DRSC/TRiP Functional Genomics Resources

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Protein Alignment ago and FBXW9

DIOPT Version :10

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_115677.2 Gene:FBXW9 / 84261 HGNCID:28136 Length:458 Species:Homo sapiens


Alignment Length:553 Identity:131/553 - (23%)
Similarity:201/553 - (36%) Gaps:149/553 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   786 CRKRIAYDFASTPRSSQHLGPTA--------VLSVTPSSHLTSSTPGSALGRRTPRSVPSRDNPP 842
            |.....:|..|.|.|  ...|.|        ||| .|.|.|..|.|...   .||.:.||..   
Human     8 CDDSRTWDDDSDPES--ETDPDAQAKAYVARVLS-PPKSGLAFSRPSQL---STPAASPSAS--- 63

  Fly   843 PELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVLSYL 907
                                         :|.....:..|.||.     :..||.||.|.:.|||
Human    64 -----------------------------EPRAASRVSAVSEPG-----LLSLPPELLLEICSYL 94

  Fly   908 EPKDLLRA-AQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRP---KRGRDGNMPPIASPWKAA 968
            :.:.:|.. ::.|.:.|.|..|::.|     :.:.|...|:..|   ::..|         |.||
Human    95 DARLVLHVLSRVCHALRDLVSDHVTW-----RLRALRRVRAPYPVVEEKNFD---------WPAA 145

  Fly   969 --YMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSGNRI-VSGSDDNTLKVW------SAVN 1024
              .:.||:.......|.|....:.:||...|.:.|...|..: :|||.|..:.:|      :..|
Human   146 CIALEQHLSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESN 210

  Fly  1025 GKCLRTL-----VGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLH 1084
            ...::||     ..|.|.|||.....:.:.|||.|.|:|:|||                      
Human   211 QVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDM---------------------- 253

  Fly  1085 GSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECL- 1148
               ...|.:...::.               .:||.|:.|...::|:|.||..|.|:.|.....| 
Human   254 ---AADGQQFGEIKA---------------SSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALL 300

  Fly  1149 -HTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGN 1212
             |. |.|:..|.:|..|..|::|||.|.::.|.|....:....|.....|.. |..::..|.:|:
Human   301 KHQ-QLHSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSYLLC-MSYQEPQLWAGD 363

  Fly  1213 ADSTVKVWDITTGQCLQTLSGPNKHHS-AVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFIR---- 1272
            ....:.|:....| |.|.:...:..|| .:|.:|::...:.|:|.|.|::: .|.| |..|    
Human   364 NQGLLHVFANRNG-CFQLIRSFDVGHSFPITGIQYSVGALYTTSTDKTIRV-HVPT-DPPRTICT 425

  Fly  1273 --------------NLVALDSGGSGGVVWRIRA 1291
                          |||...||.....|||::|
Human   426 RRHDNGLNRVCAEGNLVVAGSGDLSLEVWRLQA 458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box_FBXW7 875..933 CDD:438905 16/58 (28%)
WD40 <979..1267 CDD:441893 73/302 (24%)
WD40 repeat 998..1033 CDD:293791 10/46 (22%)
WD40 repeat 1039..1073 CDD:293791 11/33 (33%)
WD40 repeat 1078..1112 CDD:293791 1/33 (3%)
WD40 repeat 1119..1152 CDD:293791 11/34 (32%)
WD40 repeat 1158..1192 CDD:293791 10/33 (30%)
WD40 repeat 1200..1232 CDD:293791 7/31 (23%)
WD40 repeat 1241..1263 CDD:293791 6/21 (29%)
FBXW9NP_115677.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..64 8/56 (14%)
F-box_SF <89..120 CDD:459239 8/30 (27%)
WD40 <170..457 CDD:441893 82/331 (25%)
WD 1. /evidence=ECO:0000255 171..210 10/38 (26%)
WD40 repeat 177..222 CDD:293791 10/44 (23%)
WD 2. /evidence=ECO:0000255 220..261 15/65 (23%)
WD40 repeat 227..262 CDD:293791 14/59 (24%)
WD 3. /evidence=ECO:0000255 264..301 12/51 (24%)
WD40 repeat 270..301 CDD:293791 10/30 (33%)
WD40 repeat 305..344 CDD:293791 11/38 (29%)
WD 4. /evidence=ECO:0000255 305..342 11/36 (31%)
WD 5. /evidence=ECO:0000255 344..381 8/38 (21%)
WD40 repeat 350..385 CDD:293791 7/36 (19%)
WD 6. /evidence=ECO:0000255 387..424 12/38 (32%)
WD40 repeat 392..413 CDD:293791 6/20 (30%)
WD 7. /evidence=ECO:0000255 427..458 8/30 (27%)

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