DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl1 and zgc:63569

DIOPT Version :9

Sequence 1:	NP_647884.1	Gene:	Ctl1 / 38523	FlyBaseID:	FBgn0035523	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_942572.1	Gene:	zgc:63569 / 321056	ZFINID:	ZDB-GENE-030131-9816	Length:	697	Species:	Danio rerio

Alignment Length:	709	Identity:	196/709 - (27%)
Similarity:	336/709 - (47%)	Gaps:	115/709 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ESKDGEGEAQNNRPKY------RSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLRIINGYDSFG 63
            |.|...||.:...|.:      |.|||.....|:||..|..:.:.|.::.:|:|.::|...||.|
Zfish     4 EEKPKYGEPRKFDPSFKGPIQNRGCTDIVCCIIFIIAILGYLAVGILAWTHGDPRKVIYPTDSMG 68

  Fly    64 NTCGVKYNEKFQGFPLSGMNTLDKPELFYFDVKELKKSL----------KICVKSCPAKTMTKGS 118
            ..||....||             :|.||||::.:....:          ::||::||.:|||..:
Zfish    69 QFCGQGKLEK-------------QPFLFYFNMMKCASPMVLLEFQCPTPQVCVQTCPNRTMTLIT 120

  Fly   119 EL-----LEYYSQTGTQLCKYDYNMQQLTTAGNDAKTFNFLGP--CPSFPVHESSPVLHRCVPK- 175
            .:     .|||.    ..||.|        .|:.|.. ..|..  ||::.| .|:|.|.||.|.
Zfish   121 AISKPQDWEYYK----SYCKED--------PGHKAAA-QILKEKLCPAYLV-SSNPFLQRCFPSM 171

  Fly   176 ---------GTGEKVQNYYDMLNNWD----------------VAQQFVGDIYSTWHIIAMVCGLA 215
                     |..||..:..::|:..|                ||.:...|...:|:.|.:...:|
Zfish   172 GKKGEVITVGDQEKFSDGVNVLDAKDLMAGMKNASIVMEGRQVAMKIFEDYTKSWYWILICLLIA 236

  Fly   216 LLISIALVTMMHWLSRIVSWIICVLVIVASVALTVA-LWYAYYNIRNKSGVNTQYSML------E 273
            :::|:..:.::.:|:.::.|:: :|::||.:|..:| ....|.::::..|.|.....|      .
Zfish   237 VVLSLIFIVLLRFLAGVMVWVM-ILMVVAVIAYGIAHCSIKYVSLKDTPGSNITLQQLGFQPDFA 300

  Fly   274 EFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNLPGLLIAPLLAFLVL 338
            .::..:|..|...::..|..:|:|:::.||:|::.....|.:||.:.:..:...|:.|:..|.:|
Zfish   301 VYLHIRQTWLAFIIILAILELIIILLLIFLRNRIRVAVELMKEASRAIGYVMSSLVFPIFTFFLL 365

  Fly   339 IAFLSFWVAVIICLATASSPGQSPIAPFDNSKAHQQPLPANALFVSNSTDVNDLRPNARVEYADA 403
            ...::||....:.|:|:|.|........:...:.:...|.|....|..:|.    |:::..:|..
Zfish   366 AIVIAFWGVNAVFLSTSSEPVYKVFNETECVHSRETCNPENFTSSSMKSDC----PHSQCLFAFY 426

  Fly   404 G---------VLRSMFWIYVVGLIWTVEFIFACQQFALAAAVA--FWYFQKPTSTPTF---YAIG 454
            |         :|...:.:::  ..|...|:.|..|..||.|.|  :|.|.|....|.|   .::|
Zfish   427 GGETPYHKYLILLQFYNVFL--FFWCANFVTALGQMTLAGAFASYYWAFDKSKDMPAFPLCASLG 489

  Fly   455 KLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKCCICGFWLLEKFIRF 519
            :.::||.|::|.||.::.|.::.|::|.|:..|||..|:|.::...||||||   ||.|||||:|
Zfish   490 RSLRYHTGSLAFGSLLLAIVQVIRVLLEYIDHKLKGAENKFAKFLLCCLKCC---FWCLEKFIKF 551

  Fly   520 LNHNAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVVVAALSGLIGIVLLK 584
            :|.|||.:|||...|||.:|..|:..:..||::|..::.|.||||||||:::..|.|:.......
Zfish   552 INRNAYIMVAIYGKNFCRSARDAFFLLMRNVVRVVVLDKVTDFILFLGKLLIVGLVGIFAFFFFS 616

  Fly   585 DK--------PGLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLNGRS 635
            .:        |.|::|..|::.:::.|:.|||...|::.|.|||||||..||...|..|
Zfish   617 GQTDAFKGTAPSLHYYWVPILTVLVCSYLIAHGFFSVYAMCVDTLFLCFLEDLERNDGS 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	23/115 (20%)
Ctl1	NP_647884.1	Choline_transpo	286..629	CDD:282384	114/364 (31%)
zgc:63569	NP_942572.1	Choline_transpo	331..669	CDD:282384	109/346 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329225at2759
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010