Protein Alignment Hexo1 and HEXB

DIOPT Version :9

• Sequence 1: NP_523924.1
• Gene: Hexo1 / 38528
• FlyBaseID: FBgn0041630
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_000512.2
• Gene: HEXB / 3074
• HGNCID: 4879
• Length: 556
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 186/616 - (30%)
• Similarity: 278/616 - (45%)
• Gaps: 113/616 - (18%)

  Fly    10 VALLLALVSQLAAHSSDDLVYGYECRSGYCQKVELSEENYVKAISLPVCRLFCGSSIGTLWPKPT 74
            :|.:|||::|:|      ||         .|..|.:....|.|...|           .|||.|.
Human    23 LAAMLALLTQVA------LV---------VQVAEAARAPSVSAKPGP-----------ALWPLPL 61

  Fly    75 GTVRLDTLMRQVDISF-IDFNFNGIARQQKLWRAVEDRFMNM----------------LEAQIPD 122
            .......|:.....:| |..:.|..|...  ...:|:.|...                .:|:...
Human    62 LVKMTPNLLHLAPENFYISHSPNSTAGPS--CTLLEEAFRRYHGYIFGFYKWHHEPAEFQAKTQV 124

  Fly   123 RKVLARGGYRMSVNINTPDEPTPARLTLDTDESYTLDIDTDASGHVLANITASNFFGARHGLETL 187
            :::|      :|:.:.:..:..|   .:.:||||||.:.     ..:|.:.|:..:||..||||.
Human   125 QQLL------VSITLQSECDAFP---NISSDESYTLLVK-----EPVAVLKANRVWGALRGLETF 175

  Fly   188 AQLIVYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHI 252
            :|| ||.|......:. .:||.|:|.:..||:|:||||:|..||.|.:||:.||..|.|..||||
Human   176 SQL-VYQDSYGTFTIN-ESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHI 238

  Fly   253 TDSHSFPLEVKKRPELHKLGAYSQRQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHV---GEGWQ 314
            .|..|||.:....|||...|:||...|||..||..|:||.|:|||||:||||.|.|.   |:| |
Human   239 VDDQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKG-Q 302

  Fly   315 HKNMTACFNAQ-PWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFNPDIFHMGGDEVSTSCW 378
            ...:|.|::.| ...||      |.::||:|..|..|...:..:.:.|.....|:|||||...||
Human   303 KDLLTPCYSRQNKLDSF------GPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCW 361

  Fly   379 NSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVANGTHTPIILWTSGLTEEPFIDEYL 443
            .|:..||.:|:::|:|   .||.:|...:..:.|..:..:..|:    |:|     :|.|.|:..
Human   362 ESNPKIQDFMRQKGFG---TDFKKLESFYIQKVLDIIATINKGS----IVW-----QEVFDDKAK 414

  Fly   444 NPERYIIQIWTTGVDP-KVKKILERGYKIIVSNYDALYLDCGGAGWVTD----GNNWCSPYIGWQ 503
            .....|:::|.....| ::.::...|:.:|:|           |.|..|    |.:       |:
Human   415 LAPGTIVEVWKDSAYPEELSRVTASGFPVILS-----------APWYLDLISYGQD-------WR 461

  Fly   504 KVYDNSLKSIAGDYEHHVL--GAEGAIWSEQIDEHTLDNRFWPRASALAERLWSN-PAEGWRQAE 565
            |.|........|..:...|  |.|..:|.|.:|...|..|.||||||:.|||||: .......|.
Human   462 KYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAY 526

  Fly   566 SRLLLHRQRLVDNGLGAEAMQPQWCLQNEHE 596
            .||..||.|:|:.|:.|:.:...:|   .||
Human   527 DRLTRHRCRMVERGIAAQPLYAGYC---NHE 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hexo1	NP_523924.1	Glycohydro_20b2	69..190	CDD:291511	29/137 (21%)
		GH20_HexA_HexB-like	214..579	CDD:119332	130/376 (35%)
HEXB	NP_000512.2	Glycohydro_20b2	56..178	CDD:317278	29/137 (21%)
		GH20_HexA_HexB-like	200..540	CDD:119332	130/376 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146984
Domainoid	1	1.000	204	1.000	Domainoid score	I2952
eggNOG	1	0.900	-	-		E1_COG3525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3379
Isobase	1	0.950	-	0	Normalized mean entropy	S4676
OMA	1	1.010	-	-		QHG54329
OrthoDB	1	1.010	-	-		D164123at33208
OrthoFinder	1	1.000	-	-		FOG0001678
OrthoInspector	1	1.000	-	-		mtm8586
orthoMCL	1	0.900	-	-		OOG6_100456
Panther	1	1.100	-	-	O	PTHR22600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2560
SonicParanoid	1	1.000	-	-		X846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.790