DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl1 and Slc44a4

DIOPT Version :9

Sequence 1:	NP_647884.1	Gene:	Ctl1 / 38523	FlyBaseID:	FBgn0035523	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_997706.1	Gene:	Slc44a4 / 294255	RGDID:	1303167	Length:	707	Species:	Rattus norvegicus

Alignment Length:	736	Identity:	212/736 - (28%)
Similarity:	346/736 - (47%)	Gaps:	136/736 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KDGEGEAQNNRPKY----------RSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLRIINGYDS 61
            |..|.||..|..||          |.|||.....::::|.|..||:.:.::|||:|.:::...:|
  Rat     4 KQKENEAYGNSAKYDPSFRGPIKNRGCTDIICCVLFLVFILGYIVVGLVAWVYGDPRQVLYPRNS 68

  Fly    62 FGNTCGVKYNEKFQGFPLSGMNTLDKPELFYFDVKELKKSL---------------KICVKSCP- 110
            .|..|||..|:             |||.:.||::.....::               ::||.|||
  Rat    69 TGAYCGVGDNK-------------DKPYVLYFNILSCAAAINVISIAENGLQCPTPQVCVSSCPQ 120

  Fly   111 AKTMTKGSELLEYYSQTGTQLCKYDYNMQQLTTAGNDAKTFNFL--GPCPSFPVHESSPVLHRCV 173
            ...:.:|.:|    |.|...:.| :|....:.....|....:.|  |.|||| :..|:|.|.||.
  Rat   121 TPWVVEGFQL----SNTVGDVYK-EYRNFCVPAVSPDMVVMDSLQKGLCPSF-LLPSTPALGRCF 179

  Fly   174 P--------------------KGTGEKVQNYYDMLNNWDVAQQFVGDIYSTWHIIAMVCGLALLI 218
            |                    ||    :....|.:|..||:.:...|...:|:.|.:..|:||::
  Rat   180 PLPNINFTLPEQLQINNTTVSKG----ISGLLDSINARDVSVKIFEDFAQSWYWILVALGVALVL 240

  Fly   219 SIALVTMMHWLSRIVSWIICVLVIVASVALTV----ALWYAYYNIRNKSGVNTQYSMLEEFVRNQ 279
            |:..:.::    |:|:..:.:|:||..:|:..    ..|..|..:|::....||..........|
  Rat   241 SLLFILLL----RLVAAPLVLLLIVGVLAVLAYGIYHCWQQYRELRDQGVSITQLGFTANLSAYQ 301

  Fly   280 Q-------AVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNLPGLLIAPLLAFLV 337
            .       |::.||||..:.:::||    ||:.::....||.:||.:.:..:...:..||:.|::
  Rat   302 NVKETWLAALIILAVLEGVLLLMLI----FLRQRIRIAIALLKEASRAVGQMMSTMFYPLVTFVL 362

  Fly   338 LIAFLSFWVAVIICLATASSPGQSPIAPFDNSKAHQQPLP-ANALFVSNSTD----VNDLRPNAR 397
            |:..:.:|....:.|||:..|...       ...|....| ...:.|:.|.|    :|...|..:
  Rat   363 LVICIGYWAVTALYLATSGQPQYV-------YWVHNTSTPGCEKVLVNVSCDPMAPLNSSCPELK 420

  Fly   398 ---VEYADAGVL-RSMF--WIY-VVGLIWTVEFIFACQQFALAAAVA--FWYFQKPTSTPTF--- 450
               ..|:.:|:. ||:|  .|| ::||.|||.::.|..|..||.|.|  :|.|.||...|||
  Rat   421 CTFTGYSSSGLAQRSLFNLQIYGILGLFWTVNWVLALGQCVLAGAFASFYWAFHKPRDIPTFPLS 485

  Fly   451 YAIGKLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKCCICGFWLLEK 515
            .|..:.::||.|::|.|:.::|:.:|.|:||.|:..||:..::..:.|..||.|||:   |.|||
  Rat   486 SAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGSQNPVARCIICCFKCCL---WCLEK 547

  Fly   516 FIRFLNHNAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVVVAALSGLIGI 580
            ||:|||.|||.::||...|||.:|..|:..:..||::|..::.|.|.:||.||::|.   |.:|:
  Rat   548 FIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNVVRVVVLDKVTDLLLFFGKLLVV---GGVGV 609

  Fly   581 V-----------LLKD--KPGLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLN 632
            :           |.||  .|.||:|..|::..|:.::.||....|:|.|.|||||||..||...|
  Rat   610 LSFFFFSGRIKGLGKDFKNPDLNYYWLPIMTSIMGAYVIASGFFSVFGMCVDTLFLCFLEDLERN 674

  Fly   633 GRSGR---WAQSNLAKLVGEE 650
            ..|..   :....|.|::|::
  Rat   675 DGSQERPYYMPKALLKILGKK 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	28/119 (24%)
Ctl1	NP_647884.1	Choline_transpo	286..629	CDD:282384	125/372 (34%)
Slc44a4	NP_997706.1	Choline_transpo	311..671	CDD:282384	126/376 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329225at2759
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820