DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hexo1 and Hexb

DIOPT Version :9

Sequence 1:	NP_523924.1	Gene:	Hexo1 / 38528	FlyBaseID:	FBgn0041630	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001011946.1	Gene:	Hexb / 294673	RGDID:	1307607	Length:	537	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	176/554 - (31%)
Similarity:	268/554 - (48%)	Gaps:	77/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LWPKPTGTVRLDTLMRQVDISF-IDFNFNGIARQQ-KLWRAVEDRFMNML---------EAQIPD 122
            |||.|........|:.....:| ||.:.|..|... .|......|:.|.:         .|:..|
  Rat    34 LWPMPRSVQVFPRLLYISPENFQIDNSPNSTAGPSCSLLLEAFRRYYNYIFGFYKRHHGPAKFQD 98

  Fly   123 RKVLARGGYRMSVNINTPDEPTPARLTLDTDESYTLDIDTDASGHVLANITASNFFGARHGLETL 187
            :..|.:  ..:.:|:....:..|   ::.:||||:|.:.     ..:|.:.|:..:||..||||.
  Rat    99 KPQLEK--LLVFINLEPQCDAFP---SMSSDESYSLLVQ-----EPVALLKANEVWGALRGLETF 153

  Fly   188 AQLIVYDDIRREVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHI 252
            :|| ||.|......:. .:||.|:|.:..||:|:||||:|..||:|.:||:.||..|.|..||||
  Rat   154 SQL-VYQDAYGTFTIN-ESTIADSPRFPHRGILIDTSRHYLPVKTIFKTLDAMAFNKFNVLHWHI 216

  Fly   253 TDSHSFPLEVKKRPELHKLGAYSQRQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHVGEGW---Q 314
            .|..|||.:....|||...|:||...|||..|:..|:||.|:|||||:||||:|.|. :.|   |
  Rat   217 VDDQSFPYQSITFPELSNKGSYSLSHVYTPNDIHMVLEYARLRGIRVIPEFDSPGHT-QSWGKGQ 280

  Fly   315 HKNMTACFNAQPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFNPDIF-HMGGDEVSTSCW 378
            ...:|.|| .|..::..|    |.:||::|..| |..|.:.....:..||.| |:|||||...||
  Rat   281 KNLLTPCF-IQKIRTQKV----GPVDPSLNTTY-VFFDTFFKEISRVFPDQFIHLGGDEVEFECW 339

  Fly   379 NSSQPIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVANGTHTPIILWTSGLTEEPFIDEYL 443
            .|:..||.:|||:|:|   .:|.||...:..:.|..:..:...:    |:|     ::.|.|:..
  Rat   340 ASNPNIQNFMKKKGFG---NNFRRLESFYIKKILDIITSLKKSS----IVW-----QDVFDDQVE 392

  Fly   444 NPERYIIQIWTTGVDPKVKKILERGYKIIVSNYDAL-----YLDCGGAGWVTDGNNWCSPYIGWQ 503
            .....::::|      |.:..|....::..|.:.|:     |||.     ::.|.:|.:.|....
  Rat   393 LQPGTVVEVW------KSENYLNELAQVTASGFPAILSAPWYLDL-----ISYGQDWRNYYKAEP 446

  Fly   504 KVYDNSLKSIAGDYEHHVLGAEGAIWSEQIDEHTLDNRFWPRASALAERLWS-----NPAEGWRQ 563
            ..::.|.|.     :..|:|.|..:|.|.:|...|..|.||||||:.|||||     |....:|
  Rat   447 LNFEGSEKQ-----KQLVIGGEACLWGEYVDATNLIPRLWPRASAVGERLWSPRIITNLENAYR- 505

  Fly   564 AESRLLLHRQRLVDNGLGAEAMQPQWC-LQNEHE 596
               ||.:||.|:|..|:.|:.:...:| .:|:.|
  Rat   506 ---RLAVHRCRMVSRGIAAQPLFTGYCNYENKME 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hexo1	NP_523924.1	Glycohydro_20b2	69..190	CDD:291511	31/131 (24%)
Hexo1	NP_523924.1	GH20_HexA_HexB-like	214..579	CDD:119332	131/378 (35%)
Hexb	NP_001011946.1	Glycohydro_20b2	34..156	CDD:291511	31/131 (24%)
Hexb	NP_001011946.1	GH20_HexA_HexB-like	178..518	CDD:119332	131/378 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340647
Domainoid	1	1.000	192	1.000	Domainoid score	I3112
eggNOG	1	0.900	-	-		E1_COG3525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	236	1.000	Inparanoid score	I3308
OMA	1	1.010	-	-		QHG54329
OrthoDB	1	1.010	-	-		D164123at33208
OrthoFinder	1	1.000	-	-		FOG0001678
OrthoInspector	1	1.000	-	-		mtm9062
orthoMCL	1	0.900	-	-		OOG6_100456
Panther	1	1.100	-	-	O	PTHR22600
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.810