DRSC/TRiP Functional Genomics Resources

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Protein Alignment KRT5 and LamC

DIOPT Version :10

Sequence 1:NP_000415.2 Gene:KRT5 / 3852 HGNCID:6442 Length:590 Species:Homo sapiens
Sequence 2:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster


Alignment Length:415 Identity:110/415 - (26%)
Similarity:189/415 - (45%) Gaps:56/415 - (13%)


- Green bases have known domain annotations that are detailed below.


Human   165 RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQ---NLEPLFEQYINNL 226
            |.:|:|:::.||::.|.:||::|.||.:|..|..:..|.|:    ||.:   ||:.::|:.:...
  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD----TVNRETSNLKAVYEKELAAA 103

Human   227 RRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAEN--------------------- 270
            |:.||....|:.:|:.:::.:.:..:|.|.:.:.:..:.|.|||                     
  Fly   104 RKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLA 168

Human   271 ----------EFVM-----------LKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAEL--- 311
                      |..:           |:|.::|..:.:|:||.:..:|.:|:.|.......||   
  Fly   169 DRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTET 233

Human   312 -SQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRH 375
             |:.|..:|:....||  ......|...:.|::.|||.....:|.|.|..|..:.:.|:..|.|.
  Fly   234 RSRRQIEISEIDGRLS--RQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRA 296

Human   376 GDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQ 440
            .........|:..|...|..|.|::.|::...|.|...|.:.|...:...:.....:|.||..||
  Fly   297 AQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQ 361

Human   441 KAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVG-PVNISVVTSSVSSGYGS 504
            :.:.:||..|:|||.||:.|::||:|||.|.|||.|||.||:.|..| |...|.::|:.|....|
  Fly   362 RMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTAS 426

Human   505 GSGYGGGLGGGLGGGLGGGLAGGSS 529
            .|...|.:..........|::|.|:
  Fly   427 ASSRSGRVTPSGRRSATPGISGSSA 451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT5NP_000415.2 Head 1..167 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Keratin_2_head 16..164 CDD:465068
Filament 167..480 CDD:459643 95/361 (26%)
Coil 1A 168..203 12/34 (35%)
Linker 1 204..222 6/20 (30%)
Coil 1B 223..315 24/137 (18%)
Linker 12 316..338 4/21 (19%)
Coil 2 339..477 44/137 (32%)
Tail 478..590 15/53 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 566..590
LamCNP_001260974.1 Filament 45..401 CDD:459643 95/361 (26%)
PRK13922 154..>221 CDD:473155 9/66 (14%)
LTD 474..574 CDD:460003
Blue background indicates that the domain is not in the aligned region.

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