DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1316 and Rbm45

DIOPT Version :9

Sequence 1:	NP_647887.1	Gene:	CG1316 / 38526	FlyBaseID:	FBgn0035526	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_700454.1	Gene:	Rbm45 / 241490	MGIID:	2387367	Length:	476	Species:	Mus musculus

Alignment Length:	495	Identity:	178/495 - (35%)
Similarity:	272/495 - (54%)	Gaps:	75/495 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDYRSQSRSGGGRGGQEYSNDDDPPMSRLFIICNKAHTEEDFREAFSPYGEIEDIWVVKDKHTQ 65
            |.|......|||.|.|.:  :.|:||.||:|::.:|..:|...||.|||:|:|:|||||:||||:
Mouse     1 MDDAGGLGGSGGFRPGVD--SLDEPPNSRIFLVISKHTSELVLRERFSPFGDIQDIWVVRDKHTK 63

  Fly    66 ENKGIAYVKFSKTSDAAKAQEEMNGKTIGKMD-RTLKVLVAANRNQGSNKSENEQEKYVRLFIVI 129
            |:||:|:|||:::|.|.:|.|||:|:.:|..| :.:||.:|.:|:.||:: :.|.|:..|:|::|
Mouse    64 ESKGVAFVKFARSSQACRAMEEMHGQCLGPSDTKPIKVFIAQSRSSGSHR-DVEDEELTRIFVMI 127

  Fly   130 PKTATEEDIREEFSQWGDVESVTIVKEKNNGNPKGFGYVRFTKFYYAAVAFENCSAKYKAVFAEP 194
            ||:.||||:||:|..:||:|..:|:|.|..|..||.||||:.|...||.|.|||...::|:.|||
Mouse   128 PKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDRSFRALLAEP 192

  Fly   195 KGSTRTQRDQYGRPSEDNPLYSSSGRGNSNFNGGGSSSGG-----------GGSNSYNNDWNVSQ 248
            |....      |.|.:|:  |||          |...:.|           |...|..:.::.:.
Mouse   193 KNKVS------GSPEQDD--YSS----------GRQEALGQEPRANLFPFVGEQQSEFSTFDKND 239

  Fly   249 NNDMAAFLRMQNVPVAQPSCLEVNVSNCVNQDQLWRLFDIIPGLDYCQIMREHGPRTNEALVVYD 313
            :....|..:..:|....|          ..::||:.:|||:|||:||::.|:........:|.|.
Mouse   240 SRGQEAVSKRLSVVSRVP----------FTEEQLFSIFDIVPGLEYCEVPRDPYSNYGHGVVQYF 294

  Fly   314 NPEAAIYAKDKLHGLEYPMGERIIVK---------------VNGMSSARMDTSFIDKRTKKDAI- 362
            |..:|||||.||||.:||.|.||:|.               ...|.:|:: .|.:...|.:...
Mouse   295 NVASAIYAKYKLHGFQYPPGNRIVVSFLDDGSNMTELIRKMATQMVAAQL-ASMVWSTTSQQQFL 358

  Fly   363 --------------CNVPLPPTQPLASPDDQVAQRLFIVLSAN-LPHSILKNIFSCWSGLIDVYL 412
                          .:|.||..:..|.|:..|.:|||:|.:.: ||..:|::||..:..||:|||
Mouse   359 QYGGNAASQAPQIQTDVVLPSCKKKAPPETPVKERLFVVFNPHPLPLDVLEDIFCRFGNLIEVYL 423

  Fly   413 LPNKNCGYVKYAEVESAQLAIRTLNGAEICGTKIKVMEAE 452
            :..||.||||||:.:||..||.||:|..:.|.::|||.|:
Mouse   424 VSGKNVGYVKYADRKSANEAITTLHGKILNGVRLKVMLAD 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1316	NP_647887.1	RRM1_RBM45	25..105	CDD:240812	41/80 (51%)
		RRM2_RBM45	122..195	CDD:240813	35/72 (49%)
		RRM3_RBM45	267..339	CDD:240814	28/71 (39%)
		RRM4_RBM45	383..449	CDD:240815	31/66 (47%)
Rbm45	NP_700454.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		7/20 (35%)
		RRM1_RBM45	23..104	CDD:240812	41/80 (51%)
		RRM2_RBM45	120..193	CDD:240813	35/72 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..212		9/37 (24%)
		RRM3_RBM45	248..320	CDD:240814	30/81 (37%)
		RRM4_RBM45	393..460	CDD:240815	31/66 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835915
Domainoid	1	1.000	79	1.000	Domainoid score	I8705
eggNOG	1	0.900	-	-		E1_2CAJT
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15560
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2846
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48842
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007975
OrthoInspector	1	1.000	-	-		oto94783
orthoMCL	1	0.900	-	-		OOG6_108069
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5751
SonicParanoid	1	1.000	-	-		X5918
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.690