Protein Alignment TfIIEbeta and GTF2E2

DIOPT Version :10

• Sequence 1: NP_523923.1
• Gene: TfIIEbeta / 38527
• FlyBaseID: FBgn0015829
• Length: 292
• Species: Drosophila melanogaster
• Sequence 2: NP_002086.1
• Gene: GTF2E2 / 2961
• HGNCID: 4651
• Length: 291
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 163/298 - (54%)
• Similarity: 208/298 - (69%)
• Gaps: 25/298 - (8%)

  Fly     1 MDPALLREREAFKKRAMATPTVEKKSKPDRPAPPPPSDDSRRKMR-----------PPNAPRLDA 54
            |||:||||||.|||||::||.|||:|     |....|..|.:|.:           ..|:...:.
Human     1 MDPSLLRERELFKKRALSTPVVEKRS-----ASSESSSSSSKKKKTKVEHGGSSGSKQNSDHSNG 60

  Fly    55 T-TYKTMSGSSQYRFGVLAKIVKFMRTRHQDGDDHPLTIDEILDETNQLDIGQSVKNWLASEALH 118
            : ..|.:||||.|:||||||||.:|:||||.||.||||:|||||||..||||...|.||.:|||.
Human    61 SFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLDEILDETQHLDIGLKQKQWLMTEALV 125

  Fly   119 NNPKVEASPCGTKFSFKPVYKIKDGKTLMRLLKQHDLKGLGGILLDDVQESLPHCEKVLKNRSAE 183
            ||||:|.  ...|::|||.|.::|.|.|:|||.|||.:|||||||:|::|:||:.:|.:|....:
Human   126 NNPKIEV--IDGKYAFKPKYNVRDKKALLRLLDQHDQRGLGGILLEDIEEALPNSQKAVKALGDQ 188

  Fly   184 ILFVVRPIDKKKILFYNDRTANFSVDDEFQKLWRSATVDAMDDAKIDEYLEKQGIRSMQDHGLKK 248
            ||||.|| |||||||:||::..||||:||||||||.|||:||:.||:|||::|||.|||:.|.||
Human   189 ILFVNRP-DKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKK 252

  Fly   249 AIP---KRKKAANKKRQFKKPRDNEHLADVLEVYEDNT 283
            ..|   ::|.|:.|||:||  ..|||||.||:.|.|.|
Human   253 VAPIQRRKKPASQKKRRFK--THNEHLAGVLKDYSDIT 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TfIIEbeta	NP_523923.1	TFIIE_beta_winged_helix	61..141	CDD:153423	51/79 (65%)
		TFA2_Winged_2	141..200	CDD:465658	35/58 (60%)
GTF2E2	NP_002086.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		25/66 (38%)
		TFIIE_beta_winged_helix	68..146	CDD:153423	51/79 (65%)
		TFA2_Winged_2	146..204	CDD:465658	35/58 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..272		14/30 (47%)