Protein Alignment Ctl1 and SLC44A3

DIOPT Version :9

• Sequence 1: NP_647884.1
• Gene: Ctl1 / 38523
• FlyBaseID: FBgn0035523
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001107578.1
• Gene: SLC44A3 / 126969
• HGNCID: 28689
• Length: 653
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 206/650 - (31%)
• Similarity: 324/650 - (49%)
• Gaps: 73/650 - (11%)

  Fly     6 SKDGEGEAQNNRPK-YRSCTDTCWLAIYIIFWLFLIVIAIFSFVYGNPLRIINGYDSFGNTCGVK 69
            |.:|....:..||: ||.||||.||.::.:||..|:.|..:|.|.|...|::.|||||||.|| |
Human    11 SAEGAPRQREWRPQIYRKCTDTAWLFLFFLFWTGLVFIMGYSVVAGAAGRLLFGYDSFGNMCG-K 74

  Fly    70 YNEKFQGFPLSGMNTLDKPELFYFDVKELK------KSLKICVKSCPAKTMTKGSELLEYYSQTG 128
            .|...:|.||||.:...|..:|:.:...|:      ..:.:||.:||.:.:....|:..:.:.:|
Human    75 KNSPVEGAPLSGQDMTLKKHVFFMNSCNLEVKGTQLNRMALCVSNCPEEQLDSLEEVQFFANTSG 139

  Fly   129 TQLCKYDYNMQQLTTAGNDAKTFNFL-GP-----CPSFPV--HESSPVLHRCVPKGTGEKVQNYY 185
            :.||.|..|            :||:. .|     ||..||  .:|.|:.:||||: |.|....:.
Human   140 SFLCVYSLN------------SFNYTHSPKADSLCPRLPVPPSKSFPLFNRCVPQ-TPECYSLFA 191

  Fly   186 DML-NNWDVAQQFVGDIYSTWHIIAMVCGLALLISIALVTMMHWLSRIVSWIICVLVIVASVALT 249
            .:| |:.|...:.:..|.|....|..:|.|||.:|:|::....:::.::..|...|||:..:.:.
Human   192 SVLINDVDTLHRILSGIMSGRDTILGLCILALALSLAMMFTFRFITTLLVHIFISLVILGLLFVC 256

  Fly   250 VALWYAYYNIRNKSGVNTQYSMLEEFVRNQQAVLTLAVLATITMIILIVVIYFLKNKLAGLSALF 314
            ..||:.||:..|...:.     |:....|.:.||..|:::|....:|:|:|:.|:.::.....||
Human   257 GVLWWLYYDYTNDLSIE-----LDTERENMKCVLGFAIVSTGITAVLLVLIFVLRKRIKLTVELF 316

  Fly   315 EEAGQCMMNLPGLLIAPLLAFLVLIAFLSFWVAVIICLATASSPGQSPIAPFDNSKAHQQPLPAN 379
            :...:.:.:.|.||..||..|.:||.|...||||::.|.||.:.
Human   317 QITNKAISSAPFLLFQPLWTFAILIFFWVLWVAVLLSLGTAGAA--------------------- 360

  Fly   380 ALFVSNSTDVNDLRPNARVEYADAGVLRSMFWIYVVGLIWTVEFIFACQQFALAAAVAFWYFQK- 443
                       .:....:|||.....:|.|:..:::|||||.|||.||||..:|.||...||.:
Human   361 -----------QVMEGGQVEYKPLSGIRYMWSYHLIGLIWTSEFILACQQMTIAGAVVTCYFNRS 414

  Fly   444 ---PTSTPTFYAIGKLVKYHLGTVAKGSFVITIFKIPRLILTYLYAKLKKGEDKGSECAACCLKC 505
               |...|...::..|..||.|||.||||:|::.:|||:|:.|:...||  |.:....:....:|
Human   415 KNDPPDHPILSSLSILFFYHQGTVVKGSFLISVVRIPRIIVMYMQNALK--EQQHGALSRYLFRC 477

  Fly   506 CICGFWLLEKFIRFLNHNAYTVVAIESINFCPAAGIAWNAMATNVLQVATINSVGDFILFLGKVV 570
            |.|.||.|:|::..||.||||..||...:||.:|..|:..::.|.....:||..||||:|||||:
Human   478 CYCCFWCLDKYLLHLNQNAYTTTAINGTDFCTSAKDAFKILSKNSSHFTSINCFGDFIIFLGKVL 542

  Fly   571 VAALSGLIGIVLLKDKPGLNFYMAPVIIIIIFSFFIAHIILSLFEMVVDTLFLCVCEDKTLNGRS 635
            |...:...|::..........:..|::::..|::.:||..||:||.|:|.||||...|...|..|
Human   543 VVCFTVFGGLMAFNYNRAFQVWAVPLLLVAFFAYLVAHSFLSVFETVLDALFLCFAVDLETNDGS 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ctl1	NP_647884.1	DUF4481	<207..>316	CDD:291466	28/108 (26%)
		Choline_transpo	286..629	CDD:282384	114/346 (33%)
SLC44A3	NP_001107578.1	Choline_transpo	288..601	CDD:282384	114/346 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..653

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149880
Domainoid	1	1.000	268	1.000	Domainoid score	I1871
eggNOG	1	0.900	-	-		E1_KOG1362
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1901
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45602
OrthoDB	1	1.010	-	-		D167290at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41764
orthoMCL	1	0.900	-	-		OOG6_104769
Panther	1	1.100	-	-	O	PTHR12385
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2976
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770