DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ago and UFO1

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_013622.1	Gene:	UFO1 / 854886	SGDID:	S000004553	Length:	668	Species:	Saccharomyces cerevisiae

Alignment Length:	456	Identity:	89/456 - (19%)
Similarity:	150/456 - (32%)	Gaps:	165/456 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   895 LPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRPKRGRDGNMP 959
            ||.|:.:.:.|:|:.|||....:....:|.|..|..|||...:             .|....:.|
Yeast    11 LPPEILINIFSHLDEKDLFTLQELSTHFRNLIHDEELWKNLFK-------------SRVHTTHFP 62

  Fly   960 PI--ASPWKAAYMR--------QH----------IIEMNWRSRPVRK-----PKVLKGHDDHVIT 999
            ..  :|.:...|:.        ||          |...||....:.:     |:| ..::|..||
Yeast    63 TFSQSSKFSVEYIERTRGLHHWQHNKAIRTKYTIIPTRNWDQPSIERIVFDYPRV-AAYNDGTIT 126

  Fly  1000 CLQ----------------------------FSGNRIVSGSDDNTLKVWSAVNGKCLRT------ 1030
            .||                            |:.|..|.|..|      ..|.||.|..
Yeast   127 ILQLQNHKRQKKFKKLIYIPCTTPQGCSTMDFNINAAVFGRFD------GRVFGKLLSNKSYLTP 185

  Fly  1031 ---LVG-HTGGV---------------WSSQMSGN-IIISGSTDRTLKVW--------------- 1060
               ..| |:.||               ||...|.| .||....::.:|:|
Yeast   186 VMEFTGRHSAGVTAICNSESWDTSREDWSVSGSENGEIIWWCENKLVKMWKVSNRVIWKLAFFKD 250

  Fly  1061 -----DMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDATLRV--WDIEQGSCLHVLVGHLAAV 1118
                 |.:....:|.:|         .||...:.....:..:||  :.::.||...|    ||.:
Yeast   251 WTLIMDDEKLYIIHQMQ---------ELHSIDIPKDLDEQPMRVRFFKMDFGSMTLV----LADL 302

  Fly  1119 RCVQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTN-RVYSLQF---DGLHVVSGSLDTSIRV 1179
            ..| |...:..:|.:..:.|:..|| |.|...:...|: |..:.||   ||.::   ||.|
Yeast   303 NNV-YTISVNPNGNFGNLRKLEMPE-QICAVEIDEKTSQREQNWQFAGDDGCYI---SLLT---- 358

  Fly  1180 WDVETGNCKHTLMGHQSLTSGMELR--------------QNILVSGNADSTVKVWDITTGQCLQT 1230
                |.|..:.:......:||::::              .|::|.....:.:::.:..||:.::|
Yeast   359 ----TQNTLYIINIRDLSSSGLKVQCKISFDEQVYVSQVTNLIVVVALPNVLQILNAMTGELIKT 419

  Fly  1231 L 1231
            :
Yeast   420 V 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689	14/42 (33%)
		WD40	<981..1274	CDD:225201	66/350 (19%)
		WD40	988..1264	CDD:238121	65/338 (19%)
		WD40 repeat	998..1033	CDD:293791	13/71 (18%)
		WD40 repeat	1039..1073	CDD:293791	10/54 (19%)
		WD40 repeat	1078..1112	CDD:293791	7/35 (20%)
		WD40 repeat	1119..1152	CDD:293791	8/32 (25%)
		WD40 repeat	1158..1192	CDD:293791	9/36 (25%)
		WD40 repeat	1200..1232	CDD:293791	6/46 (13%)
		WD40 repeat	1241..1263	CDD:293791
UFO1	NP_013622.1	F-box-like	8..52	CDD:403981	14/40 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0274
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900