DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hexo1 and Hexo2

DIOPT Version :9

Sequence 1:	NP_523924.1	Gene:	Hexo1 / 38528	FlyBaseID:	FBgn0041630	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_525081.1	Gene:	Hexo2 / 31808	FlyBaseID:	FBgn0041629	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	636	Identity:	231/636 - (36%)
Similarity:	339/636 - (53%)	Gaps:	72/636 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TALGVALLLALVS---QLAAHSSDDL----VYGYECRSGYCQKVEL--SEENYVKAI-------- 53
            :|:|..|||:|:|   ..|...:||:    ..|...|...|.:.::  :|...|..:
  Fly    14 SAVGSLLLLSLLSFAVGAALTRADDVGSDADAGSASRKWLCSRTDICTAEGEMVAGLQYAPEIFE 78

  Fly    54 SLPVCRLFCGSSIGTLWPKPTGTVRLDTLMRQVDISFIDFNFN-----------GIARQQKLWRA 107
            |...|||.|| ..|.:||.|||        ::..||.....|:           |.|..|.| |.
  Fly    79 SQRDCRLSCG-KYGAIWPMPTG--------KECTISHRRVRFDPWKVRFHVVAPGEAATQFL-RE 133

  Fly   108 VEDRFM-NMLEAQIPDRKVLARGGYRMSVNINTPDEPTPARLTLD--TDESYTLDIDTDASGHVL 169
            ....|: |:|:..|  |........::.|.....:|    .|.||  |||||.|.:.|..:. ..
  Fly   134 TNRLFVSNLLKECI--RNCTLETSKQILVRSTVANE----SLVLDWPTDESYALVVRTTETA-TF 191

  Fly   170 ANITASNFFGARHGLETLAQLIVYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIK 234
            .:|.|:..:||||..|||:.|:. ..:...:.:...|.|.|.|.:..||:||||:||:..:|.|:
  Fly   192 VDIQATTVYGARHAFETLSNLVT-GSLSNGLLMVTTANITDRPAFSHRGVLLDTARNFVPLKFIR 255

  Fly   235 RTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQRQVYTRRDVAEVVEYGRVRGIRV 299
            .||:.||..|||..|||:.|:||||||:.:.||:.:.||||..|.|:|:|...:|:|.|:||||:
  Fly   256 STLDAMAASKLNVLHWHVVDTHSFPLEITRVPEMQRYGAYSSSQTYSRQDALNLVKYARLRGIRI 320

  Fly   300 MPEFDAPAHVGEGWQH------KNMTACFNAQPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMF 358
            :.|.|.|:|.|.|||.      .||:.|.|..||:.|||:||||||:|..:.||.||::|:..:.
  Fly   321 LIEIDGPSHAGNGWQWGPAAGLGNMSVCLNQSPWRRFCVQPPCGQLNPLNDHMYAVLKEIFEDVA 385

  Fly   359 DQFNP-DIFHMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVAN-- 420
            :...| :..|||||||...|||::..|:..|:.:|:.|....|:|||..|....|...|::..
  Fly   386 EVGAPEETLHMGGDEVFLPCWNNTDEIRDGMRARGYDLSEQSFLRLWSQFHQRNLNAWDEINERM 450

  Fly   421 --GTHTP--IILWTSGLTEEPFIDEYLNPERYIIQIWTTGVDPKVKKILERGYKIIVSNYDALYL 481
              |...|  :|:|:|.||...:|:.||..||:|||.|....|...:::|:|||::|||..:|.||
  Fly   451 YPGIKEPKSVIIWSSHLTNPRYIETYLPKERFIIQTWVESQDALNRELLQRGYRLIVSTKNAWYL 515

  Fly   482 DCGGAGWVTDGNNWCSPYIGWQKVYDNSLKSIAGDYEHHVLGAEGAIWSEQIDEHTLDNRFWPRA 546
            |.|..|        .:.|..|:.||.:.:.  .|..:..|||.|..:|||.:|:::|::|.||||
  Fly   516 DHGFWG--------STSYYNWRTVYSSGMP--VGRSKDQVLGGEVCMWSEYVDQNSLESRIWPRA 570

  Fly   547 SALAERLWSNPAEGWRQAESRLLLHRQRLVDNGLGAEAMQPQWCLQNEHEC 597
            .|.|||:||||......|:.|...:|:||:..|:.|:|:.|.||:.:|.:|
  Fly   571 GAAAERMWSNPKSSALLAQRRFYRYRERLLARGIHADAVIPHWCVLHEGQC 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hexo1	NP_523924.1	Glycohydro_20b2	69..190	CDD:291511	39/134 (29%)
Hexo1	NP_523924.1	GH20_HexA_HexB-like	214..579	CDD:119332	157/377 (42%)
Hexo2	NP_525081.1	Glycohydro_20b2	93..212	CDD:291511	39/134 (29%)
Hexo2	NP_525081.1	GH20_HexA_HexB-like	235..603	CDD:119332	157/377 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448730
Domainoid	1	1.000	232	1.000	Domainoid score	I643
eggNOG	1	0.900	-	-		E1_COG3525
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I864
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54329
OrthoDB	1	1.010	-	-		D164123at33208
OrthoFinder	1	1.000	-	-		FOG0001678
OrthoInspector	1	1.000	-	-		mtm6615
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2560
SonicParanoid	1	1.000	-	-		X846
	12	11.940