DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1316 and rbm45

DIOPT Version :9

Sequence 1:	NP_647887.1	Gene:	CG1316 / 38526	FlyBaseID:	FBgn0035526	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001120874.1	Gene:	rbm45 / 568524	ZFINID:	ZDB-GENE-070122-4	Length:	467	Species:	Danio rerio

Alignment Length:	468	Identity:	171/468 - (36%)
Similarity:	272/468 - (58%)	Gaps:	63/468 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DDPPMSRLFIICNKAHTEEDFREAFSPYGEIEDIWVVKDKHTQENKGIAYVKFSKTSDAAKAQEE 87
            |:||.||||::.:|:.||:..||:|:.:|||:||||||||.|:|:||:|::||:|:|.|..|.||
Zfish    12 DEPPNSRLFLVTSKSITEDTIRESFASFGEIQDIWVVKDKQTKESKGVAFIKFAKSSQACTAMEE 76

  Fly    88 MNGKTIGKMDRTLKVLVAANRNQGSNKSENEQEKYVRLFIVIPKTATEEDIREEFSQWGDVESVT 152
            |:|:.:.:..:.:||.:|.:|:.||:: :.|.|:..|:|::||||.||:|::|.|..:||:|...
Zfish    77 MHGRCLAEGTKPIKVFIAQSRSSGSHR-DVEDEELTRIFVMIPKTFTEDDLKETFKVYGDIEYAI 140

  Fly   153 IVKEKNNGNPKGFGYVRFTKFYYAAVAFENCSAKYKAVFAEPK-GSTRTQRDQYGRPSEDNPLYS 216
            |::.|..|:.||.|||||.|...||.|.|||...::|:.|||: .::....|.:..|....  :|
Zfish   141 IIRNKTTGDSKGLGYVRFHKPSQAAKAVENCDKTFRAIIAEPRTKNSSADNDYFSNPRTTE--HS 203

  Fly   217 SSGRGNSNFNGGGSSSGGGGSNSYNNDWNVSQNNDMAAFLRMQNVPVAQPSCLEVNVSNCVNQDQ 281
            :|..|:|::.....||....:.||::|                    ....||.|:....|:|:|
Zfish   204 TSELGSSSYAFAQESSSYSAAESYSSD--------------------IITRCLMVSSRVSVSQEQ 248

  Fly   282 LWRLFDIIPGLDYCQIMR-EHGPRTNEALVVYDNPEAAIYAKDKLHGLEYPMGERIIVKV----- 340
            ::.|||:|||||||:|.| ::|....:.:|.|.|..:|:|||:||:|.|||.|.|:.|..
Zfish   249 IYSLFDLIPGLDYCEIQRDQYGFSKGQVVVRYSNLGSAVYAKEKLNGFEYPPGNRLSVSFVDDGE 313

  Fly   341 -----------------------NGMSSAR-MDTSF------IDKRTKKDAICNVPLPPTQPLAS 375
                                   ||.|.:: |.||.      :.::.:.....|:|.|  :.|.:
Zfish   314 DRTSPVGKMAMQLVAAQMMSMVWNGPSGSQLMKTSAGYTAPPVPQKARLQTDANLPAP--KKLLA 376

  Fly   376 PDDQVAQRLFIVLSAN-LPHSILKNIFSCWSGLIDVYLLPNKNCGYVKYAEVESAQLAIRTLNGA 439
            .|..|.:|||::.:.: ||..:|:::|..:..||:|||:|.:|.||:|||:..||..||.|::|.
Zfish   377 LDSVVKERLFVIFNPSPLPVEVLEDVFCRFGSLIEVYLVPGRNVGYIKYADRRSAHDAIDTMHGK 441

  Fly   440 EICGTKIKVMEAE 452
            .:.|.|:|||.|:
Zfish   442 VVNGVKMKVMLAD 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1316	NP_647887.1	RRM1_RBM45	25..105	CDD:240812	40/79 (51%)
		RRM2_RBM45	122..195	CDD:240813	34/72 (47%)
		RRM3_RBM45	267..339	CDD:240814	34/72 (47%)
		RRM4_RBM45	383..449	CDD:240815	28/66 (42%)
rbm45	NP_001120874.1	RRM1_RBM45	14..94	CDD:240812	40/79 (51%)
		RRM2_RBM45	110..183	CDD:240813	34/72 (47%)
		RRM3_RBM45	234..307	CDD:240814	34/72 (47%)
		RRM4_RBM45	384..451	CDD:240815	28/66 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579310
Domainoid	1	1.000	75	1.000	Domainoid score	I9033
eggNOG	1	0.900	-	-		E1_2CAJT
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15560
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2716
OMA	1	1.010	-	-		QHG48842
OrthoDB	1	1.010	-	-		D299261at33208
OrthoFinder	1	1.000	-	-		FOG0007975
OrthoInspector	1	1.000	-	-		oto41176
orthoMCL	1	0.900	-	-		OOG6_108069
Panther	1	1.100	-	-	LDO	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5751
SonicParanoid	1	1.000	-	-		X5918
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800