DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl1 and Slc44a2

DIOPT Version :9

Sequence 1:	NP_647884.1	Gene:	Ctl1 / 38523	FlyBaseID:	FBgn0035523	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_011240895.1	Gene:	Slc44a2 / 68682	MGIID:	1915932	Length:	733	Species:	Mus musculus

Alignment Length:	732	Identity:	197/732 - (26%)
Similarity:	339/732 - (46%)	Gaps:	148/732 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AESKDGE--------GEAQNNRPKY------RSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLR 54
            |:|..|:        |..|...|.:      |.|||.....:..:..:..:.:.|.::.:|:|.:
Mouse    19 ADSASGQLFQEPPFFGTPQKYDPTFKGPIYNRGCTDVICCVLLFLAIVGYVAVGIIAWTHGDPRK 83

  Fly    55 IINGYDSFGNTCGVKYNEKFQGFPLSGMNTLDKPELFYFDVKELKKSL----------KICVKSC 109
            :|...||.|..||.|           |....|||.||||::.:....|          :||||.|
Mouse    84 VIYPTDSRGEFCGQK-----------GTKNADKPFLFYFNIVKCANPLVLLEFHCPTPQICVKQC 137

  Fly   110 PAKTMT----KGSELLEYYSQ---TGTQLCKYDYNMQQLTTAGNDAKTFNFLGPCPSFPVHESSP 167
            |.:.:|    :.:...:||.|   .|.|      |.:.:|....|       |.||:. :..|.|
Mouse   138 PDRYLTLLSARNTRDFDYYKQFCVPGFQ------NNKGVTEILRD-------GECPAV-ITPSKP 188

  Fly   168 VLHRCVP-----KGT------------------------GEKVQNYYDMLNNWDVAQQFVGDIYS 203
            :..||.|     ||.                        |.|..|  .:|....:|.|...|...
Mouse   189 LAQRCFPAIHASKGVLMVGNETTYEDGHGARKNITDLVEGAKKAN--KILEARQLAMQIFEDYTV 251

  Fly   204 TWHIIAMVCGLALLISIALVTMMHWLSRIVSWIICVLVIVASVALTVALWYAYY---NIRNKSGV 265
            :|:.|.:...:|:::|:..:.::.:|:.|:.|::.|:||   :.|...:::.|.   .:|.::|.
Mouse   252 SWYWIIIGLVIAMVLSLLFIVLLRFLAGIMVWVMIVMVI---LVLGYGIFHCYMEYSRLRGEAGS 313

  Fly   266 NTQ------YSMLEEFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNL 324
            :..      .:.|..::..:|..:...::.:|..:::|:::.||:.::....||.:||.:.:.::
Mouse   314 DVSLVDLGFQTDLRVYLHLRQTWMAFMIILSILEVVIILLLIFLRKRILIAIALIKEASRAVGHV 378

  Fly   325 PGLLIAPLLAFLVLIAFLSFWVAVIICLATASSPGQSPI----APFDNSKAHQQPLPANALFVSN 385
            ...|:.||:.|.:|...:::|.:..:.|:|:::.....:    .|......:.:..|
Mouse   379 MCSLLYPLVTFFLLCLCIAYWASTSVFLSTSNTAVYKVVDDTACPLLRKTCNPETFP-------- 435

  Fly   386 STDVNDLR------PNARVEYADAGVLRSMFWIYVVGL--------IWTVEFIFACQQFALAAAV 436
                  ||      |.||.::|..|. .|.:...::||        .|...|:.|..|..||.|.
Mouse   436 ------LRNESLQCPTARCQFAFYGG-ESTYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAF 493

  Fly   437 A--FWYFQKPTSTPT---FYAIGKLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGS 496
            |  :|..:||...|.   |.|.|:.::||.|::|.||.::.|.:|.|::|.||..:||..::|.:
Mouse   494 ASYYWAMRKPDDMPAFPLFSAFGRALRYHTGSLAFGSLILAIVQIIRVMLEYLDQRLKAAQNKFA 558

  Fly   497 ECAACCLKCCICGFWLLEKFIRFLNHNAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGD 561
            :....|||||   ||.|||||:|||.|||.::||...|||.:|..|:..:..|:::||.::.|.|
Mouse   559 KFLMVCLKCC---FWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTD 620

  Fly   562 FILFLGKVVVAALSGLIG-------IVLLKD-KPGLNFYMAPVIIIIIFSFFIAHIILSLFEMVV 618
            |:..|||:::....|::.       |.:::| .|.||:|..|::.:||.|:.|||...|::.|.|
Mouse   621 FLFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIIGSYLIAHGFFSVYGMCV 685

  Fly   619 DTLFLCVCEDKTLNGRS 635
            ||||||.|||...|..|
Mouse   686 DTLFLCFCEDLERNDGS 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	21/117 (18%)
Ctl1	NP_647884.1	Choline_transpo	286..629	CDD:282384	117/373 (31%)
Slc44a2	XP_011240895.1	ABC_6TM_exporters	<258..>298	CDD:365789	9/42 (21%)
Slc44a2	XP_011240895.1	Choline_transpo	341..697	CDD:398290	118/373 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329225at2759
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820