DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hexo1 and hexb

DIOPT Version :9

Sequence 1:	NP_523924.1	Gene:	Hexo1 / 38528	FlyBaseID:	FBgn0041630	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001120459.1	Gene:	hexb / 100145770	XenbaseID:	XB-GENE-1002397	Length:	557	Species:	Xenopus tropicalis

Alignment Length:	610	Identity:	187/610 - (30%)
Similarity:	282/610 - (46%)	Gaps:	120/610 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RSGYCQKVELSEENYVKAISLPVCRLFCGSSIGTLWPKP-------------------------- 73
            ||...::::..||.....|.|.|.:   .|..|:|||.|
Frog    23 RSHSHRQLQGREEQLDTDIQLTVAQ---DSPFGSLWPLPQTVILSADSFYIPPSGFSIVHGSGST 84

  Fly    74 --TGTVRLDTLMRQVDISFIDFNFNGIARQQKLWRAVEDRFMN---MLEAQIPDRKVLARGGYRM 133
              |..|.|.:..|:    :.|:.| |.::    |:....:..|   :|:.|
Frog    85 AGTSCVLLQSAFRR----YYDYMF-GYSK----WKRASVKPSNAGQLLQLQ-------------- 126

  Fly   134 SVNINTPDEPTPARLTLDTDESYTLDIDTDASGHVLANITASNFFGARHGLETLAQLIVYDDIRR 198
             |.|.:.|.......|:.:||||.|.:     |..:|.:.|:..:||..||||.:||| |:| |.
Frog   127 -VVILSKDHQCHRYPTVQSDESYELSV-----GENVAVLKANQVWGALRGLETFSQLI-YED-RF 183

  Fly   199 EVQVTANATINDAPVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVK 263
            ...:...:.|.|.|.:..||:||||||:|..:|:|...|:.||..|.|.|||||.|..|||.:..
Frog   184 GAFLINKSYIEDFPRFAHRGILLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSV 248

  Fly   264 KRPELHKLGAY-SQRQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHVGEGW---QHKNMTACFNA 324
            ..|:|...|:| ....|||..||..|:||.|:|||||:||||:|.|. :.|   |...:|.|||.
Frog   249 TFPDLSDKGSYHPYTHVYTPVDVRLVIEYARMRGIRVVPEFDSPGHT-DSWGKGQQNLLTPCFNK 312

  Fly   325 QPWKSFCVEPPCGQLDPTVNEMYDVLEDIYGTMFDQFN------PDIF-HMGGDEVSTSCWNSSQ 382
                        |||......:..:|.|.|..|:..|.      ||.: |:|||||..|||.|:.
Frog   313 ------------GQLSGAYGPVNPILNDTYNFMYTFFQEVSNVFPDQYIHLGGDEVDFSCWKSNP 365

  Fly   383 PIQQWMKKQGWGLETADFMRLWGHFQTEALGRVDKVANGTHTPIILWTSGLTEEPFIDEY-LNPE 446
            .:.::|...|:|   .|:.:|..::..:.||.|..:..|    .::|     :|.|.:.. |||:
Frog   366 DVTKFMTDHGFG---TDYCKLESYYIQQVLGIVSSLKKG----YMVW-----QEVFDNNVKLNPD 418

  Fly   447 RYIIQIWTTGV-DPKVKKILERGYKIIVSNYDALYLDCGGAGWVTDGNNWCSPYIGWQKVYDNSL 510
            . ||::|...: ..::..:...|::.::|:  ..||:     .::.|.:|...|    ||...:.
Frog   419 T-IIEVWKEQLYQEEMAAVTAAGFQALLSS--PWYLN-----RISYGQDWIQVY----KVEPANF 471

  Fly   511 KSIAGDYEHHVLGAEGAIWSEQIDEHTLDNRFWPRASALAERLWSNP-AEGWRQAESRLLLHRQR 574
            ...| :.:..|:|.|..:|.|.:|...|..|.||||||:|||||||. ......|.:||:.||.|
Frog   472 NGTA-EQKQLVIGGEACMWGEFVDATNLTPRLWPRASAVAERLWSNQNVTSVGDAYNRLVKHRCR 535

  Fly   575 LVDNGLGAEAMQPQWCLQNEHECPI 599
            ::..|:.||.:...:|   :||..:
Frog   536 MLRRGIAAEPLYVGYC---DHELDV 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hexo1	NP_523924.1	Glycohydro_20b2	69..190	CDD:291511	33/151 (22%)
Hexo1	NP_523924.1	GH20_HexA_HexB-like	214..579	CDD:119332	130/378 (34%)
hexb	NP_001120459.1	Glycohydro_20b2	54..177	CDD:291511	33/151 (22%)
hexb	NP_001120459.1	GH20_HexA_HexB-like	199..540	CDD:119332	130/378 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3203
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	230	1.000	Inparanoid score	I3364
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164123at33208
OrthoFinder	1	1.000	-	-		FOG0001678
OrthoInspector	1	1.000	-	-		otm48237
Panther	1	1.100	-	-	O	PTHR22600
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2560
SonicParanoid	1	1.000	-	-		X846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190