DRSC/TRiP Functional Genomics Resources

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Protein Alignment KRT5 and BIK1

DIOPT Version :10

Sequence 1:NP_000415.2 Gene:KRT5 / 3852 HGNCID:6442 Length:590 Species:Homo sapiens
Sequence 2:NP_009901.1 Gene:BIK1 / 850328 SGDID:S000000534 Length:440 Species:Saccharomyces cerevisiae


Alignment Length:362 Identity:75/362 - (20%)
Similarity:135/362 - (37%) Gaps:113/362 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   140 IQEVTVNQ----SLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFID-----KVRFLEQQNKV 195
            |::.:::|    :.:.||::..:.||.|           |.|:|:...|     .:|.....::.
Yeast    77 IEKASISQTSRRTTMEPLSIPKNRSIVR-----------LTNQFSPMDDPKSPTPMRSFRITSRH 130

Human   196 LDTKWTLLQEQGTKTVRQNLEPLFEQYINNL-RRQLDSIV------------------GERGRLD 241
            ...:.::.||......:|..     .|.|.. |.::|||:                  |....|:
Yeast   131 SGNQQSMDQEASDHHQQQEF-----GYDNREDRMEVDSILSSDRKANHNTTSDWKPDNGHMNDLN 190

Human   242 S-----ELRNMQDLVEDFKNK------------------------YEDEINKRTTAENEFVMLKK 277
            |     |||..|..:|..:.|                        ||..|.:|   |.|...||:
Yeast   191 SSEVTIELREAQLTIEKLQRKQLHYKRLLDDQRMVLEEVQPTFDRYEATIQER---EKEIDHLKQ 252

Human   278 DVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLD------LD 336
                    ::|||.:..|.      .|.|||||..|:...||.....:..:..|||.      .:
Yeast   253 --------QLELERRQQAK------QKQFFDAENEQLLAVVSQLHEEIKENEERNLSHNQPTGAN 303

Human   337 SIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEID 401
            ..:..:|.|.|::  |:..:....::||:.:.::....|.|.|          ::..|.|..|:.
Yeast   304 EDVELLKKQLEQL--RNIEDQFELHKTKWAKEREQLKMHNDSL----------SKEYQNLSKELF 356

Human   402 NVKKQCANLQNAIADAEQRGELALKDARNKLAELEEA 438
            ..|.|.::.:. :|...::    |::|..|:.:||:|
Yeast   357 LTKPQDSSSEE-VASLTKK----LEEANEKIKQLEQA 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT5NP_000415.2 Head 1..167 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Keratin_2_head 16..164 CDD:465068 6/27 (22%)
Filament 167..480 CDD:459643 68/331 (21%)
Coil 1A 168..203 5/39 (13%)
Linker 1 204..222 3/17 (18%)
Coil 1B 223..315 33/139 (24%)
Linker 12 316..338 5/27 (19%)
Coil 2 339..477 21/100 (21%)
Tail 478..590
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 566..590
BIK1NP_009901.1 CAP_GLY 8..73 CDD:460154
SMC_prok_B 193..>395 CDD:274008 51/230 (22%)
Blue background indicates that the domain is not in the aligned region.

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