DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KRT5 and LamC

DIOPT Version :9

Sequence 1:NP_000415.2 Gene:KRT5 / 3852 HGNCID:6442 Length:590 Species:Homo sapiens
Sequence 2:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster


Alignment Length:415 Identity:110/415 - (26%)
Similarity:189/415 - (45%) Gaps:56/415 - (13%)


- Green bases have known domain annotations that are detailed below.


Human   165 RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQ---NLEPLFEQYINNL 226
            |.:|:|:::.||::.|.:||::|.||.:|..|..:..|.|:    ||.:   ||:.::|:.:...
  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD----TVNRETSNLKAVYEKELAAA 103

Human   227 RRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAEN--------------------- 270
            |:.||....|:.:|:.:::.:.:..:|.|.:.:.:..:.|.|||                     
  Fly   104 RKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLA 168

Human   271 ----------EFVM-----------LKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAEL--- 311
                      |..:           |:|.::|..:.:|:||.:..:|.:|:.|.......||   
  Fly   169 DRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTET 233

Human   312 -SQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRH 375
             |:.|..:|:....||  ......|...:.|::.|||.....:|.|.|..|..:.:.|:..|.|.
  Fly   234 RSRRQIEISEIDGRLS--RQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRA 296

Human   376 GDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQ 440
            .........|:..|...|..|.|::.|::...|.|...|.:.|...:...:.....:|.||..||
  Fly   297 AQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQ 361

Human   441 KAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVG-PVNISVVTSSVSSGYGS 504
            :.:.:||..|:|||.||:.|::||:|||.|.|||.|||.||:.|..| |...|.::|:.|....|
  Fly   362 RMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTAS 426

Human   505 GSGYGGGLGGGLGGGLGGGLAGGSS 529
            .|...|.:..........|::|.|:
  Fly   427 ASSRSGRVTPSGRRSATPGISGSSA 451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT5NP_000415.2 Head 1..167 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Keratin_2_head 16..164 CDD:292825
Filament 167..480 CDD:278467 95/361 (26%)
Coil 1A 168..203 12/34 (35%)
Linker 1 204..222 6/20 (30%)
Coil 1B 223..315 24/137 (18%)
Linker 12 316..338 4/21 (19%)
Coil 2 339..477 44/137 (32%)
DUF883 393..>453 CDD:295076 16/59 (27%)
Tail 478..590 15/53 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 566..590
LamCNP_001260974.1 Filament 45..401 CDD:278467 95/361 (26%)
ATP-synt_B <67..>142 CDD:304375 18/78 (23%)
MreC <178..>224 CDD:302802 10/45 (22%)
LTD 473..574 CDD:279300
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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