DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1273 and TMPRSS15

DIOPT Version :9

Sequence 1:	NP_647883.1	Gene:	CG1273 / 38522	FlyBaseID:	FBgn0035522	Length:	1168	Species:	Drosophila melanogaster
Sequence 2:	XP_011527956.1	Gene:	TMPRSS15 / 5651	HGNCID:	9490	Length:	1064	Species:	Homo sapiens

Alignment Length:	786	Identity:	147/786 - (18%)
Similarity:	226/786 - (28%)	Gaps:	264/786 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 APSTFSAKTHTQYPKN--RSFSIILTTAAFIVLLTVISIAGLAFYFSSIKTNLEDP-VMGFEGSF 143
            |.:||...:...|..|  ...|:.....||.:...:..|    |..|::|...::. |:.|:.::
Human    58 ARATFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEI----FLSSNLKNEYKNSRVLQFDKNW 118

  Fly   144 RIAKGDLFSTGLKYNHTTTYKQKIDFYKRFVERSMMDNGLQPLRTDVWGFGDGPLIKVSFRVFLD 208
            |.|:.::.||...|:          .|..::.:....||               .|.|.|.:|
Human   119 RQAENEVESTVSLYS----------LYGSWIHQKYQKNG---------------SIIVVFDLF-- 156

  Fly   209 VRKLPQNILSVEEYIKESLF--LETSAAKSLYRSLRLDTESVEIKRIMDEQVVRSAAILKEAQTV 271
               ..|.:  .:|.:||.|.  ||.:.:..|. :..:|..||:|           .|.|:...||
Human   157 ---FAQWV--SDENVKEELIQGLEANKSSQLV-TFHIDLNSVDI-----------LASLENFSTV 204

  Fly   272 PTSQTQLEKRLMKKGSTPATPPVHPKPNPNTTPKPKNPLLRSHSADEEPDIDVENAPVIQGSFEG 336
            ..:.|..:.......:||....:...|..:    |....|....||...|.:| |.|      :|
Human   205 SPATTSDKLTTTSHLATPGNVSIECLPGSS----PCTDALTCIKADLFCDGEV-NCP------DG 258

  Fly   337 SFEITKTDADIARKK---TPPTRAYQAASSTLPPKAIAVTPFSLRVKPK---KPSIEKLTTVLPQ 395
            |.|..|..|.:...:   |..:.::||.....|.:...|..:.:||...   |.|.:...|....
Human   259 SDEDNKMCATVCDGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTD 323

  Fly   396 QLPTGGPISSTRATTKATKATTTTTKRTTTSTTRKTTTTTTPKPTTTTTTTEATTTTTTSTTTTT 460
            .|.....:.|::..            |.:...|...|........|.|...|:..:.......
Human   324 ILDIYEGVGSSKIL------------RASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNA-- 374

  Fly   461 PPLPPSTTRATTTSTNTFTYPSVNTPPPNQGGSLPKLDANL-----FTTFPILDTQPWRPMHREV 520
                              ||.:.|:...|   :..|::.|.     |....:.|...|..:....
Human   375 ------------------TYTAFNSSELN---NYEKINCNFEDGFCFWVQDLNDDNEWERIQGST 418

  Fly   521 PELLPGP--------PPAF--PTKTLPGGTTPTVNHIPQRRIDEFELPFIADNPTPPTAAVAPVT 575
            .....||        ...|  .|.|.|||.        |.|:....||.   :|          |
Human   419 FSPFTGPNFDHTFGNASGFYISTPTGPGGR--------QERVGLLSLPL---DP----------T 462

  Fly   576 VDPYSLGFLNPGLRVQEPKPNLGPQAQDQDMLFYHNFGS-----PIFMPGTENIERL-------- 627
            ::|..|.|                        :||.:|.     .|.:...:|:|:.
Human   463 LEPACLSF------------------------WYHMYGENVHKLSINISNDQNMEKTVFQKEGNY 503

  Fly   628 ---------------------------------------------GGALVEPHPLPVPLIDDVII 647
                                                         |....||..:|.|
Human   504 GDNWNYGQVTLNETVKFKVAFNAFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTP------- 561

  Fly   648 PPFKPIDATMGTGDKMPFNLDASNERFEHLGGGVIAKKPQEKLEKKEQPSKKEQLEAHVKEANQT 712
            ||..|.|.                      ||.....:|.........|:....|...|...|
Human   562 PPELPTDC----------------------GGPFELWEPNTTFSSTNFPNSYPNLAFCVWILN-- 602

  Fly   713 APEKKKAQAHNDQKADQPEITTKVE-RKQEKVEVTTLATNVPVKSSPKPTKSPSLPSLKPT---- 772
            |.:.|..|.| .|:.|...|...|| |..|:.:...||    |.:.|.|.|.....:.:.|
Human   603 AQKGKNIQLH-FQEFDLENINDVVEIRDGEEADSLLLA----VYTGPGPVKDVFSTTNRMTVLLI 662

  Fly   773 DNSVLA 778
            .|.|||
Human   663 TNDVLA 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1273	NP_647883.1	None
TMPRSS15	XP_011527956.1	SEA	53..195	CDD:214554	38/184 (21%)
		LDLa	229..263	CDD:238060	12/44 (27%)
		CUB	270..376	CDD:278839	18/137 (13%)
		MAM	387..547	CDD:214533	28/204 (14%)
		MAM	392..547	CDD:99706	27/199 (14%)
		CUB	569..676	CDD:278839	29/129 (22%)
		LDLa	688..722	CDD:238060
		SR	723..816	CDD:214555
		Tryp_SPc	829..1059	CDD:214473
		Tryp_SPc	830..1061	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGTX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900