DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1273 and Tmprss15

DIOPT Version :9

Sequence 1:	NP_647883.1	Gene:	CG1273 / 38522	FlyBaseID:	FBgn0035522	Length:	1168	Species:	Drosophila melanogaster
Sequence 2:	NP_032967.1	Gene:	Tmprss15 / 19146	MGIID:	1197523	Length:	1069	Species:	Mus musculus

Alignment Length:	1090	Identity:	196/1090 - (17%)
Similarity:	316/1090 - (28%)	Gaps:	458/1090 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 SFSIILTTAAFIVLLTVISIAGLAFYFSSIKTNLEDPVMG----FEGSFRIAKGDLFSTGLKYNH 159
            ||.::|  :|..::|.|.||..:|..:.::|.:..|..:|    ..|:|:|..|..::..|:..|
Mouse    16 SFEVML--SALFIMLMVFSIGLIAVSWLAVKESEGDAALGKSHEVRGTFKITSGVTYNPNLQDKH 78

  Fly   160 TTTYK-------QKIDFYKRFVERSMMDNGLQPLRTDVWGFGDGPLIKVSFRVFLDVRKLPQNIL 217
            :..:|       |.||   ...|.|.:.|..:  ::.|:.|..|.:| |.|.:|.......:|
Mouse    79 SVDFKVLAFDLQQMID---EIFESSSLKNEYE--KSKVFQFEKGSVI-VLFDLFFAQWVSDKN-- 135

  Fly   218 SVEEYIKESLF--LETSAAKSLYRSLRLDTESVEIKRIMDEQVVRSAAILKEAQTVPTSQTQLEK 280
                 :||.|.  :|.:.:..|. :|.:|..|::|...:.:
Mouse   136 -----VKEELIQGIEANISSQLV-TLHIDLNSIDITASLSD------------------------ 170

  Fly   281 RLMKKGSTPATPPVHPKPNPNTTPKPKNPLLRSHSADEEPDIDVENAPVIQGSFEGSFEITKTDA 345
                  .|.|.|                                               :|.:|
Mouse   171 ------FTTAVP-----------------------------------------------VTTSD- 181

  Fly   346 DIARKKTPPTRAYQAASSTLPPKAIAVTPFSLRVKPKKPSIEKLTTVLPQQLPTGGPISSTRATT 410
                                                      ||||..|.             ||
Mouse   182 ------------------------------------------KLTTSSPM-------------TT 191

  Fly   411 KATKATTTTTKRTTTSTTRKTTTTTTPKPTTTTTTTEATTTTTTSTTTTTPPLPPSTTRATTTST 475
            .|:....:||...|||.           |....:|....||:...:....|...|........:|
Mouse   192 SASLGNLSTTVAATTSA-----------PLCNLSTATFATTSGHVSIECQPGSRPCAHAWNCVAT 245

  Fly   476 NTFTYPSVNTPPPNQGGSLPKLDANLFTT-----FPILDTQPWRPMHREVPELLPGPPPAFPTKT 535
            :.|....||.|..:..      |..|..|     |                 ||.|....|....
Mouse   246 DLFCDGEVNCPDGSDE------DTGLCATACDGRF-----------------LLTGDSGVFQADR 287

  Fly   536 LPGGTTPTVNHIPQRRIDEFELPFIADNPTPPTAAVAPVTVDPYSLGFLNPGLRVQEPKPNLGPQ 600
            .|             |.||             :..|....:.      :|.||.::
Mouse   288 YP-------------RPDE-------------SGVVCRWIIR------VNQGLSIR--------- 311

  Fly   601 AQDQDMLFYHNFGSPIFMPGTENI----ERLG------GALVEPHPLPVPLIDDVIIPPF----- 650
                     .||||  |:|...::    |.:|      |:..|..|..:.:..:::...|
Mouse   312 ---------MNFGS--FIPHYTDVLDIYEGIGPSKILRGSFWETDPGTIRIFSNLVTVTFLIKSD 365

  Fly   651 ----------------------KPIDATMGTGDKMPF-----NLDASNE---------------R 673
                                  :.||.|...|    |     :||..||               |
Mouse   366 EYDYIGFNATYSTFNNSELNNYEKIDCTFDDG----FCFWTQDLDDDNEWERIQVTTFPCYTGPR 426

  Fly   674 FEHL---GGGVIAKKPQEK-------------LEKKEQP-----------SKKEQLEAHVKEANQ 711
            |:|.   |.|.....|.|:             |:...:|           .....|..|:..|..
Mouse   427 FDHTYGNGSGFYISTPTEQGWRSERVGLSSLSLDLTSEPVCLHFWYYMCCENVYNLNIHISSAET 491

  Fly   712 TAPEKKKAQAHNDQKADQPEITTKVERKQEKV--------EVTTLA------TNVPVKSS--PKP 760
            |.....:.:.:..:..:..::|.. |..:.||        ..:|:|      ||.....|  |:|
Mouse   492 TDKIVFQRKGNYGRNWNYGQVTLN-ETGEFKVVFNAFRNRGCSTIALDDISLTNGICSQSPYPEP 555

  Fly   761 TKSPSLPSLKPTDNSVLADTIGEFFMELLNLPKEENATATKKPIEDAIESRIEPEEEE---SLDT 822
            |..|:.|...|||..      |.|  ||.    |.|:|.:.....|..     |.:..   :|:.
Mouse   556 TLVPTPPPELPTDCG------GPF--ELW----EPNSTFSSPNFPDKY-----PNQASCIWNLNA 603

  Fly   823 LKAPSVSLSKPNF--MNLKEIILQRN---TPSSILSNET----LEESTTTTMPTTTTRTTTEEPR 878
            .:..::.|....|  .|:.:::..|:   ..|.:|:..|    :::..:||...|...||..|.|
Mouse   604 QRGKNIQLHFQEFDLENINDVVEVRDGGEFDSLLLAVYTGPGPVKDLFSTTNRMTVIFTTNMETR 668

  Fly   879 TTKRNRIRTTS------ERPTMMD-----DSNLFP----------------SHSKWEFVNSSSAQ 916
             .|..:...||      ..|...|     |.|..|                ..|...|:|.:.:.
Mouse   669 -RKGFKANFTSGYYLGIPEPCQDDEFQCKDGNCIPLGNLCDSYPHCRDGSDEASCVRFLNGTRSN 732

  Fly   917 GFGHNSNMRKVF------NQTLQAWVSEDIDK-----SENLTLNDIKT------RINNASNIQDI 964
            ......|:..::      |.|.|  :|.::..     |.|.::....|      |:|.|.|
Mouse   733 NGLVQFNIHSIWHIACAENWTTQ--ISNEVCHLLGLGSANSSMPISSTGGGPFVRVNQAPN---- 791

  Fly   965 SLIFDTLASKLGITPSVPNKFPPFSQNKL-------KHAPKEEVTRRPIP 1007
                    ..|.:|||:     ..||:.|       |...:::||::..|
Mouse   792 --------GSLILTPSL-----QCSQDSLILLQCNHKSCGEKKVTQKVSP 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1273	NP_647883.1	None
Tmprss15	NP_032967.1	SEA	53..154	CDD:214554	27/114 (24%)
		LDLa	228..261	CDD:197566	7/32 (22%)
		CUB	270..376	CDD:294042	25/174 (14%)
		MAM	392..549	CDD:279023	28/161 (17%)
		MAM	392..547	CDD:99706	28/159 (18%)
		CUB	569..676	CDD:278839	25/124 (20%)
		LDLa	688..722	CDD:238060	4/33 (12%)
		SR	723..816	CDD:214555	21/111 (19%)
		SRCR	728..819	CDD:278931	20/109 (18%)
		Tryp_SPc	829..1064	CDD:214473	196/1090 (18%)
		Tryp_SPc	830..1066	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGTX
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900