DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ctl1 and chtl-1

DIOPT Version :9

Sequence 1:	NP_647884.1	Gene:	Ctl1 / 38523	FlyBaseID:	FBgn0035523	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001367417.1	Gene:	chtl-1 / 180809	WormBaseID:	WBGene00018037	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	706	Identity:	177/706 - (25%)
Similarity:	306/706 - (43%)	Gaps:	117/706 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AQNNRPKY---RSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLRIINGYDSFGNTCGVKYNEKF 74
            |:.:.|:.   |.|||.....::.:|....:|:|.|..::|:|.|:|...||....|||.....:
Worm    76 AKRHNPQLYTKRGCTDVFCCFLFFVFLCGWVVVAGFGIMWGDPQRLIYPTDSEFRRCGVNLEGSY 140

  Fly    75 QGFPLSGMNTLDKPELFYFDVKEL---------KKSLKICVKSCPAKTMTKGSELLEYYSQTGTQ 130
                    |...:|.|||||:.:.         .::.::|||.||       |....|.......
Worm   141 --------NFSKRPYLFYFDLTKCISYATALGGCQTTQLCVKECP-------STYFSYLQLRTAS 190

  Fly   131 LCKYDYNMQQLTTAGND-----AKTFNFL------GPCPSFPVHE-SSPVLHRCVPKGTGEKVQN 183
            :.:....|:.:....:|     ..||..|      |.|.|:.|.. ..|||.||.|:.....|.|
Worm   191 VSEIQNKMKSVVYCTDDVDKTTVTTFQALQNLVQRGKCVSYTVKSVPVPVLQRCFPEAIFNAVDN 255

  Fly   184 YYDMLNNWD-------------------------------------VAQQFVGDIYSTWHIIAMV 211
            ..::||:.:                                     |..:.:.|:..||....::
Worm   256 VNNVLNSSNSLDYLKRTFGDDALIPQDIQITGQSSEVMKSVVEDQPVTHKVIHDLSQTWWQTLIL 320

  Fly   212 CGLALLISIALVTMMHWLSRIVSWIICVLVIVASVALTVALWYAYYNIRNKSGVNTQYSM---LE 273
            ...|.::|.....:|..|..::.| :.:|:::.::.......:..:|....:|....||.   .:
Worm   321 IFAAGILSFIWTVIMRLLGSLIIW-LSILIVLVALGFGAGFSWLKWNTLKTTGAIDDYSFHPAFD 384

  Fly   274 EFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALFEEAGQCMMNLPGLLIAPLLAFLVL 338
            .:.......|.:|:..::.::|.::||.|::.:::...||..|:.:.:.::...|:.||..||:.
Worm   385 AYFEMPTTWLVVAIATSVLLLIFLLVILFIRQRISIACALISESSKAIGSMMSTLLFPLFPFLLH 449

  Fly   339 IAFLSFWVAVIICLATASSPGQSPIAPFDNSKAHQQPLPANALFVSNSTDVNDLRPNARVEYADA 403
            |...:.|.::.|.||   |.||...          :....|....:.||..:.........|  .
Worm   450 IGVFALWGSIAIWLA---SSGQEVC----------RLKETNGQVYNTSTKCDCTAKVTGCTY--V 499

  Fly   404 GVLR---SMFWIYVVGL---IWTVEFIFACQQFALAAAVA--FWYFQKPTSTPTF---YAIGKLV 457
            |:.:   ::||:.|..|   .|...|:.|....|||.|.|  :|...|....|||   .|:.:.:
Worm   500 GIEKESETIFWLQVYNLFAFFWLSCFVTALGDIALAGAFASYYWARDKRHDVPTFPVIRALNRAI 564

  Fly   458 KYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKCCICGFWLLEKFIRFLNH 522
            :|:||::|.||.:|.|.||.|::|.|:..||.|.::|..:....|||||   ||.||.|.:||..
Worm   565 RYNLGSIAFGSLIIAIVKIIRVLLEYIDHKLGKSQNKAVKWFLMCLKCC---FWCLEVFFKFLTK 626

  Fly   523 NAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVVVAALSGLIG-------- 579
            |||.::||...||..:|..::..:..|:::...::.|...:|||||.::....|::.
Worm   627 NAYIMIAIYGKNFFSSAKDSFLLITRNIVRTVVVHKVAGILLFLGKSMITLGMGILSFYYFSGRW 691

  Fly   580 IVLLKDKPGLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLNGRS 635
            :|....|..|.:|..|::|::|.|:|:|.:...::||.|||.|:|..||...|..|
Worm   692 VVEGVPKVDLYYYFVPIVIVVIGSYFMADLFFDVYEMAVDTTFICFLEDSEQNDGS 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	18/111 (16%)
Ctl1	NP_647884.1	Choline_transpo	286..629	CDD:282384	107/361 (30%)
chtl-1	NP_001367417.1	Choline_transpo	415..742	CDD:398290	103/344 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D329225at2759
OrthoFinder	1	1.000	-	-		FOG0000381
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920