DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl1 and SLC44A2

DIOPT Version :9

Sequence 1:	NP_647884.1	Gene:	Ctl1 / 38523	FlyBaseID:	FBgn0035523	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001350540.1	Gene:	SLC44A2 / 57153	HGNCID:	17292	Length:	711	Species:	Homo sapiens

Alignment Length:	714	Identity:	202/714 - (28%)
Similarity:	344/714 - (48%)	Gaps:	134/714 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GEAQNNRPKY------RSCTDTCWLAIYIIFWLFLIV----IAIFSFVYGNPLRIINGYDSFGNT 65
            |..|...|.:      |.|||    .|..:|.|..||    :.|.::.:|:|.::|...||.|..
Human    13 GTPQKYDPTFKGPIYNRGCTD----IICCVFLLLAIVGYVAVGIIAWTHGDPRKVIYPTDSRGEF 73

  Fly    66 CGVKYNEKFQGFPLSGMNTLDKPELFYFDVKELKKSL----------KICVKSCPAKTMT----K 116
            ||.|           |....:||.||||::.:....|          :|||:.||.:.:|    :
Human    74 CGQK-----------GTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRYLTYLNAR 127

  Fly   117 GSELLEYYSQTGTQLCKYDY-NMQQLTTAGNDAKTFNFLGPCPSFPVHESSPVLHRCVP-----K 175
            .|...|||.    |.|...: |.:.:.....|       |.||:..: .|.|:..||.|     |
Human   128 SSRDFEYYK----QFCVPGFKNNKGVAEVLQD-------GDCPAVLI-PSKPLARRCFPAIHAYK 180

  Fly   176 GT------------------------GEKVQNYYDMLNNWDVAQQFVGDIYSTWHIIAMVCGLAL 216
            |.                        |.|..|  .:|....:|.:...|...:|:.|.:...:|:
Human   181 GVLMVGNETTYEDGHGSRKNITDLVEGAKKAN--GVLEARQLAMRIFEDYTVSWYWIIIGLVIAM 243

  Fly   217 LISIALVTMMHWLSRIVSWIICVLVIVASVALTVALWYAYY---NIRNKSGVNTQYSMLE----- 273
            .:|:..:.::.:|:.|:.|::.::||   :.|...:::.|.   .:|.::|  :..|:::
Human   244 AMSLLFIILLRFLAGIMVWVMIIMVI---LVLGYGIFHCYMEYSRLRGEAG--SDVSLVDLGFQT 303

  Fly   274 ---EFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNLPGLLIAPLLAF 335
               .::..:|..|...::.:|..:|:|:::.||:.::....||.:||.:.:..:...|:.||:.|
Human   304 DFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTF 368

  Fly   336 LVLIAFLSFWVAVIICLATASSPGQSPIAPFDNSKAHQQPLPANALFVSNST--DVNDLR--PNA 396
            .:|...:::|.:..:.|:|::   ::....||:|     |.|..|...:..|  ..|:.|  |||
Human   369 FLLCLCIAYWASTAVFLSTSN---EAVYKIFDDS-----PCPFTAKTCNPETFPSSNESRQCPNA 425

  Fly   397 RVEYA----DAGVLRSMFWIYVVG---LIWTVEFIFACQQFALAAAVA--FWYFQKPTSTPT--- 449
            |.::|    ::|..|::..:.:..   ..|...|:.|..|..||.|.|  :|..:||...|.
Human   426 RCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRKPDDLPAFPL 490

  Fly   450 FYAIGKLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKCCICGFWLLE 514
            |.|.|:.::||.|::|.|:.::.|.:|.|:||.||..:||..|:|.::|...|||||   ||.||
Human   491 FSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCLMTCLKCC---FWCLE 552

  Fly   515 KFIRFLNHNAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVVVAALSGLIG 579
            |||:|||.|||.::||...|||.:|..|:..:..|:::||.::.|.||:..|||:::....|::.
Human   553 KFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVGILA 617

  Fly   580 -------IVLLKD-KPGLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLNGRS 635
                   |.:::| .|.||:|..|::.:|:.|:.|||...|::.|.|||||||.|||...|..|
Human   618 FFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVYGMCVDTLFLCFCEDLERNDGS 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	22/119 (18%)
Ctl1	NP_647884.1	Choline_transpo	286..629	CDD:282384	123/366 (34%)
SLC44A2	NP_001350540.1	Choline_transpo	337..675	CDD:309592	118/348 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329225at2759
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820