DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ago and TRAF7

DIOPT Version :9

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_115647.2 Gene:TRAF7 / 84231 HGNCID:20456 Length:670 Species:Homo sapiens


Alignment Length:275 Identity:85/275 - (30%)
Similarity:125/275 - (45%) Gaps:46/275 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   992 GHDDHV-ITCLQFSGNRIVSGSDDNTLKVW-SAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTD 1054
            ||...| ..|:...|:.:.|||.|.|:||| :....||.:||.||.|.|.:..:.|..:.|||.|
Human   394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSAD 458

  Fly  1055 RTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDA------------------------ 1095
            .|:.|||:.:...|:|::.|.:.|..:....:.:.|||..|                        
Human   459 CTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWV 523

  Fly  1096 ----------------TLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPER 1144
                            |:::|||....|:|||.....:|..:......||.|.|:.::.:|..|.
Human   524 RALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIES 588

  Fly  1145 QECLHTLQGHTNRVYSLQF----DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQ 1205
            :|.:.||.||...||:|..    |...|.|.|.|.|:|||.::...|..||:.||...:.:.:.:
Human   589 KEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSR 653

  Fly  1206 NILVSGNADSTVKVW 1220
            ..|.||..|||||||
Human   654 GRLFSGAVDSTVKVW 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box-like 892..938 CDD:289689
WD40 <981..1274 CDD:225201 85/275 (31%)
WD40 988..1264 CDD:238121 85/275 (31%)
WD40 repeat 998..1033 CDD:293791 14/35 (40%)
WD40 repeat 1039..1073 CDD:293791 11/33 (33%)
WD40 repeat 1078..1112 CDD:293791 12/73 (16%)
WD40 repeat 1119..1152 CDD:293791 8/32 (25%)
WD40 repeat 1158..1192 CDD:293791 14/37 (38%)
WD40 repeat 1200..1232 CDD:293791 10/21 (48%)
WD40 repeat 1241..1263 CDD:293791
TRAF7NP_115647.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..97
RING 131..163 CDD:214546
Sina 207..>280 CDD:302762
DD_cGKI 282..322 CDD:213458
WD40 <380..668 CDD:225201 83/273 (30%)
WD40 388..668 CDD:238121 83/273 (30%)
WD 1. /evidence=ECO:0000255 394..433 15/38 (39%)
WD 2. /evidence=ECO:0000255 437..474 14/36 (39%)
WD40 repeat 443..477 CDD:293791 11/33 (33%)
WD 3. /evidence=ECO:0000255 477..513 6/35 (17%)
WD40 repeat 482..517 CDD:293791 5/34 (15%)
WD 4. /evidence=ECO:0000255 515..554 5/38 (13%)
WD40 repeat 527..556 CDD:293791 7/28 (25%)
WD 5. /evidence=ECO:0000255 557..594 8/36 (22%)
WD40 repeat 562..596 CDD:293791 9/33 (27%)
WD 6. /evidence=ECO:0000255 597..638 15/40 (38%)
WD40 repeat 604..639 CDD:293791 11/34 (32%)
WD 7. /evidence=ECO:0000255 641..669 12/28 (43%)
WD40 repeat 646..668 CDD:293791 8/21 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0274
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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