DRSC/TRiP Functional Genomics Resources

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Protein Alignment KRT5 and Lam

DIOPT Version :10

Sequence 1:NP_000415.2 Gene:KRT5 / 3852 HGNCID:6442 Length:590 Species:Homo sapiens
Sequence 2:NP_476616.1 Gene:Lam / 33782 FlyBaseID:FBgn0002525 Length:622 Species:Drosophila melanogaster


Alignment Length:426 Identity:113/426 - (26%)
Similarity:205/426 - (48%) Gaps:87/426 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   129 GPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQN 193
            ||..|  ||.     |.:|:..:||:    |: :..|..|:.:::.||::.|::||:||.||.:|
  Fly    27 GPQPP--PPS-----THSQTASSPLS----PT-RHSRVAEKVELQNLNDRLATYIDRVRNLETEN 79

Human   194 -----KVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVED 253
                 :|..|:.|:.:|      ..|::.:||..:...||.||....:|.|.:.:::.:.:..|:
  Fly    80 SRLTIEVQTTRDTVTRE------TTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWEENEE 138

Human   254 FKNKYEDEINKRTTAE------------------------------------------NEFVMLK 276
            .|||.:.:..:.||||                                          .:|...:
  Fly   139 LKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQANADRKKLNEDLNEALKELERLRKQFEETR 203

Human   277 KDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQ----MQTHVSDTSVVLSMDNNRNLDLDS 337
            |:::...:::|:||..:.:|.:|::|.......|:::    .||..|:....||.:.:..  |..
  Fly   204 KNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINESRRIKQTEYSEIDGRLSSEYDAK--LKQ 266

Human   338 IIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDN 402
            .:.|::|||||....:|.|.:|.|:.|.:.||:.|.|..:....:..|:......|..|.|.|:.
  Fly   267 SLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEAAARTSNSTHKSIEELRSTRVRIDALNANINE 331

Human   403 VKKQCANLQNAIADAEQRGELALKDARNKLAE----LEEALQKAKQDMARLLREYQELMNTKLAL 463
            :::..|:|...|.|.|::    |.:.|.:..:    ||:.|.:.:::|.:.|:|||:||:.|::|
  Fly   332 LEQANADLNARIRDLERQ----LDNDRERHGQEIDLLEKELIRLREEMTQQLKEYQDLMDIKVSL 392

Human   464 DVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVS 499
            |:|||.|.|||.|||.||        ||:..|::.:
  Fly   393 DLEIAAYDKLLVGEEARL--------NITPATNTAT 420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KRT5NP_000415.2 Head 1..167 11/37 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Keratin_2_head 16..164 CDD:465068 10/34 (29%)
Filament 167..480 CDD:459643 97/367 (26%)
Coil 1A 168..203 14/39 (36%)
Linker 1 204..222 4/17 (24%)
Coil 1B 223..315 23/137 (17%)
Linker 12 316..338 5/21 (24%)
Coil 2 339..477 47/141 (33%)
Tail 478..590 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 566..590
LamNP_476616.1 Filament 54..409 CDD:459643 97/366 (27%)
LTD 467..572 CDD:460003
Blue background indicates that the domain is not in the aligned region.

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