DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15011 and FAP1

DIOPT Version :9

Sequence 1:	NP_647879.1	Gene:	CG15011 / 38518	FlyBaseID:	FBgn0035518	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_014375.1	Gene:	FAP1 / 855708	SGDID:	S000004968	Length:	965	Species:	Saccharomyces cerevisiae

Alignment Length:	861	Identity:	223/861 - (25%)
Similarity:	325/861 - (37%)	Gaps:	287/861 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 YKNYKPSDNAGSSKEAA--RTSTFLENT-------------LHSG-AATCLICIGSIRRVEAIWS 90
            |:::..||...||.|.|  :.|::.|.:             :.|| :..|:||...:.....:::
Yeast    19 YRHHNLSDGCISSVEDANEQPSSYEEESDDDMQYYERAIQEISSGDSYVCMICTVEMDYTCQMFA 83

  Fly    91 CESCYCFFHLKCIQRWANDSMMQMKVKAAEQQNGQGHYNHLGEFVPPKRQKSLH--WCCPKC--- 150
            |:.||..|...||:.||        :|:.|                    |::.  |.||.|
Yeast    84 CKRCYRVFDYGCIREWA--------LKSTE--------------------KTVDRIWKCPNCYYV 120

  Fly   151 RRDYQPADKPTQYNCFCGKEVNPENQPFLVPHSCGEHCGKLLQPKCGHDCKLLCHPGPCPPCAQQ 215
            .:.....::||   |:|||.|||:..| |.|:|||:.|.   ...|.|.|..:||.||.|.|.:.
Yeast   121 SKRVPVKNRPT---CWCGKVVNPDPNP-LDPNSCGQTCN---ASTCMHGCSKICHLGPHPECTRM 178

  Fly   216 AQVSCLCGKSSPRSVRC-----IDKQWTCQQTCKELLACGKHKCNQVCHQPGKCPPC-------- 267
            .::.|.|||.| :|:.|     :.|.:.||:.|...|:|..|.|.:.|| ||.|.||
Yeast   179 VEIMCHCGKHS-KSIFCYQSKVMKKNFNCQEVCGLPLSCSIHTCKKKCH-PGLCGPCPEMIISKD 241

  Fly   268 TSKSLQPCECQRESKM-VNCSDRKW-------KCQN--------VCG----APFACGLHICEKVC 312
            :.|....|.|...::. :.||:.|:       |.:|        .|.    ..::|..|...:.|
Yeast   242 SPKKQIKCYCGNHTRANIKCSETKFPKSGKSSKDENGNRWIGVFACADNRVVDYSCRKHSFIESC 306

  Fly   313 HAGPCGDGE--CPL---QVRSCPCGKN-----TQVRP-CNETEETCGDTCQKLLSCGQHTCTQRC 366
            .:.|..:||  ||.   .:::||||:.     |:.|. |::...||...|.|.|.||:|:|...|
Yeast   307 ISPPTINGEKACPFLPSSLKTCPCGRTALEELTKPRKHCDDPIPTCDSRCGKPLKCGKHSCPFTC 371

  Fly   367 HRGPCIS-CPIRTKKKCRCGLHEKELPCSKEF--ACETKCKQMRDCGKHACNRKCCGDQCPP--- 425
            |...|:. |......||.|......:||..:.  .|..||:.:..|.:|.|..:||..: |.
Yeast   372 HDKACMEPCLQIDSVKCACEQSTFSVPCGFQGRPRCNIKCESLMSCRRHRCTDRCCSGR-PSAIR 435

  Fly   426 ----------------------CEKICGKQLSCNKHKCQSVCHNGPCYPCKLESQIN---CRCGK 465
                                  |.|.|...|||..||||..||.|.|.|| |||..|   |.||.
Yeast   436 RKKNLFRTQDLLDESLVEAKHICLKPCNLTLSCGIHKCQRKCHPGKCPPC-LESDSNDLVCPCGN 499

  Fly   466 TKKSVP--CGRE-RSARIVCLELCRITPKC-HHAIKHRCHKGD--CPPCGQVCGLPNDTSKCGHI 524
            |....|  ||.: .:....|:::.|....| |..:.|.||..|  ||||.:....|   .|||..
Yeast   500 TVVPAPVRCGTKLPTCNHPCIKVVRGESTCGHKPMPHTCHSLDVSCPPCTETVFKP---CKCGKK 561

  Fly   525 CKARCHEAVRVNKPKEARPQAKKYEYKALPHPRCEEGVIVTCIGGHEVATWPCWNSKPTSCQR-- 587
            .|.|                                                      |.|.:
Yeast   562 TKVR------------------------------------------------------TVCFQTD 572

  Fly   588 -SCARQLKCGNHKCSLVCHFVPLPQDMSAQTGCANCEEGCTVPRPTGCIHACPKGCHPPPCAPCN 651
             ||.  :|||          :||                      :.|.|.|.|.||.|
Yeast   573 VSCG--IKCG----------IPL----------------------SYCYHTCQKTCHLP------ 597

  Fly   652 FVIKTKCHCGLNQLVYKCNEYYDETGSVQEIIERREKLRSCGNRCLKNYPCGHRCTAICHTGKCP 716
                                     |:.|::.:     ::||.:.|.   |.|.|...|| ||..
Yeast   598 -------------------------GNCQKVCK-----QTCGQKRLN---CNHECPKPCH-GKTE 628

  Fly   717 NPEL-CRKKVRIFCACKRLKQEIAC--DKHRAGQT---FLDCDSNCKAEQIRVQAAEQLQLEQKR 775
            .|:| |...|:|:|.|.|:|:.:.|  ...|...|   .|||:..|:|.: |::     :|::..
Yeast   629 CPDLPCATLVKIYCKCGRIKKSVTCGAKSDRVSVTESSVLDCNEECEALK-RLK-----ELKEAF 687

  Fly   776 RDEEERNRLELEKFEA 791
            ..:||.|.....:.:|
Yeast   688 GIKEETNNFTSNELDA 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15011	NP_647879.1	NF-X1-zinc-finger	184..228	CDD:100116	17/43 (40%)
		NF-X1-zinc-finger	239..288	CDD:100116	18/57 (32%)
		NF-X1-zinc-finger	293..342	CDD:100116	17/71 (24%)
		NF-X1-zinc-finger	347..395	CDD:100116	17/48 (35%)
		NF-X1-zinc-finger	426..474	CDD:100116	26/52 (50%)
		NF-X1-zinc-finger	692..740	CDD:100116	19/48 (40%)
FAP1	NP_014375.1	RING-CH-C4HC3_NFX1	66..118	CDD:319610	17/79 (22%)
		NF-X1-zinc-finger	150..196	CDD:100116	19/49 (39%)
		NF-X1-zinc-finger	206..263	CDD:100116	18/57 (32%)
		NF-X1-zinc-finger	352..400	CDD:100116	16/47 (34%)
		NF-X1-zinc-finger	458..505	CDD:100116	24/47 (51%)
		NF-X1-zinc-finger	604..655	CDD:100116	20/59 (34%)
		R3H_unknown_2	736..794	CDD:100076
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1952
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810