Protein Alignment ago and fbxw7

DIOPT Version :10

• Sequence 1: NP_523922.1
• Gene: ago / 38516
• FlyBaseID: FBgn0041171
• Length: 1326
• Species: Drosophila melanogaster
• Sequence 2: XP_021329580.1
• Gene: fbxw7 / 564991
• ZFINID: ZDB-GENE-090313-79
• Length: 835
• Species: Danio rerio
• Alignment Length: 872
• Identity: 450/872 - (51%)
• Similarity: 536/872 - (61%)
• Gaps: 146/872 - (16%)

  Fly   547 GCSRTTA----INPTAACSTGSACLGDSQASTSASTSSGAGASNRCQYATTSTTKAARQVNA--- 604
            |||..::    :..:|.||...:|...|:.....:|...:...|....:::.:....::|.:
Zfish     9 GCSFISSLMKRLGRSACCSDLLSCSHTSEHLQRLATGCPSQHKNAKSLSSSDSLAKVQEVASWLL 73

  Fly   605 -------SAQTQERFLTRSNP-PAASGAGS--VGANP----------------TASVRQRRNGSS 643
                   |..:..|...:..| |..:|||:  .|..|                ..:.:|||
Zfish    74 EMNQDLLSGGSGSRAAQQQRPRPGTAGAGNSISGRTPQPQPEHPDQVLEEPEQEEAQQQRR---- 134

  Fly   644 DVVHLEVVVEEGAGGGDGGVVEPGDFSAEEPW----------------ANCD------------- 679
                 |...||..||.:.  .:.||   |:||                .|.|
Zfish   135 -----EPAEEEDEGGPER--QQDGD---EQPWPSGGEPMEDGEGRRSEVNGDEKGAQWLWEQEQR 189

  Fly   680 -------EENNCSDLEEICTCQNGNGSSYGGSNASLSETFDMDAMDPDEPISLSLSSASAGFTEY 737
                   ||...::.||    :|.|....|...|.|....|.|..:.|......:...|..| |:
Zfish   190 RRRRPHREEEEENEEEE----ENNNSGREGQVGAGLRSEEDDDRPEEDNEGEEEMDQDSDEF-EH 249

  Fly   738 SLTNPSSLMSHQRKRKFNEGRLLDG--GDYSVTISSSGEVGGPGSGVSDN------CRKRIAYDF 794
            |       ...:|:.:..:|...:|  |.:|.::.:|         |||:      ...|.....
Zfish   250 S-------EESEREEEEEDGEEEEGEEGLHSPSLRTS---------VSDHNDNTDQSSGRQRQSL 298

  Fly   795 ASTPRSSQHL--GPTAVLSVTPSSHLTSSTP-GSALGRRTPRS----------VPSRD-----NP 841
            .|..|..:.|  ||..      .|..|...| .|..|::.|.:          ||.|.     .|
Zfish   299 RSPNRMKRKLDHGPEV------RSFTTGKKPCPSPTGQQYPATFGDLRAVNGQVPQRRRITSIQP 357

  Fly   842 PPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVLSY 906
            |..||.||..||.||..|:|||||.|||.|:|:||:|||:||||||||||||||||||||.|||:
Zfish   358 PTGLQEWLRTFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPRELALHVLSF 422

  Fly   907 LEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRP---KRGRDGNMPPIASPWKAA 968
            |||||||:||||||.||.|.:|||||||||::..|      |.|   ||.:........||||:|
Zfish   423 LEPKDLLQAAQTCRYWRILAEDNLLWKEKCKEEGI------DEPLHIKRRKVIKPGFTHSPWKSA 481

  Fly   969 YMRQHIIEMNWRSRPVRKPK-VLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSAVNGKCLRTLV 1032
            |:|||.|:.|||...::.|| |||||||||||||||.|||||||||||||||||||.||||||||
Zfish   482 YIRQHRIDTNWRRGDLKSPKVVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLV 546

  Fly  1033 GHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDATL 1097
            |||||||||||..|||||||||||||||:.::|.|:|||.||||||||||||..:||||||||||
Zfish   547 GHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATL 611

  Fly  1098 RVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQ 1162
            ||||||.|.|||||:||:||||||||||:.:||||||:|||:|.||.:.||||||||||||||||
Zfish   612 RVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 676

  Fly  1163 FDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGNADSTVKVWDITTGQC 1227
            |||:|||||||||||||||||||||.|||.|||||||||||:.|||||||||||||:|||.||||
Zfish   677 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQC 741

  Fly  1228 LQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFIRNLVALDSGGSGGVVWRIRAN 1292
            ||||.||:||.|||||||||..||:||||||||||||::||:||||||.|:|||||||||||||:
Zfish   742 LQTLQGPHKHQSAVTCLQFNKNFVITSSDDGTVKLWDLRTGEFIRNLVTLESGGSGGVVWRIRAS 806

  Fly  1293 DTKLICAVGSRNGTEETKLMVLDFDVE 1319
            :|||:||||||||||||||:||||||:
Zfish   807 NTKLVCAVGSRNGTEETKLLVLDFDVD 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box_FBXW7	875..933	CDD:438905	48/57 (84%)
		WD40	<979..1267	CDD:441893	240/288 (83%)
		WD40 repeat	998..1033	CDD:293791	32/34 (94%)
		WD40 repeat	1039..1073	CDD:293791	25/33 (76%)
		WD40 repeat	1078..1112	CDD:293791	28/33 (85%)
		WD40 repeat	1119..1152	CDD:293791	23/32 (72%)
		WD40 repeat	1158..1192	CDD:293791	31/33 (94%)
		WD40 repeat	1200..1232	CDD:293791	27/31 (87%)
		WD40 repeat	1241..1263	CDD:293791	18/21 (86%)
fbxw7	XP_021329580.1	F-box_FBXW7	391..449	CDD:438905	48/57 (84%)
		WD40	503..778	CDD:238121	234/274 (85%)
		WD40 repeat	512..547	CDD:293791	32/34 (94%)
		WD40 repeat	553..587	CDD:293791	25/33 (76%)
		WD40 repeat	592..626	CDD:293791	28/33 (85%)
		WD40 repeat	633..666	CDD:293791	23/32 (72%)
		WD40 repeat	672..706	CDD:293791	31/33 (94%)
		WD40 repeat	714..746	CDD:293791	27/31 (87%)
		WD40 repeat	755..777	CDD:293791	18/21 (86%)