DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and BTRC

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	XP_006718117.1	Gene:	BTRC / 8945	HGNCID:	1144	Length:	732	Species:	Homo sapiens

Alignment Length:	760	Identity:	215/760 - (28%)
Similarity:	320/760 - (42%)	Gaps:	154/760 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   604 ASAQTQERFL-----TRSNPPAASGAG-----SVGANPTASVRQ-------RRNGSSD------- 644
            |.|..||:.|     .|..|....|||     .:|..|||....       ||:|..|
Human     4 AEAVLQEKALKFMVRRRWRPGNGGGAGVGGVAGLGRPPTAGPGSGTLGRGWRRSGWRDGMGAPER 68

  Fly   645 --------------VVHL--------EVVVEEGAGGGDGGVVEPGDFSAEEPWANCDEENNCSDL 687
                          :.||        ..::||||.||..|   ||...|   |.
Human    69 RLGVAERTQGWGQRLRHLVDERPSDSGSLIEEGAPGGARG---PGGKGA---WG----------- 116

  Fly   688 EEICTCQNGNGSSYGGSNASLSETFDMDAMDPDEPISLSLSSASAGFTEYSLT---NP-----SS 744
                ......|||......:....|.:..:....|.||.|..:|...:..||.   ||     ::
Human   117 ----LLLKSGGSSLEKRREAAGGAFLVSGLPCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTA 177

  Fly   745 LMSHQRKRKFNEGR-----LLDGGDYSVTISSSGEVGGPGSGVSDNCRKRIAYDFASTPRSSQHL 804
            ..:...:...|.|.     :.:......|.:|...:          |..:.....|||...:::.
Human   178 FQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARL----------CLNQETVCLASTAMKTENC 232

  Fly   805 GPTAVLSVTPSSHLTSSTPGSALGRRTPRSVPSRDNPPPELQHWLAQFQRWSHVERLLALDRLID 869
            .....|:...||.:            .|:......:...|.:..:..|::||..:::..::.||.
Human   233 VAKTKLANGTSSMI------------VPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLIS 285

  Fly   870 HCDPSQVRHMMKVIEPQFQRDFISLLPR----ELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNL 930
            .....|..|:...::|..|||||:.||.    .:|..:||||:.|.|..|...|:.|..:..|.:
Human   286 QMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGM 350

  Fly   931 LWKEKCRKA-------QILAEPR-------SDRPKRGRDGNMPPIASPWKAAYMR--QHI--IEM 977
            |||:...:.       :.|||.|       .::|.   |||.|| .|.::|.|.:  |.|  ||.
Human   351 LWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPP---DGNAPP-NSFYRALYPKIIQDIETIES 411

  Fly   978 NWR------SRPVRKPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTG 1036
            |||      .|...:.:..||     :.|||:...:||||..|||:|:|.....:|.|.|.||||
Human   412 NWRCGRHSLQRIHCRSETSKG-----VYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTG 471

  Fly  1037 GVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDATLRVWD 1101
            .|...|....:||:||:|.|::|||:::|..::||..|...|..:..:...:|:.|:|.::.|||
Human   472 SVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWD 536

  Fly  1102 IEQGSCL---HVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQF 1163
            :...:.:   .|||||.|||..|.:|.|.|||.:.|..:|:|:....|.:.||.||...:..||:
Human   537 MASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQY 601

  Fly  1164 DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGNADSTVKVWDITTG--- 1225
            ....|||||.|.:||:||:|.|.|...|.||:.|...:......:|||..|..:||||:...
Human   602 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDP 666

  Fly  1226 ------QCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWD 1264
                  .||:||.   :|...|..|||:...:|:||.|.|:.:||
Human   667 RAPAGTLCLRTLV---EHSGRVFRLQFDEFQIVSSSHDDTILIWD 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689	17/49 (35%)
		WD40	<981..1274	CDD:225201	109/296 (37%)
		WD40	988..1264	CDD:238121	106/287 (37%)
		WD40 repeat	998..1033	CDD:293791	15/34 (44%)
		WD40 repeat	1039..1073	CDD:293791	13/33 (39%)
		WD40 repeat	1078..1112	CDD:293791	8/36 (22%)
		WD40 repeat	1119..1152	CDD:293791	11/32 (34%)
		WD40 repeat	1158..1192	CDD:293791	15/33 (45%)
		WD40 repeat	1200..1232	CDD:293791	11/40 (28%)
		WD40 repeat	1241..1263	CDD:293791	9/21 (43%)
BTRC	XP_006718117.1	Beta-TrCP_D	266..304	CDD:288940	8/37 (22%)
		F-box-like	308..355	CDD:289689	17/46 (37%)
		WD40	<417..713	CDD:225201	109/300 (36%)
		WD40	430..708	CDD:238121	106/285 (37%)
		WD40 repeat	433..468	CDD:293791	15/34 (44%)
		WD40 repeat	474..508	CDD:293791	13/33 (39%)
		WD40 repeat	513..550	CDD:293791	8/36 (22%)
		WD40 repeat	557..590	CDD:293791	11/32 (34%)
		WD40 repeat	596..630	CDD:293791	15/33 (45%)
		WD40 repeat	636..679	CDD:293791	11/42 (26%)
		WD40 repeat	685..707	CDD:293791	9/21 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D150270at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950