Protein Alignment KRT5 and Krt5

DIOPT Version :10

• Sequence 1: NP_000415.2
• Gene: KRT5 / 3852
• HGNCID: 6442
• Length: 590
• Species: Homo sapiens
• Sequence 2: NP_899162.2
• Gene: Krt5 / 369017
• RGDID: 727894
• Length: 576
• Species: Rattus norvegicus
• Alignment Length: 596
• Identity: 523/596 - (87%)
• Similarity: 549/596 - (92%)
• Gaps: 26/596 - (4%)

Human     1 MSRQSSVSFRSGGSRSFSTASAITPSVSRTSFTSVSRSGGGGGGGFGRVSLAGACGVGGYGSRSL 65
            ||||||||||||||||||.|||||||||||:|:|||||||||    |||||.||.|.||||||||
  Rat     1 MSRQSSVSFRSGGSRSFSAASAITPSVSRTTFSSVSRSGGGG----GRVSLGGAYGAGGYGSRSL 61

Human    66 YNLGGSKRISISTSGGSFRNRFGAGAGGGYGFGGGAGSGFGFGGGAGGGFGLGGGAGFGGGFGGP 130
            ||:|||||||.|:.||||||:||||||||||||||||||||||||||.|||.|||||||||:||.
  Rat    62 YNVGGSKRISFSSGGGSFRNQFGAGAGGGYGFGGGAGSGFGFGGGAGSGFGFGGGAGFGGGYGGA 126

Human   131 GFPVCPPGGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKV 195
            |||||||||||||||||:|||||||||||:|||||||||||||||||||||||||||||||||||
  Rat   127 GFPVCPPGGIQEVTVNQNLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKV 191

Human   196 LDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYED 260
            |||||||||||||||::|||:|||||||||||||||.::|||||||||||||||||||:||||||
  Rat   192 LDTKWTLLQEQGTKTIKQNLDPLFEQYINNLRRQLDGVMGERGRLDSELRNMQDLVEDYKNKYED 256

Human   261 EINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVL 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   257 EINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVL 321

Human   326 SMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMN 390
            ||||||:|||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
  Rat   322 SMDNNRSLDLDSIIAEVKAQYEDIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMN 386

Human   391 RMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQDMARLLREYQE 455
            |||||||:|||||||||||||||||:||||||||||||||||.||||||||||||||||||||||
  Rat   387 RMIQRLRSEIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEALQKAKQDMARLLREYQE 451

Human   456 LMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVSSGYG--SGSGYGGGLGGGLGG 518
            ||||||||||||||||||||||||||||||||||||||||:|:|||||  |..|||.|||.|:||
  Rat   452 LMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTNSLSSGYGGRSNIGYGSGLGSGIGG 516

Human   519 GLGGGLAGGSSGSYYSSSSGGV----GLGGGLSVGGSGFSASSGRGLGVGFGSGGGSSSSVKFVS 579
                          ::|..|.:    |||.||||||||||||||:  |.||.|||||||||||||
  Rat   517 --------------FASDIGPLLNRRGLGSGLSVGGSGFSASSGQ--GGGFSSGGGSSSSVKFVS 565

Human   580 TTSSSRKSFKS 590
            ||||||:||||
  Rat   566 TTSSSRRSFKS 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KRT5	NP_000415.2	Head	1..167		144/165 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		18/18 (100%)
		Keratin_2_head	16..164	CDD:465068	126/147 (86%)
		Filament	167..480	CDD:459643	300/312 (96%)
		Coil 1A	168..203		34/34 (100%)
		Linker 1	204..222		14/17 (82%)
		Coil 1B	223..315		87/91 (96%)
		Linker 12	316..338		20/21 (95%)
		Coil 2	339..477		133/137 (97%)
		Tail	478..590		77/117 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	566..590		21/23 (91%)
Krt5	NP_899162.2	Head. /evidence=ECO:0000255	1..163		144/165 (87%)
		Keratin_2_head	16..160	CDD:465068	126/147 (86%)
		Filament	163..476	CDD:459643	300/312 (96%)
		Coil 1A. /evidence=ECO:0000255	164..199		34/34 (100%)
		Linker 1. /evidence=ECO:0000255	200..218		14/17 (82%)
		Coil 1B. /evidence=ECO:0000255	219..311		87/91 (96%)
		Linker 12. /evidence=ECO:0000255	312..334		20/21 (95%)
		Coil 2. /evidence=ECO:0000255	335..473		133/137 (97%)
		Tail. /evidence=ECO:0000255	474..576		77/117 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	540..576		31/37 (84%)