DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl1 and Slc44a1

DIOPT Version :9

Sequence 1:	NP_647884.1	Gene:	Ctl1 / 38523	FlyBaseID:	FBgn0035523	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_038966811.1	Gene:	Slc44a1 / 85254	RGDID:	621426	Length:	723	Species:	Rattus norvegicus

Alignment Length:	636	Identity:	223/636 - (35%)
Similarity:	353/636 - (55%)	Gaps:	64/636 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLRIINGYDSFGNTCGVKYNEKFQGFPLSGMNTL 85
            |||||..||.::::|.:.:..|..||...|...|:::||||:||.||.: |.|.:....||::..
  Rat    28 RSCTDIPWLLLFVLFCIGMGFICGFSVATGAAARLVSGYDSYGNICGQR-NAKLEAIANSGLDHT 91

  Fly    86 DKPELFYFD------VKELKKSLKICVKSCPAKTMTKGSELLEYYSQTGTQLCKYDYNMQQLTTA 144
            .:..:|:.|      :....||:.:||.:||.:.:...|::.::....|:.||.|:....:.|..
  Rat    92 HRKYVFFLDPCNLDLINRKIKSMALCVAACPRQELKTLSDVQKFAEINGSALCSYNIKPSEYTLT 156

  Fly   145 GNDAKTFNFLGPCPSFPVHESSPV--LHRCVPKGT---GEKVQNYYDMLNNWDVAQQFVGDIYST 204
               ||:..|   ||..||..|:|:  .|||.|...   .:..:.....:::..|..:.:..:.::
  Rat   157 ---AKSSAF---CPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTS 215

  Fly   205 WHIIAMVCGLALLISIALVTMMHWLSRIVSWIICVLVIVASVALTVALWYAYYNIR---NKSGVN 266
            ..||..:|.|:|::|:.|:.::.::||::.||:.:|||:.|:..|..||:.|...|   .::.:.
  Rat   216 KEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKETVIP 280

  Fly   267 TQYSMLEEFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNLPGLLIAP 331
            .|..:.|:   |.:|:|..|:.||:..:||.:::..::.::|...|||..||:..::||.|:..|
  Rat   281 EQLQIAED---NLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQP 342

  Fly   332 LLAFLVLIAFLSFWVAVIICLATASSPGQSPIAPFDNSKAHQQPLPANALFVSNSTDVNDLRPNA 396
            ...|..|:.|.::|:..::.|.|..|..|:                                ...
  Rat   343 FWTFFALVLFWAYWIMTLLFLGTTGSAVQN--------------------------------EQG 375

  Fly   397 RVEYADAGVLRSMFWIYVVGLIWTVEFIFACQQFALAAAVAFWYFQKPTS----TPTFYAIGKLV 457
            .|||..:|.|:.|:|.:||||||..|||.||||..:|.||..:||.:...    ||...::.:|:
  Rat   376 FVEYKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLI 440

  Fly   458 KYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKCCICGFWLLEKFIRFLNH 522
            :|||||||||||:||:.||||:||.|::::||   .|.:.||.|.||.|||..|.|||.:.:||.
  Rat   441 RYHLGTVAKGSFIITLVKIPRMILMYIHSQLK---GKENACARCMLKSCICCLWCLEKCLSYLNQ 502

  Fly   523 NAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVVVAALSGLIGIVLLKDKP 587
            ||||..||.|.|||.:|..|:..:..|.|:||.||:||||:||||||::...:||.||:||..:.
  Rat   503 NAYTATAINSTNFCTSAKDAFVILVENALRVAAINTVGDFMLFLGKVLIVCSTGLAGIMLLNYQQ 567

  Fly   588 GLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLN-GRSGR 637
            ....::.|:||:.:|:|.:||..||::|||||.||||...|...| |..||
  Rat   568 DYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGR 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	34/111 (31%)
Ctl1	NP_647884.1	Choline_transpo	286..629	CDD:282384	140/346 (40%)
Slc44a1	XP_038966811.1	Choline_transpo	298..608	CDD:398290	139/344 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	265	1.000	Domainoid score	I1826
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11137
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1899
OMA	1	1.010	-	-		QHG45602
OrthoDB	1	1.010	-	-		D167290at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm45896
orthoMCL	1	0.900	-	-		OOG6_104769
Panther	1	1.100	-	-	LDO	PTHR12385
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2976
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.980