DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and WDR5a

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_190535.1	Gene:	WDR5a / 824128	AraportID:	AT3G49660	Length:	317	Species:	Arabidopsis thaliana

Alignment Length:	310	Identity:	94/310 - (30%)
Similarity:	160/310 - (51%)	Gaps:	33/310 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   983 PVRKPKVLKGHDDHVITCLQFS--GNRIVSGSDDNTLKVW--SAVN---GKCLRTLVGHTGGVWS 1040
            |....:.|..| :..::.::||  |..:.|.|.|.|::.:  :.:|   .:.::...||..|:..
plant    13 PYVHSQTLTSH-NRAVSSVKFSSDGRLLASASADKTIRTYTINTINDPIAEPVQEFTGHENGISD 76

  Fly  1041 SQMSGN--IIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLH--GSKVVSGSRDATLRVWD 1101
            ...|.:  .|:|.|.|:|||:||:::|:.:.||.|||:...|::.:  .:.:||||.|.|:|:||
plant    77 VAFSSDARFIVSASDDKTLKLWDVETGSLIKTLIGHTNYAFCVNFNPQSNMIVSGSFDETVRIWD 141

  Fly  1102 IEQGSCLHVLVGHLAAVRCVQY--DGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYS-LQF 1163
            :..|.||.||..|...|..|.:  ||.||||.:||.:.:||......|:.||....|...| ::|
plant   142 VTTGKCLKVLPAHSDPVTAVDFNRDGSLIVSSSYDGLCRIWDSGTGHCVKTLIDDENPPVSFVRF 206

  Fly  1164 --DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQ----------SLTSGMELRQNILVSGNADST 1216
              :|..::.|:||.::|:|::.:.....|..||.          |:|:|..     :|||:.|:.
plant   207 SPNGKFILVGTLDNTLRLWNISSAKFLKTYTGHVNAQYCISSAFSVTNGKR-----IVSGSEDNC 266

  Fly  1217 VKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDVK 1266
            |.:|::.:.:.||.|.|..:....|.| ......:.:.|.|.||::|..|
plant   267 VHMWELNSKKLLQKLEGHTETVMNVAC-HPTENLIASGSLDKTVRIWTQK 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689
		WD40	<981..1274	CDD:225201	94/310 (30%)
		WD40	988..1264	CDD:238121	91/301 (30%)
		WD40 repeat	998..1033	CDD:293791	8/41 (20%)
		WD40 repeat	1039..1073	CDD:293791	13/35 (37%)
		WD40 repeat	1078..1112	CDD:293791	14/35 (40%)
		WD40 repeat	1119..1152	CDD:293791	13/34 (38%)
		WD40 repeat	1158..1192	CDD:293791	9/36 (25%)
		WD40 repeat	1200..1232	CDD:293791	9/31 (29%)
		WD40 repeat	1241..1263	CDD:293791	6/21 (29%)
WDR5a	NP_190535.1	WD40	16..312	CDD:238121	91/302 (30%)
		WD40 repeat	27..69	CDD:293791	8/41 (20%)
		WD40 repeat	75..111	CDD:293791	13/35 (37%)
		WD40 repeat	116..152	CDD:293791	14/35 (40%)
		WD40 repeat	159..194	CDD:293791	13/34 (38%)
		WD40 repeat	201..237	CDD:293791	9/35 (26%)
		WD40 repeat	245..282	CDD:293791	11/41 (27%)
		WD40 repeat	288..312	CDD:293791	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910