DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hexo1 and HEXA

DIOPT Version :9

Sequence 1:	NP_523924.1	Gene:	Hexo1 / 38528	FlyBaseID:	FBgn0041630	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001305754.1	Gene:	HEXA / 3073	HGNCID:	4878	Length:	540	Species:	Homo sapiens

Alignment Length:	461	Identity:	157/461 - (34%)
Similarity:	232/461 - (50%)	Gaps:	62/461 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 TLDTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLIVYDDIRREVQVTANAT-INDAP 212
            ||::.|:|||.|:.|.     ..:.:...:||..||||.:||:...   .|.....|.| |.|.|
Human   120 TLESVENYTLTINDDQ-----CLLLSETVWGALRGLETFSQLVWKS---AEGTFFINKTEIEDFP 176

  Fly   213 VYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYSQ- 276
            .:..|||||||||:|..:.||..||:.||..|||.||||:.|..|||.|....|||.:.|:|:.
Human   177 RFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPV 241

  Fly   277 RQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHV---GEGWQHKNMTACFN-AQPWKSFCVEPPCG 337
            ..:||.:||.||:||.|:|||||:.|||.|.|.   |.|.... :|.|:: ::|..:|      |
Human   242 THIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGL-LTPCYSGSEPSGTF------G 299

  Fly   338 QLDPTVNEMYDVLEDIYGTMFDQFNPDIF-HMGGDEVSTSCWNSSQPIQQWMKKQGWGLETADFM 401
            .::|::|..|:.:...:..:...| ||.: |:|||||..:||.|:..||.:|:|:|:|   .||.
Human   300 PVNPSLNNTYEFMSTFFLEVSSVF-PDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFG---EDFK 360

  Fly   402 RLWGHFQTEALGRVDKVANGTHTPIILWTSGLTEEPFIDEY-LNPERYIIQIWTTGVDPKVKKIL 465
            :|...:....|..|.....|    .::|     :|.|.::. :.|:. |||:|...:.....|.|
Human   361 QLESFYIQTLLDIVSSYGKG----YVVW-----QEVFDNKVKIQPDT-IIQVWREDIPVNYMKEL 415

  Fly   466 E----RGYKIIVSNYDALYLDCGGAGW----VTDGNNWCSPYIGWQKVYDNSLKSIAGDYEHHVL 522
            |    .|::.::|           |.|    ::.|.:|...||.....::.:.:..|     .|:
Human   416 ELVTKAGFRALLS-----------APWYLNRISYGPDWKDFYIVEPLAFEGTPEQKA-----LVI 464

  Fly   523 GAEGAIWSEQIDEHTLDNRFWPRASALAERLWSNP-AEGWRQAESRLLLHRQRLVDNGLGAEAMQ 586
            |.|..:|.|.:|...|..|.||||.|:|||||||. ......|..||...|..|:..|:.|:.:.
Human   465 GGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLN 529

  Fly   587 PQWCLQ 592
            ..:|.|
Human   530 VGFCEQ 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hexo1	NP_523924.1	Glycohydro_20b2	69..190	CDD:291511	14/40 (35%)
Hexo1	NP_523924.1	GH20_HexA_HexB-like	214..579	CDD:119332	131/380 (34%)
HEXA	NP_001305754.1	Glycohydro_20b2	23..156	CDD:291511	14/40 (35%)
HEXA	NP_001305754.1	GH20_HexA_HexB-like	178..522	CDD:119332	131/380 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146986
Domainoid	1	1.000	204	1.000	Domainoid score	I2952
eggNOG	1	0.900	-	-		E1_COG3525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3379
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54329
OrthoDB	1	1.010	-	-		D164123at33208
OrthoFinder	1	1.000	-	-		FOG0001678
OrthoInspector	1	1.000	-	-		mtm8586
orthoMCL	1	0.900	-	-		OOG6_100456
Panther	1	1.100	-	-	O	PTHR22600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2560
SonicParanoid	1	1.000	-	-		X846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.840