DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl1 and slc44a5a

DIOPT Version :9

Sequence 1:	NP_647884.1	Gene:	Ctl1 / 38523	FlyBaseID:	FBgn0035523	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_696562.6	Gene:	slc44a5a / 568158	ZFINID:	ZDB-GENE-070705-333	Length:	715	Species:	Danio rerio

Alignment Length:	734	Identity:	202/734 - (27%)
Similarity:	332/734 - (45%)	Gaps:	126/734 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GEAQNNRPKY------RSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLRIINGYDSFGNTCGVK 69
            ||.:...|.:      |.|||.....:::|..|..|.:...::::|:|.::|...||.|..||.|
Zfish    13 GEPRKFDPTFRGPVYNRGCTDVLCCVLFVIVILGYIALGTVAWIHGDPRKVIYPTDSTGQFCGQK 77

  Fly    70 YNEKFQGFPLSGMNTLDKPELFYFDVKELKK----------SLKICVKSCPAKTMT-KGSELL-- 121
                       |.....|..||||::.:...          :.::||..||.:..| ...:||
Zfish    78 -----------GTPNAKKAILFYFNILKCASPAVLINLQCPTTQMCVSKCPDRFATYTDMQLLYR 131

  Fly   122 ------EYYSQTGTQLCKYDYNMQQLTTA----GNDAKTFNFLGPCPSFPVHESSPVLHRCVPK- 175
                  :||.    |.||..:|..|.:.|    ..|         |||..| .|.|.|.||.|.
Zfish   132 FNKSHWDYYK----QFCKPGFNNPQKSVAQVLRDED---------CPSMIV-PSRPFLQRCFPDF 182

  Fly   176 -------------------GTGEKVQNYYDMLNN-------WDVAQQFVGDIYSTWHIIAMVCGL 214
                               .|...|....|..|.       .:|..:.|.|..|.|:.|.:...:
Zfish   183 ITRNGTLTVANKTAFKDALDTARSVTELRDAANGITSIHEAKEVGMKIVEDYASCWYWIVIGLFI 247

  Fly   215 ALLISIALVTMMHWLSRIVSWIICVLVIVASVALTVALWYAYYN---IRNKSGVNTQYS------ 270
            ||:||:..:.::.:.:..:.|.|...||   :.:...:|:.|:.   :|...|.:...|
Zfish   248 ALVISLIFILLLRFTAGFLLWFIIFAVI---LLVAYGIWHCYWEFAVLRETPGADVTISDIGFQT 309

  Fly   271 MLEEFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNLPGLLIAPLLAF 335
            .|..:::..|..|...|...:|...:::::.||:.::....||..|..:.:..:...|..|::.|
Zfish   310 DLHVYLQLSQTWLVFMVTLGLTEASIVLMLIFLRKRVRIAIALLREGSRAISYIMSALFYPIITF 374

  Fly   336 LVLIAFLSFWVAVIICLATASSPGQSPIAPFDNSK-AHQQPLPANALFVSNSTDVNDLRPNARVE 399
            ::|...:|:|....:.||::........:...|.| |:|...|.:    .|.|::....|.|:..
Zfish   375 VLLAICISYWAMTALFLASSGDAVYKVASGNPNCKYANQTCSPES----FNRTNITKQCPGAQCL 435

  Fly   400 YADAGVLRSMF--WIYVVGL------IWTVEFIFACQQFALAAAVA--FWYFQKPTS---TPTFY 451
            :|..|. .|::  :|:::.|      :|.|.|..|..|..:|.|.|  :|..:||..   .|.|.
Zfish   436 FAFYGG-ESLYHRYIFILQLCNLLVFLWLVNFTIALGQCTVAGAFASYYWARRKPADIPPCPVFS 499

  Fly   452 AIGKLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKCCICGFWLLEKF 516
            :..:.::||.|::|.||.::.:.::.|:||.||..|||...:..:....||||||   ||.||:|
Zfish   500 SFSRALRYHTGSLAFGSLILAVVQLIRVILEYLDHKLKGAHNAFARFLLCCLKCC---FWCLERF 561

  Fly   517 IRFLNHNAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVVVAALSGLIGIV 581
            |||:|.|||.::||...|||.:|..|:..:..||::||.::.|.||:|||||:::|...|:|...
Zfish   562 IRFMNRNAYIMIAIYGKNFCTSAREAFYLLMRNVVRVAVLDKVTDFLLFLGKLLIAGSVGVIAFF 626

  Fly   582 LLKDK--------PGLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLN-GRSGR 637
            |...|        |.||:|..|::.:|:.|:.|||...|::.|.|||||||.|||...| |.:.:
Zfish   627 LFTRKIPIIQEEVPVLNYYCVPLLTVILGSYLIAHSFFSVYAMCVDTLFLCFCEDLERNDGTTAK 691

  Fly   638 --WAQSNLAKLVGEEPLQP 654
              :....|.:::|:....|
Zfish   692 PFFMSPGLKRILGKAEQSP 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	23/117 (20%)
Ctl1	NP_647884.1	Choline_transpo	286..629	CDD:282384	119/364 (33%)
slc44a5a	XP_696562.6	Choline_transpo	335..682	CDD:282384	117/354 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329225at2759
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820