DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1316 and PSPC1

DIOPT Version :9

Sequence 1:	NP_647887.1	Gene:	CG1316 / 38526	FlyBaseID:	FBgn0035526	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001035879.1	Gene:	PSPC1 / 55269	HGNCID:	20320	Length:	523	Species:	Homo sapiens

Alignment Length:	200	Identity:	50/200 - (25%)
Similarity:	84/200 - (42%)	Gaps:	43/200 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TEEDFREAFSPYGEIEDIWVVKDKHTQENKGIAYVKFSKTSDAAKAQEEMNGKTIGKMDRTLKVL 103
            |||||:..|..|||..::::.:|      :|..:::....:.|..|:.|::| ||.| .|.|::.
Human    94 TEEDFKRLFERYGEPSEVFINRD------RGFGFIRLESRTLAEIAKAELDG-TILK-SRPLRIR 150

  Fly   104 VAANRNQGSNKSENEQEKYVRLFIVIPKTATEEDIREEFSQWGDVESVTIVKEKNNGNPKGFGYV 168
            .|.:....:.|:             :....:.|.:.:.|||:|.||...:|.: :.|...|.|:|
Human   151 FATHGAALTVKN-------------LSPVVSNELLEQAFSQFGPVEKAVVVVD-DRGRATGKGFV 201

  Fly   169 RFTKFYYAAVAFENC-------SAKYKAVFAEP------------KGSTRTQRDQYGRPSEDNPL 214
            .|.....|..|.|.|       :...:.|..||            |...:||  ||.:..|..|.
Human   202 EFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQ--QYHKEREQPPR 264

  Fly   215 YSSSG 219
            ::..|
Human   265 FAQPG 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1316	NP_647887.1	RRM1_RBM45	25..105	CDD:240812	20/65 (31%)
		RRM2_RBM45	122..195	CDD:240813	20/91 (22%)
		RRM3_RBM45	267..339	CDD:240814
		RRM4_RBM45	383..449	CDD:240815
PSPC1	NP_001035879.1	RRM1_PSP1	81..151	CDD:241030	20/64 (31%)
		Sufficient for paraspeckles localization	125..358		38/162 (23%)
		RRM2_PSP1	157..236	CDD:241033	21/92 (23%)
		NOPS_PSPC1	227..320	CDD:240584	10/44 (23%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000269\|PubMed:16148043	231..358		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910