DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl1 and SLC44A5

DIOPT Version :9

Sequence 1:	NP_647884.1	Gene:	Ctl1 / 38523	FlyBaseID:	FBgn0035523	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_016856096.1	Gene:	SLC44A5 / 204962	HGNCID:	28524	Length:	726	Species:	Homo sapiens

Alignment Length:	734	Identity:	205/734 - (27%)
Similarity:	338/734 - (46%)	Gaps:	126/734 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DGEGEAQNNRPKYRSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLRIINGYDSFGNTCGVKYNE 72
            |.:|...|     |||||.....|:::..:..||:.:.::|:|:|.|.....||.|:.||.|
Human    33 DFKGPVAN-----RSCTDVLCCMIFLLCIIGYIVLGLVAWVHGDPRRAAYPTDSQGHFCGQK--- 89

  Fly    73 KFQGFPLSGMNTLDKPELFYFDVKELKK----------SLKICVKSCPAKTMTKGSELLEY---- 123
                    |....:|..||||::.....          :.:|||..||.|.:|.....|.|
Human    90 --------GTPNENKTILFYFNLLRCTSPSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDK 146

  Fly   124 -YSQTGTQLCKYDYNMQQLTTAGNDAKTFNFL---GPCPS--FPVHESSPVLHRCVP-----KGT 177
             |.:...|.||         |.....|:...|   ..||:  ||   |.|.|.||.|     .||
Human   147 SYWEDYRQFCK---------TTAKPVKSLTQLLLDDDCPTAIFP---SKPFLQRCFPDFSTKNGT 199

  Fly   178 ---GEKVQNYYD--------------------MLNNWDVAQQFVGDIYSTWHIIAMVCGLALLIS 219
               |.|:. :.|                    :|:...:..:...|...||:.|.:...:|:::|
Human   200 LTIGSKMM-FQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYARTWYWILIGLTIAMVLS 263

  Fly   220 IALVTMMHWLSRIVSWIICVLVIVASVALTVALWYAYYNIRNKS------------GVNTQYSML 272
            ...:.::.:::..:.|:..:.||   ..:...:|:.|....|..            |:.|..||.
Human   264 WIFLILLRFIAGCLFWVFMIGVI---GIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMY 325

  Fly   273 EEFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNLPGLLIAPLLAFLV 337
            .|.   ||...|..::..|..:|:|:::.||:|::.....|.:|..:.:..:|..|:.|.|.|::
Human   326 FEL---QQTWFTFMIILCIIEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFIL 387

  Fly   338 LIAFLSFWVAVIICLATASSPGQSPIAPFDNSKAHQQPLPANALFVSNSTDVNDLRPNARVEYAD 402
            |...:.:||...:.|||:..|....|||..:. .|:.......:|  |:|::....|.|...:|.
Human   388 LSICICYWVVTAVFLATSGVPVYKVIAPGGHC-IHENQTCDPEIF--NTTEIAKACPGALCNFAF 449

  Fly   403 AGVLRSMFWIYV--------VGLIWTVEFIFACQQFALAAAVA--FWYFQKPTST---PTFYAIG 454
            .|. :|::..|:        ...:|.:.|:.|..|.|||.|.|  :|..:||...   |.|.|.|
Human   450 YGG-KSLYHQYIPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPDDIPRYPLFTAFG 513

  Fly   455 KLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKCCICGFWLLEKFIRF 519
            :.::||.|::|.||.:|.:.::.:::|.||..:||:.::..|:...|||:||   ||.||..|:|
Human   514 RAIRYHTGSLAFGSLIIALIQMFKIVLEYLDHRLKRTQNTLSKFLQCCLRCC---FWCLENAIKF 575

  Fly   520 LNHNAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVVVAALSGLIGI---- 580
            ||.|||.::||...|||.:|..|:|.:..|||:||..:.|..|:|||||::||...|::..
Human   576 LNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVAVTDEVTYFVLFLGKLLVAGSIGVLAFLFFT 640

  Fly   581 ----VLLKDKPGLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLNGRSGR---W 638
                |:.:....||:|..|::.:|..|:.|||...|::.|.|:|:|:|.|||...|..|..   :
Human   641 QRLPVIAQGPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICFCEDLERNDGSTEKPYF 705

  Fly   639 AQSNLAKLVGEEPLQPGEE 657
            ...||..::.::.|.|.::
Human   706 VTPNLHGILIKKQLVPQKQ 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	24/120 (20%)
Ctl1	NP_647884.1	Choline_transpo	286..629	CDD:282384	119/363 (33%)
SLC44A5	XP_016856096.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329225at2759
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820