DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15011 and NFX1

DIOPT Version :9

Sequence 1:	NP_647879.1	Gene:	CG15011 / 38518	FlyBaseID:	FBgn0035518	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_001305687.1	Gene:	NFX1 / 4799	HGNCID:	7803	Length:	1121	Species:	Homo sapiens

Alignment Length:	889	Identity:	262/889 - (29%)
Similarity:	356/889 - (40%)	Gaps:	234/889 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EKFNKAQAKNLAAAQKLVDTYASSSEDEGEL-----------------DENHILELLYKNYKPSD 49
            :..|:..||:...::.|.....||...:.|.                 .:||:|    ||.:  .
Human   284 DDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVL----KNVE--T 342

  Fly    50 NAGSSKEAARTSTFLENTLHSGAATCLICIGSIRRVEAIWSCESCYCFFHLKCIQRWANDSMMQM 114
            :.||..|...|..:          .|::|...:|....:|||:|||..|||.||::||.....|
Human   343 HTGSLIEQLTTEKY----------ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQ- 396

  Fly   115 KVKAAEQQNGQGHYNHLGEFVPPKRQKSLHWCCPKCRRDYQPADKPTQYNCFCGKEVNPENQPFL 179
                |:.|:|                    |.||.|:.  ..|..|..|.|||||..|||.....
Human   397 ----ADGQSG--------------------WRCPACQN--VSAHVPNTYTCFCGKVKNPEWSRNE 435

  Fly   180 VPHSCGEHCGKLLQP--KCGHDCKLLCHPGPCPPCAQQAQVSCLCGKSSPRSVRCIDK-QWTCQQ 241
            :||||||.|.| .||  .|.|.|.|||||||||||......:|.||::. .:|||... ...|..
Human   436 IPHSCGEVCRK-KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTR-HTVRCGQAVSVHCSN 498

  Fly   242 TCKELLACGKHKCNQVCHQPGKCPPCTSKSLQPCECQRESKMVNC------SD--RKWKCQNVCG 298
            .|:.:|.||:|:|.::|| .|:|.||.....|.|.|...|:.|.|      ||  ..:.|..:||
Human   499 PCENILNCGQHQCAELCH-GGQCQPCQIILNQVCYCGSTSRDVLCGTDVGKSDGFGDFSCLKICG 562

  Fly   299 APFACGLHICEKVCHAGPCGDGEC---PLQVRSCPCGK----------NTQVRPCNETEETCGDT 350
            ....||.|.|.:|||..||  .:|   |..||.||||:          ::..:.|.:...:||..
Human   563 KDLKCGNHTCSQVCHPQPC--QQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKV 625

  Fly   351 CQKLLSCGQ----HTCTQRCHRGPCISCPIRTKKKCRCGLHEKELPCSK-------EFACETKCK 404
            |.|.|.||.    |||.:.||.|.|..|...:...|||....|||||:.       .|.|:.:|.
Human   626 CGKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEADATFMCDKRCN 690

  Fly   405 QMRDCGKHACNRKCCGDQCPPCEKICGKQLSCNKHKCQSVCHNGPCYPCKLES--QINCRCGKT- 466
            :.|.||:|.||..||.|:...|..|||::|.|..|:|:..||.|.|..|...|  ::.|.||.:
Human   691 KKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASV 755

  Fly   467 -KKSVPCGRERSARIVCLELCRITPKCHHAIKHRCHKGD-CPPCGQVCGLPNDTSKCGHICKARC 529
             ...||||.....   |.:.|....:|.|.:.|.||..: ||||..:      |.|
Human   756 IYPPVPCGTRPPE---CTQTCARVHECDHPVYHSCHSEEKCPPCTFL------TQK--------- 802

  Fly   530 HEAVRVNKPKEARPQAKKYEYKALPHPRCEEGVIVTCIGGHEV-ATWPCWNSKPTSCQRSCARQL 593
                                               .|:|.||. :..|| :....||...|:..|
Human   803 -----------------------------------WCMGKHEFRSNIPC-HLVDISCGLPCSATL 831

  Fly   594 KCGNHKCSLVCH----FVPLPQDMSAQTGCANCEEGCTVPRPTGCIHACPKGCH---PPPCAPCN 651
            .||.|||..:||    .|..|           |::.||.|| ..|.|.|...||   |.|...|.
Human   832 PCGMHKCQRLCHKGECLVDEP-----------CKQPCTTPR-ADCGHPCMAPCHTSSPCPVTACK 884

  Fly   652 FVIKTKCHCGLNQLVYKCNEYYDETGSVQEIIERREKLRSCGNRCLKNYPCGHRCTAICHTGKCP 716
            ..::.:|.||                       ||:::..| :.....|   .|..||....|..
Human   885 AKVELQCECG-----------------------RRKEMVIC-SEASSTY---QRIAAISMASKIT 922

  Fly   717 NPELCRKKVRIFCACKRL--KQEIACDKHRAGQTFLDCDSNCKAEQIRVQAAEQLQLEQKRRDEE 779
            :.:| ...|.|    .:|  |:|:    |:|.   |:||..|.|.:.:.:.||...:.:   |.:
Human   923 DMQL-GGSVEI----SKLITKKEV----HQAR---LECDEECSALERKKRLAEAFHISE---DSD 972

  Fly   780 ERN-RLELEKF----------EAKFGKRKHKERKTVGSGPAKTK 812
            ..| |....||          :.||.....||.:|:.....|.|
Human   973 PFNIRSSGSKFSDSLKEDARKDLKFVSDVEKEMETLVEAVNKGK 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15011	NP_647879.1	NF-X1-zinc-finger	184..228	CDD:100116	24/45 (53%)
		NF-X1-zinc-finger	239..288	CDD:100116	19/54 (35%)
		NF-X1-zinc-finger	293..342	CDD:100116	21/61 (34%)
		NF-X1-zinc-finger	347..395	CDD:100116	23/51 (45%)
		NF-X1-zinc-finger	426..474	CDD:100116	20/51 (39%)
		NF-X1-zinc-finger	692..740	CDD:100116	12/49 (24%)
NFX1	NP_001305687.1	Interaction with PABPC1 and PABC4. /evidence=ECO:0000269\|PubMed:17267499	9..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..295		3/10 (30%)
		NF-X1-zinc-finger	496..544	CDD:100116	19/48 (40%)
		NF-X1-zinc-finger	557..599	CDD:100116	20/43 (47%)
		NF-X1-zinc-finger	622..674	CDD:100116	23/51 (45%)
		NF-X1-zinc-finger	685..733	CDD:100116	20/47 (43%)
		NF-X1-zinc-finger	712..764	CDD:100116	20/51 (39%)
		NF-X1-zinc-finger	823..868	CDD:100116	19/56 (34%)
		R3H_NF-X1	988..1061	CDD:100072	7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1082..1110
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1952
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D299100at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820