DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15011 and Nfxl1

DIOPT Version :9

Sequence 1:	NP_647879.1	Gene:	CG15011 / 38518	FlyBaseID:	FBgn0035518	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_598682.2	Gene:	Nfxl1 / 100978	MGIID:	1923646	Length:	918	Species:	Mus musculus

Alignment Length:	862	Identity:	366/862 - (42%)
Similarity:	481/862 - (55%)	Gaps:	70/862 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EKFNKAQAKNLAAAQKLVDTY-ASSSEDEGELD----ENHILELLYKNYKPSDNAGSSKEAARTS 61
            :||.:.:..|.|||:||::.: :||||:||:.|    :..|:...:..| .:...|...|..||.
Mouse    90 KKFEEIKKSNQAAARKLLEEHCSSSSEEEGDEDLEGKQGKIVANTFTTY-TTHTDGDIHELERTK 153

  Fly    62 TFLENTLHSGAATCLICIGSIRRVEAIWSCESCYCFFHLKCIQRWANDSMMQMKVKAAEQQNGQG 126
            .:|.....:||.||||||.|::|.:|:|||..|:|.||:.|||:||.||  |..|.:....:
Mouse   154 QYLNEAFQAGAMTCLICIASVKRNQAVWSCSGCFCIFHMPCIQKWAKDS--QFLVSSVTDDD--- 213

  Fly   127 HYNHLGEFVPPKRQKSLHWCCPKCRRDYQPADKPTQYNCFCGKEVNPENQPFLVPHSCGEHCGKL 191
                .|       :|...|.|||||.:|:.::.|::|.|:|||..:|...|:|||||||:.|.:.
Mouse   214 ----FG-------KKDYPWPCPKCRFEYKRSETPSRYYCYCGKVEDPPLDPWLVPHSCGQVCERE 267

  Fly   192 LQPKCGHDCKLLCHPGPCPPCAQQAQVSCLCGKSSPRSVRCIDKQWTCQQTCKELLACGKHKCNQ 256
            .:|.|||.|.|||||||||||.:....:|.|.|:.|...||..|||:||..|...|.||.|||..
Mouse   268 FKPSCGHKCLLLCHPGPCPPCPKMVTTTCYCKKAKPIPRRCSAKQWSCQLPCGRKLLCGHHKCEN 332

  Fly   257 VCHQPGKCPPCTSKSLQPCECQRESKMVNCSDRKWKCQNVCGAPFACGLHICEKVCHAGPCGDGE 321
            .|| .|.|.||...|.|.|.|.::....:|:...|.|..|||....||.|.||:|||.|.|  ||
Mouse   333 PCH-AGNCQPCPRVSRQKCVCGKKVAERSCASPVWHCDQVCGKTLPCGNHTCEQVCHVGAC--GE 394

  Fly   322 CPLQ-VRSCPCGKNTQVRPCNETEETCGDTCQKLLSCGQHTCTQRCHRGPCISCPIRTKKKCRCG 385
            ||.. .|||||.|:....||.|...||||:|.|:|.||.|.|:||||||||.:|....:|:||||
Mouse   395 CPRSGKRSCPCQKSKFSLPCTEDVPTCGDSCDKILECGIHRCSQRCHRGPCETCRQEVEKQCRCG 459

  Fly   386 LHEKELPCSKEFACETKCKQMRDCGKHACNRKCCGDQCPPCEKICGKQLSCNKHKCQSVCHNGPC 450
            .|.|.:||.|.:.|||||.:||||.||.|.||||...||||::.||:.|.|..|||.||||.|.|
Mouse   460 KHTKRMPCHKPYLCETKCVKMRDCQKHQCRRKCCPGNCPPCDQNCGRTLGCRNHKCPSVCHRGSC 524

  Fly   451 YPCKLESQINCRCGKTKKSVPCGRERSAR-IVCLELCRITPKCHHAI--KHRCHKGDCPPCGQVC 512
            |||.....:.|.||..|.:|||||||:.| ..|.|||...|.||||.  |||||.|.||||.|.|
Mouse   525 YPCPETVDVKCNCGNAKVTVPCGRERTTRPPKCKELCSRPPTCHHASQEKHRCHFGPCPPCHQPC 589

  Fly   513 GLPNDTSKCGHICKARCHEAVRVNK--------PKEARPQAKKYEYKALPHPRCEEGVIVTCIGG 569
              .....||||:|...||:...|.:        |.| :|....:...|||.|.|:..:.|.|:|.
Mouse   590 --QKVLEKCGHLCPESCHDQALVKQTGRHQPSGPWE-QPAEPAFIQTALPCPPCQVPIPVECLGK 651

  Fly   570 HEVATWPCWNSKPTSCQRSCARQLKCGNHKCSLVCHFVPLPQDMSAQTG-------CANCEEGCT 627
            |||:..||....|.||:|.|.|.|:|.||.|...||.|   .::.:.||       |.:|||||:
Mouse   652 HEVSPLPCHAVGPYSCKRLCGRMLRCQNHTCMKECHKV---TEVDSSTGKNKAGPECFHCEEGCS 713

  Fly   628 VPRPTGCIHACPKGCHPPPCAPCNFVIKTKCHCGLNQLVYKCNEYYDETGSVQEIIERREKLRSC 692
            ..||.||.|.|...|||..|.||..:::.||||.:..|..:|.:.  .|..|.|    :..|..|
Mouse   714 KSRPAGCPHPCVLPCHPGKCPPCVQMLRIKCHCKITSLYVECRKI--TTADVSE----KNLLSCC 772

  Fly   693 GNRCLKNYPCGHRCTAICHTGKCP-NPELCRKKVRIFCACKRLKQEIACDKHRAGQTFLDCDSNC 756
            .|:|.|..||||||..:||.|:|| |   |.:||::.|.|||:|:|:.|:|.|..|..::||:.|
Mouse   773 KNQCPKELPCGHRCKEMCHPGECPFN---CNQKVKLRCPCKRIKRELPCNKVRENQVSVECDATC 834

  Fly   757 KAEQIRVQAAEQLQLEQKRRDEEERNRLELEKFEAKFGKRKHKERK----TVGSGPAKTKIDWQR 817
            |..:.:....::.:......:|:.|.:.|||.||.:...|:.|.||    .|...|      ||:
Mouse   835 KEMKRKASEVKEAEANAALEEEKRRQQAELEAFENRLKGRRKKSRKRDEVAVELSP------WQK 893

  Fly   818 RAIYAVSILTVVGAIVV 834
            ...|.:.:..||.|:::
Mouse   894 YKSYLLPVCAVVVAVLM 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15011	NP_647879.1	NF-X1-zinc-finger	184..228	CDD:100116	22/43 (51%)
		NF-X1-zinc-finger	239..288	CDD:100116	20/48 (42%)
		NF-X1-zinc-finger	293..342	CDD:100116	26/49 (53%)
		NF-X1-zinc-finger	347..395	CDD:100116	28/47 (60%)
		NF-X1-zinc-finger	426..474	CDD:100116	24/47 (51%)
		NF-X1-zinc-finger	692..740	CDD:100116	25/48 (52%)
Nfxl1	NP_598682.2	RING-CH finger (C4HC3-type)	167..226	CDD:319611	29/74 (39%)
		NF-X1-zinc-finger	315..363	CDD:100116	20/48 (42%)
		NF-X1-zinc-finger	368..416	CDD:100116	26/49 (53%)
		NF-X1-zinc-finger	421..469	CDD:100116	28/47 (60%)
		NF-X1-zinc-finger	500..548	CDD:100116	24/47 (51%)
		NF-X1-zinc-finger	708..755	CDD:100116	22/46 (48%)
		NF-X1-zinc-finger	772..818	CDD:100116	25/48 (52%)
		RING-CH-C4HC3_NFXL1	165..227	CDD:319611	31/77 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848145
Domainoid	1	1.000	146	1.000	Domainoid score	I4541
eggNOG	1	0.900	-	-		E1_KOG1952
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26752
Inparanoid	1	1.050	759	1.000	Inparanoid score	I550
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51847
OrthoDB	1	1.010	-	-		D299100at2759
OrthoFinder	1	1.000	-	-		FOG0006258
OrthoInspector	1	1.000	-	-		oto94065
orthoMCL	1	0.900	-	-		OOG6_106113
Panther	1	1.100	-	-	LDO	PTHR12360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5752
SonicParanoid	1	1.000	-	-		X4539
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800