP_523924.1	Gene:	Hexo1 / 38528	FlyBaseID:	FBgn0041630	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_009299722.1	Gene:	hexb / 323613	ZFINID:	ZDB-GENE-030131-2333	Length:	544	Species:	Danio rerio

Alignment Length:	524	Identity:	166/524 - (31%)
Similarity:	256/524 - (48%)	Gaps:	82/524 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 FIDFNFNGIARQQKLWRAVEDRFMNMLEAQIPDRKVLARGGYRMSVNINTPDEPTPARLTLDTDE 154
            :.::.|..:.||:|..:...|..::.|:                 |.|.:.|.......:|.|||
Zfish    82 YFEYMFGELKRQEKSRKKAFDSDLSELQ-----------------VWITSADPECDGYPSLRTDE 129

  Fly   155 SYTLDIDTDASGHVLANITASNFFGARHGLETLAQLIVYDDIR-REVQVTANATINDAPVYKWRG 218
            ||:|.:|..:     |.:.|:|.:||..||||.:||:..||.. |.:..|   .|:|.|.:..||
Zfish   130 SYSLSVDETS-----AVLKAANVWGALRGLETFSQLVYEDDYGVRNINKT---DISDFPRFAHRG 186

  Fly   219 LLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPEL--HKLGAYSQ-RQVY 280
            :|||:||::..:|.|...||.||:.|.|.|||||.|..|||...:..|||  .:.|||.. ..||
Zfish   187 ILLDSSRHFLPLKVILANLEAMAMNKFNVFHWHIVDDPSFPFMSRTFPELSQKRKGAYHPFTHVY 251

  Fly   281 TRRDVAEVVEYGRVRGIRVMPEFDAPAHVGEGWQH--KN-MTACFN-AQPWKSFCVEPPCGQLDP 341
            |..||..|:|:.|:|||||:.|||.|.|. :.|.:  |: :|.|:: :.|..||      |.::|
Zfish   252 TPSDVKMVIEFARMRGIRVVAEFDTPGHT-QSWGNGIKDLLTPCYSGSSPSGSF------GPVNP 309

  Fly   342 TVNEMYDVLEDIY---GTMFDQFNPDIF-HMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFMR 402
            .:|..|:.:..::   .|:|    ||.: |:|||||..|||.|:..||::|.:||:|   .|:.:
Zfish   310 ILNSSYEFMAQLFKEISTVF----PDAYIHLGGDEVDFSCWKSNPDIQKFMNQQGFG---TDYSK 367

  Fly   403 LWGHFQTEALGRVDKVANGTHTPIILWTSGLTEEPFIDEYLNPERYIIQIW--TTGVDPKVKKIL 465
            |...:    :.|:..:...|....::|     :|.|.:.........|.:|  ......::.|:.
Zfish   368 LESFY----IQRLLDIVAATKKGYMVW-----QEVFDNGVKLKADTQIHVWKGRPQYQDEMAKVT 423

  Fly   466 ERGYKIIVSNYDALYLDCGGAGWVTDGNNWCSPYIGWQKVYDNSLKSIAGD--YEHHVLGAEGAI 528
            ..|:..::|.  ..||:     .|:.|.:|..       :|....::..|.  .:..|:|.|..:
Zfish   424 AAGFSALLST--PWYLN-----RVSYGQDWVD-------IYKADPQNFNGTDAQKKLVIGGEACL 474

  Fly   529 WSEQIDEHTLDNRFWPRASALAERLWSNPA-EGWRQAESRLLLHRQRLVDNGLGAEAMQPQWCLQ 592
            |.|.:|...|..|.||||||:||||||:.: .....|.:||..||.|:|..|:.||.:....|
Zfish   475 WGEYVDATNLTPRLWPRASAVAERLWSDASVTDVGNAYTRLAQHRCRMVRRGIPAEPLFVGHC-- 537

  Fly   593 NEHE 596
             .||
Zfish   538 -RHE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hexo1	NP_523924.1	Glycohydro_20b2	69..190	CDD:291511	26/99 (26%)
Hexo1	NP_523924.1	GH20_HexA_HexB-like	214..579	CDD:119332	125/380 (33%)
hexb	XP_009299722.1	Glycohydro_20b2	37..160	CDD:291511	26/99 (26%)
hexb	XP_009299722.1	GH20_HexA_HexB-like	182..526	CDD:119332	125/380 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580453
Domainoid	1	1.000	191	1.000	Domainoid score	I3177
eggNOG	1	0.900	-	-		E1_COG3525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3531
OMA	1	1.010	-	-		QHG54329
OrthoDB	1	1.010	-	-		D164123at33208
OrthoFinder	1	1.000	-	-		FOG0001678
OrthoInspector	1	1.000	-	-		mtm6615
orthoMCL	1	0.900	-	-		OOG6_100456
Panther	1	1.100	-	-	O	PTHR22600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2560
SonicParanoid	1	1.000	-	-		X846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.840