DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ago and WDR5b

DIOPT Version :9

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_192182.1 Gene:WDR5b / 828189 AraportID:AT4G02730 Length:333 Species:Arabidopsis thaliana


Alignment Length:333 Identity:101/333 - (30%)
Similarity:165/333 - (49%) Gaps:47/333 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   953 GRDGNMPPIASPWKAAYMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFS--GNRIVSGSDDN 1015
            |..||:|        .|            :|.|..|.|:|| ...|:|::||  ||.:.|.|.|.
plant    22 GTSGNVP--------IY------------KPYRHLKTLEGH-TAAISCVKFSNDGNLLASASVDK 65

  Fly  1016 TLKVWSAVNGKCLRTLVGHTGGV----WSSQMSGNIIISGSTDRTLKVWDMDSG-ACVHTLQGHT 1075
            |:.:|||.|...:....||:.|:    |||  ..:...|.|.|.||::||..|. .|:..|:|||
plant    66 TMILWSATNYSLIHRYEGHSSGISDLAWSS--DSHYTCSASDDCTLRIWDARSPYECLKVLRGHT 128

  Fly  1076 STVRCMHLH--GSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQY--DGKLIVSGAYDYM 1136
            :.|.|::.:  .:.:||||.|.|:|:|:::.|.|:.::..|...:..|.:  ||.||||.::|..
plant   129 NFVFCVNFNPPSNLIVSGSFDETIRIWEVKTGKCVRMIKAHSMPISSVHFNRDGSLIVSASHDGS 193

  Fly  1137 VKIWHPERQECLHTLQGHTNRVYSL-QF--DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQS-- 1196
            .|||..:...||.||....:...|. :|  :|..::..:||:::::.:..||.......||.:  
plant   194 CKIWDAKEGTCLKTLIDDKSPAVSFAKFSPNGKFILVATLDSTLKLSNYATGKFLKVYTGHTNKV 258

  Fly  1197 --LTSGMELRQ-NILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSD-- 1256
              :||...:.. ..:|||:.|:.|.:||:.....||.|.|......:|:|....:.  ::||.  
plant   259 FCITSAFSVTNGKYIVSGSEDNCVYLWDLQARNILQRLEGHTDAVISVSCHPVQNE--ISSSGNH 321

  Fly  1257 -DGTVKLW 1263
             |.|:::|
plant   322 LDKTIRIW 329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box-like 892..938 CDD:289689
WD40 <981..1274 CDD:225201 96/305 (31%)
WD40 988..1264 CDD:238121 94/298 (32%)
WD40 repeat 998..1033 CDD:293791 14/36 (39%)
WD40 repeat 1039..1073 CDD:293791 13/34 (38%)
WD40 repeat 1078..1112 CDD:293791 12/35 (34%)
WD40 repeat 1119..1152 CDD:293791 14/34 (41%)
WD40 repeat 1158..1192 CDD:293791 7/36 (19%)
WD40 repeat 1200..1232 CDD:293791 9/32 (28%)
WD40 repeat 1241..1263 CDD:293791 6/24 (25%)
WDR5bNP_192182.1 WD40 26..>330 CDD:225201 99/329 (30%)
WD40 35..330 CDD:238121 94/300 (31%)
WD40 repeat 46..83 CDD:293791 14/36 (39%)
WD40 repeat 89..126 CDD:293791 13/38 (34%)
WD40 repeat 131..167 CDD:293791 12/35 (34%)
WD40 repeat 174..209 CDD:293791 14/34 (41%)
WD40 repeat 216..252 CDD:293791 7/35 (20%)
WD40 repeat 260..297 CDD:293791 11/36 (31%)
WD40 repeat 303..329 CDD:293791 6/27 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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