DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1309 and ABHD16A

DIOPT Version :9

Sequence 1:	NP_647880.1	Gene:	CG1309 / 38519	FlyBaseID:	FBgn0035519	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_066983.1	Gene:	ABHD16A / 7920	HGNCID:	13921	Length:	558	Species:	Homo sapiens

Alignment Length:	560	Identity:	233/560 - (41%)
Similarity:	323/560 - (57%)	Gaps:	54/560 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LNYVFGPNLYMEYR---------GVPEPQRKM-----------YEAGAVEKFGEQILSTLSVMWS 48
            |:.|.||.||..||         .|||....:           |:..|:||..:.||:..||.||
Human     5 LSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWS 69

  Fly    49 VGYYTSPLLVTFLYRRGYLVTDSIPTLAKITTSVGLIVILSLVMRGLGR---KQSRSYSNMIKAL 110
            :.||:||....:|||:|||....:...:....::.|::.....:||:||   .|.|.:..:::|.
Human    70 ISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEAT 134

  Fly   111 VRAKSSKAPGDANSELRRFDIEFNAWPVDF------DVKALTGDTKKPVVTARRREPIQLAT--- 166
            .|.:||    :...:|..::.:|.:|||||      ..|...|...:..|...|.||:...|
Human   135 HRNQSS----ENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADT 195

  Fly   167 -------LPCEAIAYLAINTFGLSMIYPGSVKLLQKLMRPMLISGRAKLIEDDNGIRYKVKTIDS 224
                   |||:..:||..:|.|..|:|||||.||||.:.|:|:.|:|:|:|:.||.|.|:...|.
Human   196 LLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDG 260

  Fly   225 NEIDTLFIDNRPNNVGNGKTLVICSEGNAGFYEVGIMATPVALKYSVLGWNHPGFAGSTGTPHPH 289
            |||||:|:|.|......|:.||||.||||||||||.::||:...||||||||||||||||.|.|.
Human   261 NEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQ 325

  Fly   290 QDKNAIDAVVQFAINNLRFPVEDIILYGWSIGGFSTLYAASVYPDVKGVVLDATFDDVLYLAVPR 354
            .:.||:|.||||||:.|.|..:|||:|.||||||:..:||..||||..::|||:|||::.||:..
Human   326 NEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDVSAMILDASFDDLVPLALKV 390

  Fly   355 MPAALAGIVKVAIRNYCNLNNAELANEFNGPISFIRRTEDEIIA----EDNHIDTNRGNFLVLSV 415
            ||.:..|:|...:|.:.||||||....:.||:..||||:||||.    ||  |.:||||.|:|.:
Human   391 MPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPED--IMSNRGNDLLLKL 453

  Fly   416 LKHRYPNIFGASQLNKAKGLL--SKPLEP---YSIPVADEKLCMSRLITYASDEGKSFPMNIGAD 475
            |:||||.:.....|...:..|  |..||.   ||....:|..|:|.|.:|.::.|..||.::|.|
Human   454 LQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGED 518

  Fly   476 YSEEVRNLMAVFLLRKHLRDYNSTHCTQLPGEFFTMPWDI 515
            .|.:.|..:|:||.||||.::.:||||.||.:.|.|||.:
Human   519 MSADGRRQLALFLARKHLHNFEATHCTPLPAQNFQMPWHL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1309	NP_647880.1	Abhydrolase_5	245..>356	CDD:289465	69/110 (63%)
ABHD16A	NP_066983.1	Abhydrolase_1	280..>408	CDD:366166	74/127 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158519
Domainoid	1	1.000	146	1.000	Domainoid score	I4564
eggNOG	1	0.900	-	-		E1_KOG1553
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10904
Inparanoid	1	1.050	412	1.000	Inparanoid score	I1861
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45526
OrthoDB	1	1.010	-	-		D264054at33208
OrthoFinder	1	1.000	-	-		FOG0004914
OrthoInspector	1	1.000	-	-		otm42159
orthoMCL	1	0.900	-	-		OOG6_106577
Panther	1	1.100	-	-	LDO	PTHR12277
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2935
SonicParanoid	1	1.000	-	-		X3467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800