DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1316 and elavl2

DIOPT Version :9

Sequence 1:	NP_647887.1	Gene:	CG1316 / 38526	FlyBaseID:	FBgn0035526	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001002172.2	Gene:	elavl2 / 431719	ZFINID:	ZDB-GENE-040704-9	Length:	389	Species:	Danio rerio

Alignment Length:	378	Identity:	87/378 - (23%)
Similarity:	160/378 - (42%)	Gaps:	67/378 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GGQEYSNDDDPPM--------SRLFIICN---KAHTEEDFREAFSPYGEIEDIWVVKDKHTQENK 68
            |....||....|:        |:..:|.|   :..|:|:.:..|...||||...:|:||.|.::.
Zfish    45 GPNSVSNTCTSPVEMPNGSEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSL 109

  Fly    69 GIAYVKFSKTSDAAKAQEEMNGKTIGKMDRTLKVLVAANRNQGSNKSENEQEKYVRLFIVIPKTA 133
            |..:|.:.:..||.||...:||..:  ..:|:||..|    :.|:.|..:...||.   .:|||.
Zfish   110 GYGFVNYMEPKDAEKAINTLNGLRL--QTKTIKVSYA----RPSSASIRDANLYVS---GLPKTM 165

  Fly   134 TEEDIREEFSQWGDVESVTIVKEKNNGNPKGFGYVRFTKFYYAAVAFENCSAKYKAVFAEPKGST 198
            |::::.:.|||:|.:.:..|:.::..|..:|.|::||.:...|..|.:..:.:      :|.|:|
Zfish   166 TQKELEQLFSQFGRIITSRILVDQVTGVSRGVGFIRFDRRVEAEEAIKGLNGQ------KPPGAT 224

  Fly   199 RTQRDQY-GRPSEDNP------LYSSSGR--------GNSNFNGGGSSSGGGGSNSYNNDWNVSQ 248
            .....:: ..||:.:.      ||.|..|        ....|......:...|..|..:...:..
Zfish   225 EPITVKFANNPSQKSSQALLSHLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKSRFSPMTIDG 289

  Fly   249 NNDMAAFLRMQNVPVAQPS--CLEV-NVSNCVNQDQLWRLFDIIPGLDYCQIMREHGPRTNE--- 307
            ...:|..    |:|....:  |:.| |::...:::.||::|.....:...:::|:.  .||:
Zfish   290 VTSLAGI----NLPAHAGTGWCIFVYNLAPDADENVLWQMFGPFGAVTNVKVIRDF--NTNKCKG 348

  Fly   308 -ALVVYDNPEAAIYAKDKLHGLEYPMGERIIVKVNGMSSARMDTSFIDKRTKK 359
             ..|...|.:.|..|...|:|  |.:|:|:           :..||...:|.|
Zfish   349 FGFVTMTNYDEAAVAIASLNG--YRLGDRV-----------LQVSFKTNKTHK 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1316	NP_647887.1	RRM1_RBM45	25..105	CDD:240812	26/90 (29%)
		RRM2_RBM45	122..195	CDD:240813	18/72 (25%)
		RRM3_RBM45	267..339	CDD:240814	18/78 (23%)
		RRM4_RBM45	383..449	CDD:240815
elavl2	NP_001002172.2	ELAV_HUD_SF	65..388	CDD:273741	82/356 (23%)
		RRM1_Hu	67..144	CDD:241094	24/78 (31%)
		RRM2_HuB	149..238	CDD:241219	24/97 (25%)
		RRM_SF	303..388	CDD:302621	21/99 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910