DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl1 and Slc44a2

DIOPT Version :9

Sequence 1:	NP_647884.1	Gene:	Ctl1 / 38523	FlyBaseID:	FBgn0035523	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_006242711.1	Gene:	Slc44a2 / 363024	RGDID:	1309680	Length:	711	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	201/746 - (26%)
Similarity:	354/746 - (47%)	Gaps:	130/746 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KDGE------GEAQNNRPKY------RSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLRIINGY 59
            ||.:      |..|...|.:      |.|||.....:..:..:..:.:.|.::.:|:|.::|...
  Rat     3 KDSQHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVLLFLAIVGYVAVGIIAWTHGDPRKVIYPT 67

  Fly    60 DSFGNTCGVKYNEKFQGFPLSGMNTLDKPELFYFDVKELKKSL----------KICVKSCPAKTM 114
            ||.|..||.|           |....|||.||||::.:....|          :||||.||.:.:
  Rat    68 DSRGEFCGQK-----------GTKNADKPFLFYFNIVKCASPLVLLEFHCPTPQICVKQCPDRYL 121

  Fly   115 T----KGSELLEYYSQTGTQLCKYDY-NMQQLTTAGNDAKTFNFLGPCPSFPVHESSPVLHRCVP 174
            |    :.|...:||.    |.|...: |.:.:.....|       |.||:. :..|.|:..||.|
  Rat   122 TFLSARNSRDFDYYK----QFCVPGFKNNKGVAEVLRD-------GECPAV-IIPSKPLAQRCFP 174

  Fly   175 --------------------KGTGEKVQNYYD-------MLNNWDVAQQFVGDIYSTWHIIAMVC 212
                                .||.:.|.:..:       :|....:|.|...|...:|:.|.:..
  Rat   175 AIHASKGVLMVGNETTYEDGHGTRKNVTDLVEGAKKANKVLEARQLAMQIFEDYTVSWYWIVIGL 239

  Fly   213 GLALLISIALVTMMHWLSRIVSWIICVLVIVASVALTVALWYAYYN-IRNKSGVNTQ------YS 270
            .:|:|:|:..:.::.:|:.::.|::.|:||:. :...:...||.|: :|.::|.:..      .:
  Rat   240 VIAMLLSLMFIVLLRFLAGVMVWVMIVMVILV-LGYGIFHCYAEYSRLRGEAGSDVSLVDLGFQT 303

  Fly   271 MLEEFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNLPGLLIAPLLAF 335
            .|..::..:|..:...::.:|..:::|:::.||:.::....||.:||.:.:.::...::.||:.|
  Rat   304 DLRVYLHLRQTWMAFMIILSILEVVIILLLIFLRKRILIAIALIKEASRAVGHVMCSMLYPLVTF 368

  Fly   336 LVLIAFLSFWVAVIICLATASSPGQSPIAPF---DNSKAHQQPLPANALFVSNST-DVNDLR--P 394
            .:|...:::|.:..:.|:|      |.:|.:   |::     |.|......:..| .:|:.|  |
  Rat   369 FLLCLCIAYWASTSVFLST------SNVAVYKIVDDT-----PCPLLGKTCNPETFPLNESRQCP 422

  Fly   395 NARVEYADAGVLRSMFWIYVVGL--------IWTVEFIFACQQFALAAAVA--FWYFQKPTSTPT 449
            |.|.::|..|. .|.:...::||        .|...|:.|..|..||.|.|  :|..:||...|.
  Rat   423 NGRCQFAFYGG-ESTYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWAMRKPDDMPA 486

  Fly   450 ---FYAIGKLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKCCICGFW 511
               |.|.|:.::||.|::|.||.::.|.:|.|::|.||..:||..::|.::....|||||   ||
  Rat   487 FPLFSAFGRALRYHTGSLAFGSLILAIVQIIRVMLEYLDQRLKAAQNKFAKFLMVCLKCC---FW 548

  Fly   512 LLEKFIRFLNHNAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVVVAALSG 576
            .|||||:|||.|||.::||...|||.:|..|:..:..|:::||.::.|.||:..|||:::....|
  Rat   549 CLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDFLFLLGKLLIVGSVG 613

  Fly   577 LIG-------IVLLKD-KPGLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLNG 633
            ::.       |.:::| .|.||:|..|::.:||.|:.|||...|::.|.|||||||.|||...|.
  Rat   614 ILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIIGSYLIAHGFFSVYGMCVDTLFLCFCEDLERND 678

  Fly   634 RSGR---WAQSNLAKLVGEEPLQPGEEPPIE 661
            .|..   :....|..::.:...|.|::..:|
  Rat   679 GSQERPYFMSPELKDILLKGSSQAGKQEEVE 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	22/115 (19%)
Ctl1	NP_647884.1	Choline_transpo	286..629	CDD:282384	120/369 (33%)
Slc44a2	XP_006242711.1	Choline_transpo	320..675	CDD:398290	121/369 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329225at2759
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820