Protein Alignment Ctl1 and SLC44A1

DIOPT Version :9

• Sequence 1: NP_647884.1
• Gene: Ctl1 / 38523
• FlyBaseID: FBgn0035523
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: XP_006717090.1
• Gene: SLC44A1 / 23446
• HGNCID: 18798
• Length: 737
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 225/633 - (35%)
• Similarity: 349/633 - (55%)
• Gaps: 58/633 - (9%)

  Fly    21 RSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLRIINGYDSFGNTCGVKYNEKFQGFPLSGMNTL 85
            |||||..||.::|:|.:.:..|..||...|...|:::||||:||.||.| |.|.:..|.|||:..
Human    42 RSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQK-NTKLEAIPNSGMDHT 105

  Fly    86 DKPELFYFD------VKELKKSLKICVKSCPAKTMTKGSELLEYYSQTGTQLCKYDYNMQQLTTA 144
            .:..:|:.|      :....||:.:||.:||.:.:...|::.::....|:.||.|:....:.||:
Human   106 QRKYVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTS 170

  Fly   145 GNDAKTFNFLGPCPSFPVHESSPV--LHRCVPKGT---GEKVQNYYDMLNNWDVAQQFVGDIYST 204
            ...:..      ||..||..|:|:  .|||.|...   .:..:.....:::..|..:.:..:.::
Human   171 PKSSVL------CPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTS 229

  Fly   205 WHIIAMVCGLALLISIALVTMMHWLSRIVSWIICVLVIVASVALTVALWYAYYNIRNKSGVNTQY 269
            ..||..:|.|:|::|:.|:.::.::||::.||:.:|||:.|:..|..||:.|...|.........
Human   230 KEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKETVTP 294

  Fly   270 SMLEEFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNLPGLLIAPLLA 334
            ..|:....|.:|:|..|:.||:..:||.:::..::.::|...|||..||:..::||.|:..|...
Human   295 EQLQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWT 359

  Fly   335 FLVLIAFLSFWVAVIICLATASSPGQSPIAPFDNSKAHQQPLPANALFVSNSTDVNDLRPNARVE 399
            |..|:.|..:|:..::.|.|..||.|:                                ....||
Human   360 FFALVLFWVYWIMTLLFLGTTGSPVQN--------------------------------EQGFVE 392

  Fly   400 YADAGVLRSMFWIYVVGLIWTVEFIFACQQFALAAAVAFWYFQKPTS----TPTFYAIGKLVKYH 460
            :..:|.|:.|:|.:||||||..|||.||||..:|.||..:||.:...    ||...::.:|::||
Human   393 FKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYH 457

  Fly   461 LGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKCCICGFWLLEKFIRFLNHNAY 525
            |||||||||:||:.||||:||.|::::||   .|.:.||.|.||.|||..|.|||.:.:||.|||
Human   458 LGTVAKGSFIITLVKIPRMILMYIHSQLK---GKENACARCVLKSCICCLWCLEKCLNYLNQNAY 519

  Fly   526 TVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVVVAALSGLIGIVLLKDKPGLN 590
            |..||.|.|||.:|..|:..:..|.|:|||||:||||:||||||::...:||.||:||..:....
Human   520 TATAINSTNFCTSAKDAFVILVENALRVATINTVGDFMLFLGKVLIVCSTGLAGIMLLNYQQDYT 584

  Fly   591 FYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLN-GRSGR 637
            .::.|:||:.:|:|.:||..||::|||||.||||...|...| |..||
Human   585 VWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGR 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	33/108 (31%)
		Choline_transpo	286..629	CDD:282384	141/346 (41%)
SLC44A1	XP_006717090.1	Choline_transpo	311..622	CDD:282384	141/345 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1871
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11137
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1901
Isobase	1	0.950	-	0	Normalized mean entropy	S5638
OMA	1	1.010	-	-		QHG45602
OrthoDB	1	1.010	-	-		D167290at33208
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	1	1.000	-	-		otm41764
orthoMCL	1	0.900	-	-		OOG6_104769
Panther	1	1.100	-	-	LDO	PTHR12385
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4525
SonicParanoid	1	1.000	-	-		X2976
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820