Protein Alignment KRT5 and krt5

DIOPT Version :10

• Sequence 1: NP_000415.2
• Gene: KRT5 / 3852
• HGNCID: 6442
• Length: 590
• Species: Homo sapiens
• Sequence 2: NP_571231.2
• Gene: krt5 / 797351
• ZFINID: ZDB-GENE-991110-23
• Length: 566
• Species: Danio rerio
• Alignment Length: 608
• Identity: 350/608 - (57%)
• Similarity: 429/608 - (70%)
• Gaps: 68/608 - (11%)

Human     6 SVSFR--------SGG---------SRSFSTAS-AITPSVSRTSFTSVSRSGGGGGGGFGRVSLA 52
            |.||:        |||         .::||:.| :..|..||:|.:.....|||||||||
Zfish     2 STSFKTFTSSGSMSGGMGGGMGGGIRKNFSSMSTSAVPMGSRSSVSFRRSGGGGGGGGFG----- 61

Human    53 GACGVGGYGSRSLYNLGGSKRISISTSGGSFRNRFGAGAGGGYGFGGGAGSGFGFGGGA--GGGF 115
              .|.||..|   |::||.       .||.     |:|.|||:|.|||.|||.||||||  |||.
Zfish    62 --AGSGGSFS---YSMGGG-------GGGG-----GSGFGGGFGSGGGFGSGGGFGGGAGFGGGS 109

Human   116 GLGGGAGFGGGFGGPGFPVCPPGG---IQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNN 177
            ..|||||||||||        |||   |..|||||:||.||||:|||:||.|||:|:||||||||
Zfish   110 AYGGGAGFGGGFG--------PGGVVPITAVTVNQNLLAPLNLEIDPNIQVVRTQEKEQIKTLNN 166

Human   178 KFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDS 242
            :||||||||||||||||||:|||:|||||  .|.|.|::.:||.||.|||||||.:..|:.:|:.
Zfish   167 RFASFIDKVRFLEQQNKVLETKWSLLQEQ--TTTRSNIDAMFEAYIANLRRQLDGLGNEKMKLEG 229

Human   243 ELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFF 307
            ||:|||:||||||||||||||||...|||||:||||||||||||||||||||:|.|||||::..|
Zfish   230 ELKNMQNLVEDFKNKYEDEINKRAAVENEFVLLKKDVDAAYMNKVELEAKVDSLQDEINFLRAIF 294

Human   308 DAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTA 372
            :.||.::|:.:.|||||:.|||:||||:|:|:|||:||||:||||||.||||||:.|:||:|.:|
Zfish   295 EEELRELQSQIKDTSVVVEMDNSRNLDMDAIVAEVRAQYEDIANRSRAEAESWYKQKFEEMQSSA 359

Human   373 GRHGDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEE 437
            |::||||||||.||:::||||.||:.||:.||.|.|||:..||:||:|||||:|||:.::.:||:
Zfish   360 GKYGDDLRNTKAEIADLNRMISRLQNEIEAVKGQRANLEAQIAEAEERGELAVKDAKLRIKDLED 424

Human   438 ALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRL-SGEGVGPVNISVVTSSVSSG 501
            |||:|||||||.:||||||||.|||||:|||||||||||||.|: ||.....::|. .:||.|.|
Zfish   425 ALQRAKQDMARQVREYQELMNVKLALDIEIATYRKLLEGEESRIASGGNTATIHIQ-ESSSSSGG 488

Human   502 YGSGSGYGGGLGGGLGGGLGGGLAGGSSGSYYSSSSG-GVGLGGGLSVGGSGFSASSGRGLGVGF 565
            .|.|.|||||.|.|.|.|.||| :|...||.:...|| |.|.|.|:|:||         |.|:..
Zfish   489 GGGGFGYGGGSGYGGGSGFGGG-SGYGGGSGFGGGSGFGYGGGSGMSIGG---------GSGMSM 543

Human   566 GSGGGSSSSVKFVSTTSSSRKSF 588
            ..|||...|:...|..||.::.|
Zfish   544 SGGGGGQISMSRSSIVSSQKRRF 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT5	NP_000415.2	Head	1..167		85/183 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		8/30 (27%)
		Keratin_2_head	16..164	CDD:465068	77/153 (50%)
		Filament	167..480	CDD:459643	220/312 (71%)
		Coil 1A	168..203		30/34 (88%)
		Linker 1	204..222		8/17 (47%)
		Coil 1B	223..315		65/91 (71%)
		Linker 12	316..338		13/21 (62%)
		Coil 2	339..477		96/137 (70%)
		Tail	478..590		45/113 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	566..590		8/23 (35%)
krt5	NP_571231.2	Keratin_2_head	<129..153	CDD:465068	17/23 (74%)
		Filament	156..467	CDD:459643	220/312 (71%)