DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIEbeta and gtf2e2

DIOPT Version :9

Sequence 1:	NP_523923.1	Gene:	TfIIEbeta / 38527	FlyBaseID:	FBgn0015829	Length:	292	Species:	Drosophila melanogaster
Sequence 2:	NP_997896.1	Gene:	gtf2e2 / 334854	ZFINID:	ZDB-GENE-030131-6794	Length:	291	Species:	Danio rerio

Alignment Length:	304	Identity:	162/304 - (53%)
Similarity:	202/304 - (66%)	Gaps:	30/304 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPALLREREAFKKRAMATPTVE--------------KKSKPDRPAPPPPSDDSRRKMRPPNAPR 51
            ||||||||||.|||||::||.||              ||||||:.:    |..|:....|.|.
Zfish     1 MDPALLRERELFKKRALSTPAVEKRPAASEASGSSKKKKSKPDKES----SSSSKNNSDPSNG-- 59

  Fly    52 LDATTYKTMSGSSQYRFGVLAKIVKFMRTRHQDGDDHPLTIDEILDETNQLDIGQSVKNWLASEA 116
              :...|.:||||.|:|||||:||.:|:||||.||.||||::||||||..||||...|.||.|||
Zfish    60 --SFNLKALSGSSGYKFGVLARIVNYMKTRHQRGDTHPLTLEEILDETKLLDIGMKQKQWLMSEA 122

  Fly   117 LHNNPKVEASPCGTKFSFKPVYKIKDGKTLMRLLKQHDLKGLGGILLDDVQESLPHCEKVLKNRS 181
            |.:|||::...  .|::|||.|.:||.|.|:|||.:||..||||:|||||:|.||:..|.:|...
Zfish   123 LASNPKIDVRE--GKYAFKPKYHLKDKKALLRLLDKHDQLGLGGVLLDDVEEGLPNAAKAIKALG 185

  Fly   182 AEILFVVRPIDKKKILFYNDRTANFSVDDEFQKLWRSATVDAMDDAKIDEYLEKQGIRSMQDHGL 246
            .:|:||.|| ||||||||||:...|.||:||||||||..||::|:.||:|||:||||.|||:.|.
Zfish   186 DQIIFVTRP-DKKKILFYNDKHCQFVVDEEFQKLWRSVPVDSIDEEKIEEYLKKQGISSMQETGP 249

  Fly   247 KKAIP--KRKK-AANKKRQFKKPRDNEHLADVLEVYEDNTLTLK 287
            ||..|  |||| ...:||::|  ..|:||..|||.|.|...:.|
Zfish   250 KKMTPIQKRKKPGTQRKRRYK--THNDHLNGVLEDYFDGVPSKK 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIEbeta	NP_523923.1	TFIIE_beta_winged_helix	61..141	CDD:153423	48/79 (61%)
gtf2e2	NP_997896.1	TFIIE_beta_winged_helix	67..145	CDD:153423	48/79 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581688
Domainoid	1	1.000	90	1.000	Domainoid score	I7783
eggNOG	1	0.900	-	-		E1_COG5174
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37573
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2958
OMA	1	1.010	-	-		QHG48945
OrthoDB	1	1.010	-	-		D1160863at2759
OrthoFinder	1	1.000	-	-		FOG0007303
OrthoInspector	1	1.000	-	-		oto39558
orthoMCL	1	0.900	-	-		OOG6_103945
Panther	1	1.100	-	-	LDO	PTHR12716
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1465
SonicParanoid	1	1.000	-	-		X4699
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800