Protein Alignment Ctl1 and SLC44A3

DIOPT Version :10

• Sequence 1: NP_647884.1
• Gene: Ctl1 / 38523
• FlyBaseID: FBgn0035523
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001107578.1
• Gene: SLC44A3 / 126969
• HGNCID: 28689
• Length: 653
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 206/650 - (31%)
• Similarity: 324/650 - (49%)
• Gaps: 73/650 - (11%)

  Fly     6 SKDGEGEAQNNRPK-YRSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLRIINGYDSFGNTCGVK 69
            |.:|....:..||: ||.||||.||.::.:||..|:.|..:|.|.|...|::.|||||||.|| |
Human    11 SAEGAPRQREWRPQIYRKCTDTAWLFLFFLFWTGLVFIMGYSVVAGAAGRLLFGYDSFGNMCG-K 74

  Fly    70 YNEKFQGFPLSGMNTLDKPELFYFDVKELK------KSLKICVKSCPAKTMTKGSELLEYYSQTG 128
            .|...:|.||||.:...|..:|:.:...|:      ..:.:||.:||.:.:....|:..:.:.:|
Human    75 KNSPVEGAPLSGQDMTLKKHVFFMNSCNLEVKGTQLNRMALCVSNCPEEQLDSLEEVQFFANTSG 139

  Fly   129 TQLCKYDYNMQQLTTAGNDAKTFNFL-GP-----CPSFPV--HESSPVLHRCVPKGTGEKVQNYY 185
            :.||.|..|            :||:. .|     ||..||  .:|.|:.:||||: |.|....:.
Human   140 SFLCVYSLN------------SFNYTHSPKADSLCPRLPVPPSKSFPLFNRCVPQ-TPECYSLFA 191

  Fly   186 DML-NNWDVAQQFVGDIYSTWHIIAMVCGLALLISIALVTMMHWLSRIVSWIICVLVIVASVALT 249
            .:| |:.|...:.:..|.|....|..:|.|||.:|:|::....:::.::..|...|||:..:.:.
Human   192 SVLINDVDTLHRILSGIMSGRDTILGLCILALALSLAMMFTFRFITTLLVHIFISLVILGLLFVC 256

  Fly   250 VALWYAYYNIRNKSGVNTQYSMLEEFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALF 314
            ..||:.||:..|...:.     |:....|.:.||..|:::|....:|:|:|:.|:.::.....||
Human   257 GVLWWLYYDYTNDLSIE-----LDTERENMKCVLGFAIVSTGITAVLLVLIFVLRKRIKLTVELF 316

  Fly   315 EEAGQCMMNLPGLLIAPLLAFLVLIAFLSFWVAVIICLATASSPGQSPIAPFDNSKAHQQPLPAN 379
            :...:.:.:.|.||..||..|.:||.|...||||::.|.||.:.
Human   317 QITNKAISSAPFLLFQPLWTFAILIFFWVLWVAVLLSLGTAGAA--------------------- 360

  Fly   380 ALFVSNSTDVNDLRPNARVEYADAGVLRSMFWIYVVGLIWTVEFIFACQQFALAAAVAFWYFQK- 443
                       .:....:|||.....:|.|:..:::|||||.|||.||||..:|.||...||.:
Human   361 -----------QVMEGGQVEYKPLSGIRYMWSYHLIGLIWTSEFILACQQMTIAGAVVTCYFNRS 414

  Fly   444 ---PTSTPTFYAIGKLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKC 505
               |...|...::..|..||.|||.||||:|::.:|||:|:.|:...||  |.:....:....:|
Human   415 KNDPPDHPILSSLSILFFYHQGTVVKGSFLISVVRIPRIIVMYMQNALK--EQQHGALSRYLFRC 477

  Fly   506 CICGFWLLEKFIRFLNHNAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVV 570
            |.|.||.|:|::..||.||||..||...:||.:|..|:..::.|.....:||..||||:|||||:
Human   478 CYCCFWCLDKYLLHLNQNAYTTTAINGTDFCTSAKDAFKILSKNSSHFTSINCFGDFIIFLGKVL 542

  Fly   571 VAALSGLIGIVLLKDKPGLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLNGRS 635
            |...:...|::..........:..|::::..|::.:||..||:||.|:|.||||...|...|..|
Human   543 VVCFTVFGGLMAFNYNRAFQVWAVPLLLVAFFAYLVAHSFLSVFETVLDALFLCFAVDLETNDGS 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	Choline_transpo	287..629	CDD:461337	113/345 (33%)
SLC44A3	NP_001107578.1	MdlB	<192..>363	CDD:440747	49/207 (24%)
		Choline_transpo	289..602	CDD:461337	114/346 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..653