DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and FBXW9

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_115677.2	Gene:	FBXW9 / 84261	HGNCID:	28136	Length:	458	Species:	Homo sapiens

Alignment Length:	553	Identity:	131/553 - (23%)
Similarity:	201/553 - (36%)	Gaps:	149/553 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   786 CRKRIAYDFASTPRSSQHLGPTA--------VLSVTPSSHLTSSTPGSALGRRTPRSVPSRDNPP 842
            |.....:|..|.|.|  ...|.|        ||| .|.|.|..|.|...   .||.:.||..
Human     8 CDDSRTWDDDSDPES--ETDPDAQAKAYVARVLS-PPKSGLAFSRPSQL---STPAASPSAS--- 63

  Fly   843 PELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVLSYL 907
                                         :|.....:..|.||.     :..||.||.|.:.|||
Human    64 -----------------------------EPRAASRVSAVSEPG-----LLSLPPELLLEICSYL 94

  Fly   908 EPKDLLRA-AQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRP---KRGRDGNMPPIASPWKAA 968
            :.:.:|.. ::.|.:.|.|..|::.|     :.:.|...|:..|   ::..|         |.||
Human    95 DARLVLHVLSRVCHALRDLVSDHVTW-----RLRALRRVRAPYPVVEEKNFD---------WPAA 145

  Fly   969 --YMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSGNRI-VSGSDDNTLKVW------SAVN 1024
              .:.||:.......|.|....:.:||...|.:.|...|..: :|||.|..:.:|      :..|
Human   146 CIALEQHLSRWAEDGRWVEYFCLAEGHVASVDSVLLLQGGSLCLSGSRDRNVNLWDLRQLGTESN 210

  Fly  1025 GKCLRTL-----VGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLH 1084
            ...::||     ..|.|.|||.....:.:.|||.|.|:|:|||
Human   211 QVLIKTLGTKRNSTHEGWVWSLAAQDHRVCSGSWDSTVKLWDM---------------------- 253

  Fly  1085 GSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECL- 1148
               ...|.:...::.               .:||.|:.|...::|:|.||..|.|:.|.....|
Human   254 ---AADGQQFGEIKA---------------SSAVLCLSYLPDILVTGTYDKKVTIYDPRAGPALL 300

  Fly  1149 -HTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGN 1212
             |. |.|:..|.:|..|..|::|||.|.::.|.|....:....|.....|.. |..::..|.:|:
Human   301 KHQ-QLHSRPVLTLLADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSYLLC-MSYQEPQLWAGD 363

  Fly  1213 ADSTVKVWDITTGQCLQTLSGPNKHHS-AVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFIR---- 1272
            ....:.|:....| |.|.:...:..|| .:|.:|::...:.|:|.|.|::: .|.| |..|
Human   364 NQGLLHVFANRNG-CFQLIRSFDVGHSFPITGIQYSVGALYTTSTDKTIRV-HVPT-DPPRTICT 425

  Fly  1273 --------------NLVALDSGGSGGVVWRIRA 1291
                          |||...||.....|||::|
Human   426 RRHDNGLNRVCAEGNLVVAGSGDLSLEVWRLQA 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689	14/46 (30%)
		WD40	<981..1274	CDD:225201	76/325 (23%)
		WD40	988..1264	CDD:238121	70/290 (24%)
		WD40 repeat	998..1033	CDD:293791	10/46 (22%)
		WD40 repeat	1039..1073	CDD:293791	11/33 (33%)
		WD40 repeat	1078..1112	CDD:293791	1/33 (3%)
		WD40 repeat	1119..1152	CDD:293791	11/34 (32%)
		WD40 repeat	1158..1192	CDD:293791	10/33 (30%)
		WD40 repeat	1200..1232	CDD:293791	7/31 (23%)
		WD40 repeat	1241..1263	CDD:293791	6/21 (29%)
FBXW9	NP_115677.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64		8/56 (14%)
		WD40	170..413	CDD:421866	70/285 (25%)
		WD 1. /evidence=ECO:0000255	171..210		10/38 (26%)
		WD40 repeat	177..222	CDD:293791	10/44 (23%)
		WD 2. /evidence=ECO:0000255	220..261		15/65 (23%)
		WD40 repeat	227..262	CDD:293791	14/59 (24%)
		WD 3. /evidence=ECO:0000255	264..301		12/51 (24%)
		WD40 repeat	270..301	CDD:293791	10/30 (33%)
		WD40 repeat	305..344	CDD:293791	11/38 (29%)
		WD 4. /evidence=ECO:0000255	305..342		11/36 (31%)
		WD 5. /evidence=ECO:0000255	344..381		8/38 (21%)
		WD40 repeat	350..385	CDD:293791	7/36 (19%)
		WD 6. /evidence=ECO:0000255	387..424		12/38 (32%)
		WD40 repeat	392..413	CDD:293791	6/20 (30%)
		WD 7. /evidence=ECO:0000255	427..458		8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0274
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810