Protein Alignment KRT5 and krt61

DIOPT Version :10

• Sequence 1: NP_000415.2
• Gene: KRT5 / 3852
• HGNCID: 6442
• Length: 590
• Species: Homo sapiens
• Sequence 2: NP_001072377.1
• Gene: krt61 / 779830
• XenbaseID: XB-GENE-876246
• Length: 565
• Species: Xenopus tropicalis
• Alignment Length: 600
• Identity: 402/600 - (67%)
• Similarity: 466/600 - (77%)
• Gaps: 52/600 - (8%)

Human     1 MSRQSSVSFRSGGSRSFSTASAITPSVSRTSFT--SVSRSGGGGGGGFGRVSLAGACGVGGYGSR 63
            :|||:..|  :||::.||.:||:....:|:||:  ||||:||||    ||.|..   |.||:|||
 Frog     3 VSRQTVYS--TGGTKRFSASSAVPSGGTRSSFSTLSVSRAGGGG----GRASYG---GYGGFGSR 58

Human    64 SLYNLGGSKRISISTSGGSFRNRFGAGAGGGYGFGGGAGSGFGFGGGA-----GGGFG--LGGGA 121
            ||.|.|||:||::|.                     ||.|.|||....     ||.:|  :..|.
 Frog    59 SLQNAGGSRRIAVSY---------------------GAPSHFGFKSSGIESHIGGNYGSDMMSGI 102

Human   122 GFG-GGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDK 185
            |.| |.|||||||||||||||||||||:||.||||:|||||||:|||||||||||||||||||||
 Frog   103 GMGQGPFGGPGFPVCPPGGIQEVTVNQTLLAPLNLEIDPSIQRIRTEEREQIKTLNNKFASFIDK 167

Human   186 VRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDL 250
            |||||||||||:|||.||||||.|:|:.|::||||.||:.|||||||::.|:.||||:||.|||.
 Frog   168 VRFLEQQNKVLETKWNLLQEQGVKSVKCNIDPLFEAYISALRRQLDSLLSEKVRLDSDLRQMQDA 232

Human   251 VEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQ 315
            |||:|.||||||||||:.|||||:||||||||||||||||||::||.|||||::..::||::|||
 Frog   233 VEDYKKKYEDEINKRTSVENEFVVLKKDVDAAYMNKVELEAKLNALTDEINFLRAVYEAEIAQMQ 297

Human   316 THVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLR 380
            |.:|||||||||||||.|||:.||||||||||:||||||.|||||||||||||||:|||||||||
 Frog   298 TQISDTSVVLSMDNNRTLDLNGIIAEVKAQYEDIANRSRAEAESWYQTKYEELQQSAGRHGDDLR 362

Human   381 NTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQD 445
            :||.||||:||||.|||:|||:||||||.||.||.:||:|||||||||:.|||:|||||||.||:
 Frog   363 STKTEISELNRMINRLRSEIDSVKKQCAKLQAAITEAEERGELALKDAKKKLADLEEALQKCKQE 427

Human   446 MARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVSSGYGSGSGYGG 510
            |||.|||||||||.||:|||||||||||||||||||:||||||||||||:||...|.|||||||.
 Frog   428 MARQLREYQELMNVKLSLDVEIATYRKLLEGEECRLAGEGVGPVNISVVSSSYGGGSGSGSGYGM 492

Human   511 GLGGGLGGGLGGGLAGGSSGSYYSSSSGGVGLGGGL---SVGGSGFSASSGRGLGVGFGSGGGSS 572
            |.|.|.|||.|.|     :||.| :..||...|||.   .:||:.||.|||:  ...||.|.|||
 Frog   493 GGGSGFGGGSGFG-----AGSGY-AIGGGQSFGGGSVSGGMGGASFSVSSGK--MAAFGPGSGSS 549

Human   573 SSVKFVSTTS-SSRK 586
            |:||.:|.|| ||||
 Frog   550 SNVKIISKTSTSSRK 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT5	NP_000415.2	Head	1..167		87/175 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		8/18 (44%)
		Keratin_2_head	16..164	CDD:465068	79/157 (50%)
		Filament	167..480	CDD:459643	250/312 (80%)
		Coil 1A	168..203		32/34 (94%)
		Linker 1	204..222		11/17 (65%)
		Coil 1B	223..315		65/91 (71%)
		Linker 12	316..338		17/21 (81%)
		Coil 2	339..477		115/137 (84%)
		Tail	478..590		64/112 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	566..590		14/21 (67%)
krt61	NP_001072377.1	Keratin_2_head	17..146	CDD:465068	79/156 (51%)
		Filament	149..462	CDD:459643	250/312 (80%)