DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and CAF4

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_012962.3	Gene:	CAF4 / 853908	SGDID:	S000001744	Length:	643	Species:	Saccharomyces cerevisiae

Alignment Length:	289	Identity:	84/289 - (29%)
Similarity:	135/289 - (46%)	Gaps:	60/289 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1045 GNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHL---HGSKVVSGSRDATLRVWDIEQGS 1106
            |.:..|...||.:||||::.|..|..|.||.:||.||.:   :.:.:::||:||||::||:....
Yeast   332 GTLCSSSYQDRIVKVWDLNHGIQVGELPGHLATVNCMQIDKKNYNMLITGSKDATLKLWDLNLSR 396

  Fly  1107 CLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQFDGLHVVSG 1171
              .:.:.|               |...:...:|..|    |:|..:.|.:.:.:|.||...:|||
Yeast   397 --EIYLDH---------------SPLKEKTEEIVTP----CIHNFELHKDEITALSFDSEALVSG 440

  Fly  1172 SLDTSIRVWDVETGNCKHTL------------MGHQSLTSG-------------MELRQNILVSG 1211
            |.|..|..||:.||.|...|            |..:||.:|             ::...:.|.:|
Yeast   441 SRDKKIFHWDLTTGKCIQQLDLIFTPTHSDIKMPARSLNNGACLLGTEAPMIGALQCYNSALATG 505

  Fly  1212 NADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFIRNLVA 1276
            ..|..|::||:..|:.::.|.|   |...:|.|:|:|..:||.|.|.:|::||::|.. |.:::|
Yeast   506 TKDGIVRLWDLRVGKPVRLLEG---HTDGITSLKFDSEKLVTGSMDNSVRIWDLRTSS-ILDVIA 566

  Fly  1277 LDSGGSGGVVWRIRANDTKLICAVGSRNG 1305
            .|...|.      ...|.||| .||:..|
Yeast   567 YDLPVSS------LDFDGKLI-TVGANEG 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689
		WD40	<981..1274	CDD:225201	74/256 (29%)
		WD40	988..1264	CDD:238121	70/246 (28%)
		WD40 repeat	998..1033	CDD:293791
		WD40 repeat	1039..1073	CDD:293791	11/27 (41%)
		WD40 repeat	1078..1112	CDD:293791	11/36 (31%)
		WD40 repeat	1119..1152	CDD:293791	5/32 (16%)
		WD40 repeat	1158..1192	CDD:293791	15/45 (33%)
		WD40 repeat	1200..1232	CDD:293791	8/44 (18%)
		WD40 repeat	1241..1263	CDD:293791	9/21 (43%)
CAF4	NP_012962.3	Caf4	65..124	CDD:402971
		WD40	318..641	CDD:238121	84/289 (29%)
		WD40 repeat	322..360	CDD:293791	11/27 (41%)
		WD40 repeat	366..422	CDD:293791	16/76 (21%)
		WD40 repeat	427..461	CDD:293791	14/33 (42%)
		WD40 repeat	472..526	CDD:293791	11/53 (21%)
		WD40 repeat	532..563	CDD:293791	13/31 (42%)
		WD40 repeat	571..611	CDD:293791	8/25 (32%)
		WD40 repeat	617..641	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840